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UL69

Gene
UL69
Protein
mRNA export factor ICP27 homolog
Organism
Murid herpesvirus 1 (strain Smith)
Length
841 amino acids
Function
Immediate early (EI) protein that plays many roles during productive infection including regulation of viral gene expression and nuclear export of intronless viral RNAs.
Similarity
Belongs to the HHV-1 ICP27 protein family.
Mass
92.707 kDa
Sequence
MLRTGVKRRLGPFAGYDEDDAATGGVSRRSKYSQQQSQHYYYGHNQSSYRDSGASHPNWKRNAHLMPPPLSSPSSPPPQYDKNIAALTHLNKKLDCLGPDDLECLKAMIRIREARAQGRRPEPSSAPSILESSLVSSNNSNNNTTLSLGGGGGGDYHRQTSPDIRDYTTGSLGLCMFPMDLPDPIKLLENRYTDNDRHAPAVVTHDELINTNYLLLFRKHFDALPPEELRVLVQDRTFAINNAPSLDVVAAMADENLTYVKFHRVHNLPVNPKDLYMSTLGLIKYATFNKLNLGELSCLLDSPGGGGSDREYHILRQIANKPASPCRKGGSSAAAAASFDVLRRPPLSFKHPLQQALALIASFARIVGVIRRRSLRHSGPFFIRDFDDTGATDSYRCGMISELIFDYLPGHRCQNEICRVKLKKLLQPYTSTLFFCAYNNTRKHPNGLPARRSPERRAPDATPNIPRLAYRRSATTSPEVEPAPPSRMTSSSPRVDSRGGGGDRRGDSSSTSSNHHRHHTRRARTRSTHDSSSSGSRRRSSATDGRRSRRGSRRGEAQRESNGHHSSKSPSTVSSTTVHGQNGARGDSAPSRKSQQSQQQPETTSKESSKTAAMPPPPSPCSPSPASRERRPSKSPSSSPRPHDPPSGEPADAEKELATAGDEDEGVRSPGECSVATRRGSSADESSDSSSSSSDSSSSSDEEESDVEDCRELDLQSKRLEEALEERCERDFEADDEEFAEPIEEDDLHCSLDMEEDIEDEPLDPETESVWTASVTPLAAPPSIRILDHEPGDAEEEEESDTDFYDETDQPLNKRIHLRSATPTDDVIMECDLSYSEMDSD

Gene
UL69
Protein
mRNA export factor ICP27 homolog
Organism
Human cytomegalovirus (strain AD169)
Length
744 amino acids
Function
Immediate early (EI) protein that plays many roles during productive infection including regulation of host cell cycle progression, regulation of viral gene expression or nuclear export of intronless viral RNAs. Acts as a transcriptional transactivator via interaction with the cellular transcription elongation factor SUPT6H (PubMed:22171252). In addition, acts as a post-transcriptional transactivator that mediates the nuclear export of unspliced mRNAs via interaction with DDX39B, a component of the cellular mRNA export machinery (PubMed:16478985, PubMed:26178996).
Similarity
Belongs to the HHV-1 ICP27 protein family.
Mass
82.678 kDa
Sequence
MELHSRGRHDAPSLSSLSERERRARRARRFCLDYEPVPRKFRRERSPTSPSTRNGAAASEHHLAEDTVGAASHHHRPCVPARRPRYSKDDDTEGDPDHYPPPLPPSSRHALGGTGGHIIMGTAGFRGGHRASSSFKRRVAASASVPLNPHYGKSYDNDDGEPHHHGGDSTHLRRRVPSCPTTFGSSHPSSANNHHGSSAGPQQQQMLALIDDELDAMDEDELQQLSRLIEKKKRARLQRGAASSGTSPSSTSPVYDLQRYTAESLRLAPYPADLKVPTAFPQDHQPRGRILLSHDELMHTDYLLHIRQQFDWLEEPLLRKLVVEKIFAVYNAPNLHTLLAIIDETLSYMKYHHLHGLPVNPHDPYLETVGGMRQLLFNKLNNLDLGCILDHQDGWGDHCSTLKRLVKKPGQMSAWLRDDVCDLQKRPPETFSQPMHRAMAYVCSFSRVAVSLRRRALQVTGTPQFFDQFDTNNAMGTYRCGAVSDLILGALQCHECQNEMCELRIQRALAPYRFMIAYCPFDEQSLLDLTVFAGTTTTTASNHATAGGQQRGGDQIHPTDEQYANMESRTDPATLTAYDKKDREGSHRHPSPMIAAAPPAQPPSQPQQHYSEGELEEDEDSDDASSQDLVRATDRHGDTVVYKTTAVPPSPPAPLAGVRSHRGELNLMTPSPSHGGSPPQVPHKQPIIPVQSANGNHSTTATQQQQPPPPPPPPPVPQEDDSVVMRCQTPDYEDMLCYSDDMDD

Gene
UL69
Protein
mRNA export factor ICP27 homolog
Organism
Human cytomegalovirus (strain Merlin)
Length
742 amino acids
Function
Immediate early (EI) protein that plays many roles during productive infection including regulation of host cell cycle progression, regulation of viral gene expression or nuclear export of intronless viral RNAs. Acts as a transcriptional transactivator via interaction with the cellular transcription elongation factor SUPT6H and as a nuclear RNA export factor via interaction with UAP56, a component of the cellular mRNA export machinery (By similarity).
Similarity
Belongs to the HHV-1 ICP27 protein family.
Mass
82.397 kDa
Sequence
MELHSRGRHDAPSLSSLSERERRARRARRFCLDYEPVPRKFRRERSPTSPSTRNGAAASEYHLAEDTVGAASHHHRPCVPARRPRYSKDDDTEGDPDHYPPPLPPSSRHALGGTGGHIIMGTAGFRGGHRASSSFKRRVAASASVPLNPHYGKSYDNDDGEPHHHGGDSTHLRRRVPSCPTTFGSSHPSSANNHHGSSAGPQQQQMLALIDDELDAMDEDELQQLSRLIEKKKRARLQRGAASSGTSPSSTSPVYDLQRYTAESLRLAPYPADLKVPTAFPQDHQPRGRILLSHDELMHTDYLLHIRQQFDWLEEPLLRKLVVEKIFAVYNAPNLHTLLAIIDETLSYMKYHHLHGLPVNPHDPYLETVGGMRQLLFNKLNNLDLGCILDHQDGWGDHCSTLKRLVKKPGQMSAWLRDDVCDLQKRPPETFSQPMHRAMAYVCSFSRVAVSLRRRALQVTGTPQFFDQFDTNNAMGTYRCGAVSDLILGALQCHECQNEMCELRIQRALAPYRFMIAYCPFDEQSLLDLTVFAGTTTTTASNHATAGGQQRGGDQIHPTDEQCASMESRTDPATLTAYDKKDREGSHRHPSPMIAAAAPPAQPPSQPQQHYSEGELEEDEDSDDASSQDLVRATDRHGDTVVYKTTAVPPSPPAPLAGVRSHRGELNLMTPSPSHGGSPPQVPHKQPIIPVQSANGNHSTTATQQQQPPPPPPVPQEDDSVVMRCQTPDYEDMLCYSDDMDD