URA1

Gene

ura1

Protein

Protein ura1

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843)

Length

2244 amino acids

Function

This protein is a fusion protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase).

Similarity

In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

Mass

248.309 kDa

Sequence

MSGLLPSLSSSFPLVQSEALGMPRTHGPKPSENDPKEPTCSPSPAFYSVNGEMKDYKLMALELEDKSVLQGYSFGADHSVSGELVFQTGMVGYPESLTDPSYRGQILVFTFPTVGNYGVPDRRILDEISGLPKYFESNQIHVAAIIISSYSQNYSHFLAHSSLGEWLKEQGIPGIFGIDTRALTKKIRDQGSMLGRLLIQKDESPINPSSITGLGKDWSTAFEDIPWKNPNTENLTSQVSIKEPKLYEPHPTTAIKKADGKIIRILVIDVGMKYNQIRCFLNRGVELLVVPWDYDFTKETYDGLFISNGPGDPSLMDLVVDRVKRVLESKTVPVFGICFGHQIMARAAGASTTKMKFGNRGHNIPCTCMISGRCYITSQNHGYAVDASSLSNGWKELFVNANDGSNEGIYNTEYPFFSVQFHPESTPGPRDTEFLFDVFIDVVKRSADAKSLQPFKLPGGTIEENRSRHPLVDAKRVLILGSGGLSIGQAGEFDYSGSQAIKALREEGIYTILINPNIATIQTSKGLADKVYFLPVNADFVRKVIKQERPDSIYVTFGGQTALNVGIELKDEFEQLGVKVLGTPIDTIITTEDRELFARAMDEINEKCAKSASASSIEEAIKVSKDISFPVIVRAAYALGGLGSGFADNEAELIDLCTLAFATSPQVLIERSMKGWKEIEYEVVRDAFDNCITVCNMENFDPLGIHTGDSIVVAPSQTLTDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPFTKEYCIIEVNARLSRSSALASKATGYPLAFTAAKLGLNIPLNEVKNSVTKVTCACFEPSLDYVVVKIPRWDLKKFTRVSTQLSSAMKSVGEVMSIGRTFEEAIQKAIRAIDYSNTGFNVKDALMSIDTELQTPSDQRLFAIANAMASGYSVDRIWELTRIDKWFLEKLMGLIRTSQLISKHDISSLPISLLKTAKQLGFADVQIAAFMNSTELAVRRIRTEAGIRPFVKQIDTVAAEFPAFTNYLYTTYNAVEHDIHFNDKGVMVLGSGVYRIGSSVEFDWCAVRAVRTLRDRGVKTIMVNYNPETVSTDYDEADRLYFENIGLETVLDIYEQESSSGIIIAMGGQTANNIALPLHRENVKILGTSPEMIDGAENRFKFSRMLDDIGVDQPKWKELTSFDEADKFCDTVGYPVLVRPSYVLSGAAMNTVYSQSDLHSYLQQAVAINKDHPVVISKYIENAKEIELDAVAREGKMVMHVISEHVENAGVHSGDATLVLPPQDLAPTTIERIVDAAAKIGEALNITGPYNIQFIAKDNEIKVIECNVRASRSFPFVSKVIGVDMISMATDVIMGNPIQPYPDVDLPRDYVAVKVPQFSFSRLSGADPVLGVEMASTGEVACFGHNKFEAYLKAMISTGFRLPKKNILISIGSYKEKAELLPYVKKLYENNYNIFATAGTSDYFMESGVPCKYLADLPAEEANNEYSLSAHLANNMIDMYINLPSNNRYRRPANYISSGYKSRRLAIDYSVPLVTNVKCAKLMIEAICRNLDFSLSTVDFQSSFQTANLPGLINISAFLPEFTSEAVSDYTKECIASGFTMARFLPFSTSSTLADKDSLSAVKKLALDHAHCDYNFSVIASSTNEVTISELTSESGCLFFHFEKDDSGIDHVTAVASHFNVWPDTQTVMTDAKSTTLASLLLLASLHNRRIHITNVSSKDDLNLIVLAKQRSLPVTFDVSVYSLFLNQNDYPGATFLPTADDQVEIWNKLSYIDCFSIGSIPSRLAKFVGNTAFTGFGVREAIPLLLTAVNEGRLTLKDVVDRFYSNPKAIFRLHDQDDSGVQLEVDRSVSWSSKDWTPFNGKKLYGSIQSVQFDGHDVFFDGELNFEHTYGRDYSSASLADKSKATRKVSALMSPGLPHAAPSLAEAFGQAPENKAHPDISLNMTPNFKPSHELVQLINSSPFYRKHIISVHQVTRSDLHVLFAIAHQMRIIVERQGVIDLCYGKLLCTMFFEPSTRTSSSFDAAMQRLGGKVVAVTASASSVNKGESLADTIRTLGCYGDAIVLRHPSIESARIAANFSPVPIINGGNGSKEHPTQAFLDLYTIREELGSVNGLTITFIGDLKYGRTVHSLARLLAFWHVELHLVSPEQLALPDDVKDDIRANGLNFIEHRELTKEVVAQSDVLYCTRVQKERFASVDEYEKLKDSFIVDNSVLASAKSHCIVMHPLPRNREISEEVDFDQRRAAYFRQMRYGLYIRMALLACVMGATEVAN

