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UBI1

Gene
UBI1
Protein
Polyubiquitin
Organism
Candida albicans
Length
229 amino acids
Function
Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
Similarity
Belongs to the ubiquitin family.
Mass
25.755 kDa
Sequence
MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRSRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGF

Gene
UBI1
Protein
Ubiquitin-60S ribosomal protein L40
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
129 amino acids
Function
60S ribosomal protein L40: component of the 60S subunit of the ribosome.
Similarity
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
Mass
14.653 kDa
Sequence
MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCEKQICRKCYARLPPRATNCRKRKCGHSSQIRPKKALKK

Gene
UBI1
Protein
Ubiquitin-60S ribosomal protein L40
Organism
Chlamydomonas reinhardtii
Length
128 amino acids
Function
60S ribosomal protein L40: component of the 60S subunit of the ribosome.
Similarity
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
Mass
14.7 kDa
Sequence
MQIFVKTLTGKTITLEVESSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGIIEPSLQALARKYNQEKMICRKCYARLHPRAKNCRKKSCGHTNQLRPKKKLK

Gene
ubi1
Protein
Ubiquitin-60S ribosomal protein L40
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
128 amino acids
Function
60S ribosomal protein L40: component of the 60S subunit of the ribosome.
Similarity
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
Mass
14.595 kDa
Sequence
MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCEKQICRKCYARLPPRATNCRKKKCGHTNQLRPKKKLK