Organism
Human cytomegalovirus (strain Merlin)
Function
Remodels the host actin cytoskeleton in order to impair immune recognition of infected cells. Mechanistically, interacts with members of the host WAVE2 complex and redirects the complex to the plasma membrane. In turn, the efficiency of immune synapse formation is greatly reduced.
Similarity
Belongs to the HCMV UL135 family.
Sequence
MVWLWLGVGLLGGTGLASLVLAISLFTQRRGRKRSDETSSRGRLPGAASDKRGACACCYRIPKEDVVEPLDLELGLMRVATHPPTPQVPRCTSLYIGEDGLPIDKPEFPPARFEIPDVSTPGTPTSIGRSPSHCSSSSSLSSSASVDTVLHQPPPSWKPPPPPGRKKRPPTPPVRAPTTRLSSHRPPTPIPAPRKNLSTPPTKKTPPPTKPKPVGWTPPVTPRPFPKTPTPQKPPRNPRLPRTVGLENLSKVGLSCPCPRPRTPTEPTTLPIVSVSELAPPPRWSDIEELLEKAVQSVMKDAESMQMT