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US12

Gene
US12
Protein
Uncharacterized protein HVLF6
Organism
Human cytomegalovirus (strain AD169)
Length
281 amino acids
Similarity
Belongs to the cytomegalovirus US12 family.
Mass
32.469 kDa
Sequence
MVQIQFHQGEPLGHKKEKPPPVSPPSPPPIRRVTVITKDEDTLRSVQHFLWMVRLYGTVVFQTSATIATTILFMLIPWRVTAPYLRDTLPFWSTLLPCALRCHAYWLERRRRPGTLMLVMVYTTLTTISVSTIGLCFDRTVVIQAYVLSSMLCVWCTGLAWLMAWNMQRRLAILCLLSFMLPILWLFIAVQSWEPYQRIILALTVSFIYGLKIVLIRDTLTVLYRSPSNCYTDGDLLRTAMLLYMDQVIMFLLVVVPLTAPIWYPNYAGALGRTAHWLFHK

Gene
US12
Protein
Uncharacterized protein US12
Organism
Human cytomegalovirus (strain Merlin)
Length
281 amino acids
Similarity
Belongs to the cytomegalovirus US12 family.
Mass
32.471 kDa
Sequence
MVQIQFHQGEPLGHKKEKPPPVSPPSPPPIRRVTVITKDEDTLRSVQHFLWMVRLYGTVVFQTSATIATTILFMLIPWRVTTPYLRDTLPFWSTLLPCALRCHAYWLERQRRPGTLMLVMVYTTLTTISVSTIGLCFDRTVVIQAYVLSSMLCVWCTGLAWLMAWNMQRRLAILCLLSFMLPILWLFIAVQSWEPYQRIILALTVSFIYGLKIVLIRDTLTVLYRSPSNCYTDGDLLRTAMLLYMDQVIMFLLVVVPLTAPIWYPNYAGALGRTAHWLFHK

Gene
US12
Protein
ICP47 protein
Organism
Human herpesvirus 1 (strain 17)
Length
88 amino acids
Function
Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Similarity
Belongs to the herpesviridae US12 family.
Mass
9.793 kDa
Sequence
MSWALEMADTFLDTMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLRSPGLLPEIAPNASLGVAHRRTGGTVTDSPRNPVTR

Gene
US12
Protein
ICP47 protein
Organism
Human herpesvirus 2 (strain HG52)
Length
86 amino acids
Function
Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Similarity
Belongs to the herpesviridae US12 family.
Mass
9.785 kDa
Sequence
MSWALKTTDMFLDSSRCTHRTYGDVCAEIHKREREDREAARTAVTDPELPLLCPPDVRSDPASRNPTQQTRGCARSNERQDRVLAP

Gene
US12
Protein
ICP47 protein
Organism
Cercopithecine herpesvirus 1 (strain E2490)
Length
81 amino acids
Function
Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Similarity
Belongs to the herpesviridae US12 family.
Mass
8.946 kDa
Sequence
MSSRYLAAVDDYLHHPSPRYQAHVDLRRELRAYADEERREAARAIAHPERPLLPPPATQAAPPQPSTREAAHPSAPTAASS

Gene
US12
Protein
ICP47 protein
Organism
Herpes simplex virus type 2 (strain SA8)
Length
78 amino acids
Function
Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Similarity
Belongs to the herpesviridae US12 family.
Mass
8.572 kDa
Sequence
MSSLYLATVDAFLRNPHTRHRTCADLRRELDAYADEERREAAKAIAHPDRPLLAPPSAPPNHSHLAARETAPPPAATP

Gene
US12
Protein
ICP47 protein
Organism
Cercopithecine herpesvirus 16
Length
78 amino acids
Function
Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Similarity
Belongs to the herpesviridae US12 family.
Mass
8.567 kDa
Sequence
MSSLYLAEVDAFLQSPRTRHRTCADLRRELDAYADEERREAAKAIAHPDRPLLAPPSAPPDRSRPAPRGTAHPPAASP