UGT1A3

Gene

UGT1A3

Protein

UDP-glucuronosyltransferase 1-3

Organism

Homo sapiens

Length

534 amino acids

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

Similarity

Belongs to the UDP-glycosyltransferase family.

Mass

60.338 kDa

Sequence

MATGLQVPLPWLATGLLLLLSVQPWAESGKVLVVPIDGSHWLSMREVLRELHARGHQAVVLTPEVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

Protein

UDP-glucuronosyltransferase 1-3: UGT1A3

Gene

Ugt1a3

Protein

UDP-glucuronosyltransferase 1-3

Organism

Rattus norvegicus

Length

531 amino acids

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Similarity

Belongs to the UDP-glycosyltransferase family.

Mass

60.14 kDa

Sequence

MGIQGFLQKLSGLLLLLCALPWAEGGKVLVFPMEGSHWLSIRDVVRELHARGHQAVVLAPEVTVHIKEEDFFTLQTYPVPYTKEEYRHHLLGHLQNFFETEFSLKLVLQTMAAVNNVSTFYVRSCRGLLHNTALIQSLNSSSFDVVLTDPFFPCGAVLAMYLRVPAVFFLQSMLCELEFEATNSPNPSSYIPRLLTLNSDHMSFLDRVKNMLYPVPWMYLCHVNYGSLARLASDLLQREVSVVEILRHASVWLLRKDFVFHYPRPFMPNMVFIGGINCANRKPLSQEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTLLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKTH

Protein

UDP-glucuronosyltransferase 1-3: Ugt1a3