Gene

URA1

Protein

Dihydroorotate dehydrogenase (quinone), mitochondrial

Organism

Agrocybe aegerita

Length

328 amino acids

Function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Similarity

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Mass

35.085 kDa

Sequence

MSGLFETLGRRALFAFDAEQAHGLSIAGLKTGLVTGSAPNDLALSVKVAGLQFPNPLGMAAGYDKNAEVPDALLKLGFGFTEIGTITPRPQSGNPRPRIFRLVDDKAVINRLGFNNEGHDAAFKRLSQRAGKSGIVGVNIGANKDAEDRIADYVAGIRRFYQLARYFTVNISSPNTPGLRNLQARDSLRELLSRVLEARNEEGKMCTLKRPVFLKIAPDLANEELDDIAAEATEQKLDGIIISNTTLSRAGLKSAGGRDETGGLSGAPLFDRSTIVLARMRERVGPDMPLIGVGGVDSAETALTKVKAGARSRPALYGPDLSRPEPAY

Protein

Dihydroorotate dehydrogenase (quinone), mitochondrial: URA1

Gene

URA1

Protein

Dihydroorotate dehydrogenase (fumarate)

Organism

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)

Length

315 amino acids

Function

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.

Similarity

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.

Mass

34.989 kDa

Sequence

MKPSLQVEFCGHIYENPLMNASGVCCMTTNELDDMARSSSGAFITKSATSMERDGNPEPRYVSVPLGSINSMGLPNKGIDYYLDYVLDRQDRFPSENPPFMSVAGMSIDENIKLLHRIQDSNFRGITELNLSCPNVPGKPQVAYDFELTDQILSSVFEFFTKPLGVKLPPYFDFAHFDAMACILNKYPIAYVNCINSVGNGLYIDVEKESVVIKPKDGFGGIGGEYIKPTALANVRAFYNRLNGRIRIIGTGGIKTGQDAFEHLLCGATMLQIGTELQNEGTEIFERINAELLQILEQKGYQSIEDFRGKLRSIS

Protein

Dihydroorotate dehydrogenase (fumarate): URA1

Gene

URA1

Protein

Dihydroorotate dehydrogenase (fumarate)

Organism

Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630)

Length

314 amino acids

Function

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.

Similarity

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.

Mass

34.862 kDa

Sequence

MPASLTTKFLNQTYENPLMNASGVHCMTTKELDELAASRAGAFITKSSTTLERAGNPEPRYVSVPLGSINSMGLPNQGIDYYLEYVLERQRTHPNEPAIFFSVAGMSIDENINMLRKIQDSEFHGITELNLSCPNVPGKPQVAYDFDLTKEILDKVFQFFKKPLGIKLPPYFDFAHFDIMAGILNQYPLAYVNSINSVGNGLYIDVDKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLNPSIKIVGTGGIRTGKDVFEHLLCGASMVQIGTELVKEGVPIFERLERELKEVMDKKGYTTIEEFRGKLNSL

Protein

Dihydroorotate dehydrogenase (fumarate): URA1

Gene

URA1

Protein

Dihydroorotate dehydrogenase (fumarate)

Organism

Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / CCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651)

Length

314 amino acids

Function

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.

