UL12

Alkaline nuclease

626 amino acids

Isoform UL12.5: Degrades host mitochondrial DNA.

Belongs to the herpesviridae alkaline nuclease family.

67.508 kDa

MESTVGPACPPGRTVTKRPWALAEDTPRGPDSPPKRPRPNSLPLTTTFRPLPPPPQTTSAVDPSSHSPVNPPRDQHATDTADEKPRAASPALSDASGPPTPDIPLSPGGTHARDPDADPDSPDLDSMWSASVIPNALPSHILAETFERHLRGLLRGVRAPLAIGPLWARLDYLCSLAVVLEEAGMVDRGLGRHLWRLTRRGPPAAADAVAPRPLMGFYEAATQNQADCQLWALLRRGLTTASTLRWGPQGPCFSPQWLKHNASLRPDVQSSAVMFGRVNEPTARSLLFRYCVGRADDGGEAGADTRRFIFHEPSDLAEENVHTCGVLMDGHTGMVGASLDILVCPRDIHGYLAPVPKTPLAFYEVKCRAKYAFDPMDPSDPTASAYEDLMAHRSPEAFRAFIRSIPKPSVRYFAPGRVPGPEEALVTQDQAWSEAHASGEKRRCSAADRALVELNSGVVSEVLLFGAPDLGRHTISPVSWSSGDLVRREPVFANPRHPNFKQILVQGYVLDSHFPDCPPHPHLVTFIGRHRTSAEEGVTFRLEDGAGALGAAGPSKASILPNQAVPIALIITPVRIDPEIYKAIQRSSRLAFDDTLAELWASRSPGPGPAAAETTSSSPTTGRSSR

UL12

Alkaline nuclease

620 amino acids

Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity.

Belongs to the herpesviridae alkaline nuclease family.

66.2 kDa

MAAAATPGAKRPADPARDPDSPPKRPRPNSLDLATVFGPRPAPPRPTSPGAPGSHWPQSPPRGQPDGGAPGEKARPASPALSEASSGPPTPDIPLSPGGAHAIDPDCSPGPPDPDPMWSASAIPNALPPHILAETFERHLRGLLRGVRSPLAIGPLWARLDYLCSLVVSLEAAGMVDRGLGRHLWRLTRRAPPSAAEAVAPRPLMGFYEAATQNQADCQLWALLRRGLTTASTLRWGAQGPCFSSQWLTHNASLRLDAQSSAVMFGRVNEPTARNLLFRYCVGRADAGVNDDADAGRFVFHQPGDLAEENVHACGVLMDGHTGMVGASLDILVCPRDPHGYLAPAPQTPLAFYEVKCRAKYAFDPADPGAPAASAYEDLMARRSPEAFRAFIRSIPNPGVRYFAPGRVPGPEEALVTQDRDWLDSRAAGEKRRCSAPDRALVELNSGVVSEVLLFGVPDLERRTISPVAWSSGELVRREPIFANPRHPNFKQILVQGYVLDSHFPDCPLQPHLVTFLGRHRAGAEEGVTFRLEDGRGAPAGRGGAPGPAKASILPDQAVPIALIITPVRVEPGIYRDIRRNSRLAFDDTLAKLWASRSPGRGPAAADTTSSPPTAGRSSR

UL12

Alkaline nuclease

520 amino acids

Plays a role in processing non linear or branched viral DNA intermediates in order to promote the production of mature packaged unit-length linear progeny viral DNA molecules. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Additionally, forms a recombinase with the major DNA-binding protein, which displays strand exchange activity.

Belongs to the herpesviridae alkaline nuclease family.

57.806 kDa

MSSTRHGGNFQLELAAGTLLPKEMPGINAFTFYDYLLDLAQSGASPESVLSVEPIYHRLAYISRLVAWIDASGFSHGTLPRLFLSTEPPTAEQIKSNLSPSDIEQILFFVESETKQQVGCDLWKVLRQFLLTASTLKWVKNRPCSKPDWFKVNEFRNGGAGYARQAMAITFGLTNESCARKLIMTYVSGDLHRHQNDSGEFFRLDVGESDEDAFSCGLLLDKRSGMLGASMDMAVMRKDPETAAVAEIDVFEIKCRAKYTFCPENLMHPLSACYERMLDSPGEETIRDFLFGIRAPGVEYFPPDSVPSAAEALLTCAKGWASPDAKASTRDRGSLIEKRHLQLNREVRSTVYLFGEPCLKTNSIRPIVWPSGGTSCELPIFINPKHQNFKQIFVQTYVLADYYPDAKISQYLVTFIGRSRRANEFGRVLRLDGGREDLAEPISLDHIHAIPILLIKTPVVIDRDHFSDLSSLGKEAFEFSVKETWGNAADAAAAPRIGRGCAAKKPGPTELLCAPESTQH

UL12

Alkaline nuclease

150 amino acids

Belongs to the baculo-herpesviridae alkaline nuclease family.

15.426 kDa

single

MAALVLPNSLPEELAARTFLRFLRGAPRPAAGGAAPLAYRLAYVHDLLVELARHGLAAPDAAAAAFGGARPPPAPAGVPAAAARAAILTVEAATRAQSESDLWTLLRRGLATASTVRWGADGPHFPPTWCEASTARCGTPDNAALIFGRV

UL12

Uncharacterized protein UL12

73 amino acids

8.25 kDa

MLLVFLGPVNSFMKGIRDVGFGKPPRILSVSRARLASNTSKACPPRQLARSWRFTVISCNHFLRDLLTDRFEG