UL46

Tegument protein UL46

722 amino acids

Plays a role in the activation of the host PI3K/AKT pathway to promote cell survival. Interacts with and activates host LCK and thereby recruits downstream partners SHC1, GRB2 and PI3KR1 in order to activate the PI3K pathway by phosphorylating host AKT on its activating residues. This mechanism is inhibited by the viral protein US3 that instead promotes incorporation of UL46 into virions.

Belongs to the herpesviridae HHV-1 VP11/12 protein family.

77.709 kDa

MQRRARGASSLRLARCLTPANLIRGANAGVPERRIFAGCLLPTPEGLLSAAVGVLRQRADDLQPAFLTGADRSVRLAARHHNTVPESLIVDGLASDPHYDYIRHYASAAKQALGEVELSGGQLSRAILAQYWKYLQTVVPSGLDIPDDPAGDCDPSLHVLLRPTLLPKLLVRAPFKSGAAAAKYAAAVAGLRDAAHRLQQYMFFMRPADPSRPSTDTALRLSELLAYVSVLYHWASWMLWTADKYVCRRLGPADRRFVALSGSLEAPAETFARHLDRGPSGTTGSMQCMALRAAVSDVLGHLTRLAHLWETGKRSGGTYGIVDAIVSTVEVLSIVHHHAQYIINATLTGYVVWASDSLNNEYLTAAVDSQERFCRTAAPLFPTMTAPSWARMELSIKSWFGAALAPDLLRSGTPSPHYESILRLAASGPPGGRGAVGGSCRDKIQRTRRDNAPPPLPRARPHSTPAAPRRCRRHREDLPEPPHVDAADRGPEPCAGRPATYYTHMAGAPPRLPPRNPAPPEQRPAAAARPLAAQREAAGVYDAVRTWGPDAEAEPDQMENTYLLPDDDAAMPAGVGLGATPAADTTAAAAWPAESHAPRAPSEDADSIYESVGEDGGRVYEEIPWVRVYENICPRRRLAGGAALPGDAPDSPYIEAENPLYDWGGSALFSPRRATRAPDPGLSLSPMPARPRTNALANDGPTNVAALSALLTKLKRGRHQSH

UL46

Tegument protein UL46

718 amino acids

Plays a role in the activation of the host PI3K/AKT pathway to promote cell survival. Interacts with and activates host LCK and thereby recruits downstream partners SHC1, GRB2 and PI3KR1 in order to activate the PI3K pathway by phosphorylating host AKT on its activating residues. This mechanism is inhibited by the viral protein US3 that instead promotes incorporation of UL46 into virions. Plays a role in the inhibition of TMEM173/STING-mediated type I interferon production (PubMed:28592536). Interacts with host DOK2 and induces its degradation. This immune evasion mechanism to inactivate T-cells may play an important role during pathogenesis (PubMed:28841444).

Belongs to the herpesviridae HHV-1 VP11/12 protein family.

78.241 kDa

MQRRTRGASSLRLARCLTPANLIRGDNAGVPERRIFGGCLLPTPEGLLSAAVGALRQRSDDAQPAFLTCTDRSVRLAARQHNTVPESLIVDGLASDPHYEYIRHYASAATQALGEVELPGGQLSRAILTQYWKYLQTVVPSGLDVPEDPVGDCDPSLHVLLRPTLAPKLLARTPFKSGAVAAKYAATVAGLRDALHRIQQYMFFMRPADPSRPSTDTALRLNELLAYVSVLYRWASWMLWTTDKHVCHRLSPSNRRFLPLGGSPEAPAETFARHLDRGPSGTTGSMQCMALRAAVSDVLGHLTRLANLWQTGKRSGGTYGTVDTVVSTVEVLSIVHHHAQYIINATLTGYGVWATDSLNNEYLRAAVDSQERFCRTTAPLFPTMTAPSWARMELSIKAWFGAALAADLLRNGAPSLHYESILRLVASRRTTWSAGPPPDDMASGPGGHRAGGGTCREKIQRARRDNEPPPLPRPRLHSTPASTRRFRRRRADGAGPPLPDANDPVAEPPAAATQPATYYTHMGEVPPRLPARNVAGPDRRPPAATCPLLVRRASLGSLDRPRVWGPAPEGEPDQMEATYLTADDDDDDARRKATHAASARERHAPYEDDESIYETVSEDGGRVYEEIPWMRVYENVCVNTANAAPASPYIEAENPLYDWGGSALFSPPGRTGPPPPPLSPSPVLARHRANALTNDGPTNVAALSALLTKLKREGRRSR

