UL13

Serine/threonine-protein kinase UL13

518 amino acids

Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and regulation of viral and cellular gene expression. Regulates the nuclear localization of viral envelopment factors UL34 and UL31, by phosphorylating the US3 kinase, indicating a role in nuclear egress. Disrupts host nuclear lamins, including LMNA and LMNB1. Phosphorylates the viral Fc receptor composed of glycoproteins E (gE) and I (gI). Phosphorylation of glycoprotein E (gE) by UL13 alters its subcellular localization, from the host early endosome to the plasma membrane. Participates in the transcriptional regulation of cellular and viral mRNAs mainly by phosphorylating the viral transcriptional regulator ICP22. Additional substrates have been identified, including UL41, UL49 or host EF1D.

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

57.197 kDa

MDESRRQRPAGHVAANLSPQGARQRSFKDWLASYVHSNPHGASGRPSGPSLQDAAVSRSSHGSRHRSGLRERLRAGLSRWRMSRSSHRRASPETPGTAAKLNRPPLRRSQAALTAPPSSPSHILTLTRIRKLCSPVFAINPALHYTTLEIPGARSFGGSGGYGDVQLIREHKLAVKTIKEKEWFAVELIATLLVGECVLRAGRTHNIRGFIAPLGFSLQQRQIVFPAYDMDLGKYIGQLASLRTTNPSVSTALHQCFTELARAVVFLNTTCGISHLDIKCANILVMLRSDAVSLRRAVLADFSLVTLNSNSTIARGQFCLQEPDLKSPRMFGMPTALTTANFHTLVGHGYNQPPELLVKYLNNERAEFTNHRLKHDVGLAVDLYALGQTLLELVVSVYVAPSLGVPVTRFPGYQYFNNQLSPDFALALLAYRCVLHPALFVNSAETNTHGLAYDVPEGIRRHLRNPKIRRAFTDRCINYQHTHKAILSSVALPPELKPLLVLVSRLCHTNPCARHALS

UL13

Serine/threonine-protein kinase UL13

518 amino acids

Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and regulation of viral and cellular gene expression. Regulates the nuclear localization of viral envelopment factors UL34 and UL31, by phosphorylating the US3 kinase, indicating a role in nuclear egress. Disrupts host nuclear lamins, including LMNA and LMNB1. Phosphorylates the viral Fc receptor composed of glycoproteins E (gE) and I (gI). Phosphorylation of glycoprotein E (gE) by UL13 alters its subcellular localization, from the host early endosome to the plasma membrane. Participates in the transcriptional regulation of cellular and viral mRNAs mainly by phosphorylating the viral transcriptional regulator ICP22. Additional substrates have been identified, including UL41, UL49 or host EF1D (By similarity).

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

57 kDa

MDESGRQRPASHVAADISPQGAHRRSFKAWLASYIHSLSRRASGRPSGPSPRDGAVSGARPGSRRRSSFRERLRAGLSRWRVSRSSRRRSSPEAPGPAAKLRRPPLRRSETAMTSPPSPPSHILSLARIHKLCIPVFAVNPALRYTTLEIPGARSFGGSGGYGEVQLIREHKLAVKTIREKEWFAVELVATLLVGECALRGGRTHDIRGFITPLGFSLQQRQIVFPAYDMDLGKYIGQLASLRATTPSVATALHHCFTDLARAVVFLNTRCGISHLDIKCANVLVMLRSDAVSLRPAVLADFSLVTLNSNSTISRGQFCLQEPDLESPRGFGMPAALTTANFHTLVGHGYNQPPELSVKYLNNERAEFNNRPLKHDVGLAVDLYALGQTLLELLVSVYVAPSLGVPVTRVPGYQYFNNQLSPDFAVALLAYRCVLHPALFVNSAETNTHGLAYDVPEGIRRHLRNPKIRRAFTEQCINYQRTHKAVLSSVSLPPELRPLLVLVSRLCHANPAARHSLS

UL13

Uncharacterized protein UL13

473 amino acids

Belongs to the HHV-5 UL13 protein family.

54.613 kDa

MLWAHCGRFLRYHLLPLLLCRLPFLLLFQRPQWAHGLDIVEEDEWLREIQGATYQLSIVRQAMQHAGFQVRAASVMTRRNAVDLDRPPLWSGSLPHLPVYDVRSPRPLRPPSSQHHAVSPELPSRDGIRWQYQELQYLVEEQRRRNQSRNAIPRPSFPPPDPPSQPAEDARDADAERTESPHSAESTVRHDASENAVRRRHERRRYNALTVRSRDSLLLTRIRFSNQRCFGRGRLRHPAGSGPNTGGPRPGGAGLRQLRQQLTVRWQLFRLRCHGWTQQVSSQIRTRWEESNVVSQTATRVRTWFVERTTFWRRTWVPRQNPAAEAQELAVIPPAPTVLRQNEEPRQQLTGEETRNSTHTQREEVEDVSREGAREGNDGSRASGNDERRNNAGRYDDDHEVQEPQVTYPAGQGELNRRSQEENEEGGPCESPPMTTNTLTVACPPREPPHRALFRLCLGLWVSSYLVRRPMTI

UL13

Uncharacterized protein UL13

473 amino acids

Belongs to the HHV-5 UL13 protein family.