Similarity

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.

Mass

34.855 kDa

Sequence

MSASLAINFLNHTYENPFMNASGVHCMSTKELDELKDSRAGAFITKSSTTSKREGNPEPRYFSVPLGSINSMGLPNEGFDYYLKYALEYQKNGSTSTPLFFSVAGMSVEENLKMLQKIQDSDFNGITELNLSCPNVPGKPQVAYDFELTKEILTKVFEFFKKPLGVKLPPYFDFAHFDIMAGILNQLPLSYVNCINSIGNGLYINVETESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLNPTIKIIGTGGIKTGQDAFEHLLCGATMLQVGTELYKEGVSIFDRLERELKELMDKKGYTSIEQFRGKLNSL

Protein

Dihydroorotate dehydrogenase (fumarate): URA1

Gene

URA1

Protein

Dihydroorotate dehydrogenase (fumarate)

Organism

Saccharomyces bayanus

Length

314 amino acids

Function

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.

Similarity

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.

Mass

34.702 kDa

Sequence

MTASLTTKFLDNTYENPFMNASGVHCMTTPELDELANSKAGAFITKSATTLEREGNPKPRYISVPLGSINSMGLPNEGVDYYLSHVLNRQKKYPDAPAIFFSVAGMSIDENLGLLKKIQESEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFNKPLGIKLPPYFDFAHFDIMAKILNEFPLAYVNSINSVGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKIIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVQIFERIERELKDIMEAKGYTSIDEFRGKLNSL

Protein

Dihydroorotate dehydrogenase (fumarate): URA1

Gene

URA1

Protein

Dihydroorotate dehydrogenase (fumarate)

Organism

Saccharomyces mikatae

Length

314 amino acids

Function

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.

Similarity

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.

Mass

34.812 kDa

Sequence

MTASLTTKFLNNTYENPFMNASGVHCMTTEELDELADSKAGAFITKSATTLEREGNPKPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKKYPDAPAIFFSVAGMSIDENLNLLKKIQDSEFNGITELNLSCPNVPGKPQVAYDFELTKETLEKVFVFFKKPLGIKLPPYFDFAHFDIIAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPDIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLNSL

Protein

Dihydroorotate dehydrogenase (fumarate): URA1

Gene

URA1

Protein

Dihydroorotate dehydrogenase (fumarate)

Organism

Saccharomyces paradoxus

Length

314 amino acids

Function

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.

Similarity

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.

Mass

34.82 kDa

Sequence

MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPKPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKEHPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLDRVFAFFKKPLGIKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGMLNSI

Protein

Dihydroorotate dehydrogenase (fumarate): URA1

Gene

URA1

Protein

Dihydroorotate dehydrogenase (fumarate)

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Length

314 amino acids

Function

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro. Does not use oxaloacetate or NAD or NADP as electron acceptors.

Similarity

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.

Mass

34.801 kDa

Sequence

MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLNSI

Protein

Dihydroorotate dehydrogenase (fumarate): URA1

Gene

URA1

Protein

Orotidine 5'-phosphate decarboxylase

Organism

Schizophyllum commune

Length

278 amino acids

Similarity

Belongs to the OMP decarboxylase family.

Mass

29.979 kDa

Sequence

MTAAHKLTYGQRAARFTNPAAKALLETMERKKSNLSVSVDVVKSADLLAIVDTVGPYICLIKTHVDVVEDFDSSLVTKLQALAEKHDFLIFEDRKFADIGNTVALQYSSGVHKIASWSHITNAHPVPGPSIISGLASVGQPLGRGLLLLAEMSTKGSLATGAYTEAAVQMARENRGFVIGFIAQRRMDGIGAPPGVNVEDEDFLVLTPGVGLDVKGDGMGQQYRTPKQVVQEDGCDVIIVGRGIYGKDPSKVEEIRRQAERYQAAGWAAYIERVNALV

Protein

Orotidine 5'-phosphate decarboxylase: URA1