About Products Protein Database Contact

UL135

Gene
UL135
Protein
Protein UL135
Organism
Human cytomegalovirus (strain Merlin)
Length
308 amino acids
Function
Remodels the host actin cytoskeleton in order to impair immune recognition of infected cells. Mechanistically, interacts with members of the host WAVE2 complex and redirects the complex to the plasma membrane. In turn, the efficiency of immune synapse formation is greatly reduced.
Similarity
Belongs to the HCMV UL135 family.
Mass
33.281 kDa
Sequence
MVWLWLGVGLLGGTGLASLVLAISLFTQRRGRKRSDETSSRGRLPGAASDKRGACACCYRIPKEDVVEPLDLELGLMRVATHPPTPQVPRCTSLYIGEDGLPIDKPEFPPARFEIPDVSTPGTPTSIGRSPSHCSSSSSLSSSASVDTVLHQPPPSWKPPPPPGRKKRPPTPPVRAPTTRLSSHRPPTPIPAPRKNLSTPPTKKTPPPTKPKPVGWTPPVTPRPFPKTPTPQKPPRNPRLPRTVGLENLSKVGLSCPCPRPRTPTEPTTLPIVSVSELAPPPRWSDIEELLEKAVQSVMKDAESMQMT

Gene
UL135
Protein
Protein UL135
Organism
Human cytomegalovirus (strain Towne)
Length
308 amino acids
Function
Remodels the host actin cytoskeleton in order to impair immune recognition of infected cells. Mechanistically, interacts with members of the host WAVE2 complex and redirects the complex to the plasma membrane. In turn, the efficiency of immune synapse formation is greatly reduced.
Similarity
Belongs to the HCMV UL135 family.
Mass
33.41 kDa
Sequence
MVWIWLGVGLLGGTGLASLVLAISLFTQRRGRKRSDETSSRGRLPAAASDKRGACACCYRNPKEDVVEPLDLELGLMRVATHPPTPQVPRCTSLYIGEDGLPIDKPEFPPARFEIPDVSTPGTPTSIDRSPSHCSSLSSLSSSTSVDTVLHQPPPSWKPPPPPGRKKRPPTPPVRAPTTRLSSHRPPTPIPAPRKNLSTPPTKKTPPPTKPKPVGWTPPVTPRPFPKTPTPQKPPRNPRLPRTVGLENLSKVGLSCPCPRPRTPTEPTTLPIVSVSELAPPPRWSDIEELLEQAVQSVMKDAESMQMT