54.427 kDa

MLWAHCGRFLRYHLLPLLLCRLPFLLFFQRPQWAHGLDIVEEDEWLREIQGATYQLSIVRQAMQHAGFQVRAASVMTRRNAVDLDRPPLWSGSLPHLPVYDVRSPRPLRPPSSQHHAVSPELPSRNGIRWQYQELQYLVEEQRRRNQSRNAIPRPSFPPPDPPSQPAEDARDADAERAESPHTAESTVSHDASDNAVRRRHERRRYNALTVRSRDSLLLTRIRFSNQRCFGRGRLRHPAGSGPNTGGPRPGGAGLRQLRQQLTVRWQLFRLRCHGWTQQVSSQIRTRWEESNVVSQTATRVRTWFVQRTTLWRRTWVPGQNPAAEAQELAIIPPAPTVLRQNEEPRQQLTGEETRNSTHTQREEVEDVSREGAREGNDGSRASGNDERRNNAGRYDDDHEVQEPQVTYPAGQGELNRRSQEENEEGGPCESPPMTTNTLTVACPPREPPHRALFRLCLGLWVSSYLVRRPMTI

UL13

Serine/threonine-protein kinase UL13

460 amino acids

Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and regulation of viral and cellular gene expression. Regulates the nuclear localization of viral envelopment factors UL34 and UL31 homologs, by phosphorylating the US3 kinase homolog, indicating a role in nuclear egress. Disrupts host nuclear lamins, including LMNA and LMNB1. Phosphorylates the viral Fc receptor composed of glycoproteins E (gE) and I (gI). Phosphorylation of glycoprotein E (gE) by UL13 homolog alters its subcellular localization, from the host early endosome to the plasma membrane. Participates in the transcriptional regulation of cellular and viral mRNAs mainly by phosphorylating the viral transcriptional regulator ICP22 homolog (By similarity).

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

50.687 kDa

MATRGRPGAKQVADHSVSDGGEQRRIPQKPPGPERCDVCSAVSAAGAAADLIDVAPLEEDLTKEPQQIVVTIMSNDPAKVCLKVDPALHYRNVELEPYRFLGRGGYGSVFYSRRANVAVKALTHGASFRWELAVSLIVSSAARRQELSDIAKHFLQIYAFSSVEKIIVMEYIRHDLRTYLDEHCKPVTQSALDALVREFRGLAKALAFFHIECGLAHLDVKQNNILVNCDPRTGDPVRMVLADFSLAAINGNSFLNKCCMVCPGRPGVTGVHIIDTEDAVNSLPSNNILLFRMSRRPPEFLLDYCNGVGPRCGEVMGAMTTFAMDVFALGSVVHEVLLLCLSRVLGRDPFPHMTCTDEPMDHKTILSLLAYRLALTDYLSQSWSSAGFVNPAGTREGISSALQWECMRDMFLASAEAWTRTVRRKMNGARSPSMFADILDLSILLCHFDPDVRRTVSALA

UL13

Serine/threonine-protein kinase UL13

398 amino acids

Multifunctional serine/threonine kinase that plays a role in several processes including egress of virus particles from the nucleus, modulation of the actin cytoskeleton and regulation of viral and cellular gene expression. Regulates the nuclear localization of viral envelopment factors UL34 and UL31, by phosphorylating the US3 kinase, indicating a role in nuclear egress. Disrupts host nuclear lamins, including LMNA and LMNB1. Phosphorylates the viral Fc receptor composed of glycoproteins E (gE) and I (gI). Phosphorylation of glycoprotein E (gE) by UL13 alters its subcellular localization, from the host early endosome to the plasma membrane. Participates in the transcriptional regulation of cellular and viral mRNAs mainly by phosphorylating the viral transcriptional regulator ICP22 (By similarity).

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

41.417 kDa

MAAGGGGGGVSRAALARPPIHRGTSAPGGAIAAAGGDGDGDEASRLLGRAQPREAPYLIPRPDGDLAVPDDLQYATLDLTGDPVAVGAGSYGSVLVYGSVAVKTLRAGFGHEAVMTLLAAEEARSAGVRGVVRLMGLSAPLRQLMFPAYEMDMDAYRRSLTARPGHVVHALGRVFTELGRALVFLNGRGLSHLDVKGGNIFVRTCGNMVVTAVIGDFSLMALNSRSALADPRFRLARRKALKITSLARSPPTGVLLGHARDRPTRVLMDFINGRPPPPGPLPYEVGLAIDLCALGHVLLDVALGLRPQRGQALTREYAVEVLARRCVLFAALLPPGSGPSAEALAGDILEEELAAGFREGVASSRPGNQPPRTVAPLLELVARFCGEDGGARFAELAA