UL46

Tegument protein UL46

715 amino acids

Plays a role in the activation of the host PI3K/AKT pathway to promote cell survival. Interacts with and activates host LCK and thereby recruits downstream partners SHC1, GRB2 and PI3KR1 in order to activate the PI3K pathway by phosphorylating host AKT on its activating residues. This mechanism is inhibited by the viral protein US3 that instead promotes incorporation of UL46 into virions.

Belongs to the herpesviridae HHV-1 VP11/12 protein family.

77.357 kDa

MQRRTRGASSLRLARCLTPANLIRGDNAGVPERRIFGGCLLPTPEGLLSAAVGALRQRSDDAQPAFLTCTDRSVRLAARQHNTVPESLIVDGLASDPHYEYIRHYASAATQALGEVELTGGQLSRAILTQYWKYLQTVVPSGLDVPEDPVGDCDPSLHVLLRPTLAPKLLARTPFKSGAAAAKYAATVAGLRDALHRIQQYMFFMRPADPSRPSTDTALRLNELLAYVSVLYRWASWMLWTTDKHVCHRLSPSNRRFLPLGGSPEAPAETFARHLDRGPSGTTGSMQCMALRAAVSDVLGHLTRLANLWQTGKRSGGTYGTVDTVVSTVEVLSIVHHHAQYIINATLTGYGVWATDSLNNEYLRAAVDSQERFCRTTAPLFPTMTAPSWARMELSIKAWFGAALAADLLRSGAPSLHYESILRLVASRRTTWSAGPPPDDMARGPGGHRAGGGTVGKRFSGPARQRAPAPPPTSPTLDPRGHPAVPEAPRGRPAPPLPDADDPVAEPPGCAAQPATYYTHMGEVPPRLPARNVAGPDRRPPAATCPLLVRRASLGSLDRPRGWGPAPEGEPDQMEATYLTADDDDDARRKATHAASARERHAPYEDDESIYETVSEDGGRVYEEIPWMRVYENVCANTANAAPASPYIEAENPLYDWGGSALFSPPPRPPPPPPLSPSPVLARHRANALTNDGPTNVAALSALLTKLKREGRRSR

UL46

Alpha trans-inducing factor

607 amino acids

Abundant tegument protein. Trans-activates the immediate early genes (By similarity).

Belongs to the herpesviridae HHV-1 VP11/12 protein family.

67.233 kDa

MSTKSSPARGTVYIPGHAMTLRSVELKKIPIKVLKTVFENAQKISPVWSLEQASLNSLAATAETMLPGPILGPSRAEHFNGPDPTIPDKMVVRMVEGDHKMLFRATLDDTYHILVTRIRVREKFVQRLARAMYTRRASMLMDVELPFKDKMEGVYAAADLEAICKMHYWVFPHTVPAPNMKSPDDKAYLTSVAQFARSTKFIESYMYYMRPHDPEVNSTDTGNRVAAMLIYIHGMQCKLASLFDALDAAILRSKFNAGSRGHSLSGIYGFTRNGKGTMMAAKSSGNVVEQIRRTCPFGSDAMVECLISALDRMTYLVARWELMSVDKRDDAKAAIAAGMGLAWLLNGHLSYLTNMIMTVYVLWLPEHYLNPRLILTISSRVLLGQLLCTSHTTFRENATCPKMLLAQNAVEWKKQERGTAAWLDYVCARAWLRASRENRKPANITAMNNTLEEISAHVLKILEEAPQPAASAPSSLCATNYCPDSPPSRPPPPPPVQKRAKDPGRFSRIMAGDDRRASVQSREDGSGYMTCEHTASTSTKLRGRVLSAPLIRHRRKSAEGLQGAAKLRGGSLRLPDNGGRAALPSEPPPSSESTDTSPEARPETDHK