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UBE2M

Gene
ube2m
Protein
NEDD8-conjugating enzyme Ubc12
Organism
Dictyostelium discoideum
Length
230 amino acids
Function
Accepts the ubiquitin-like protein nedd8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins.
Similarity
Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
Mass
26.066 kDa
Sequence
MFRLKELQKKQQQQQQQQQQAAAPATNGTDAVTTEPTDVKRQNSNDLKEIRKQKSKDSYFSLKTKQSSESGSKRANPAELRAQKDIDEMEVPTGCAVSFKDTNDILNFNLSITPTDGLYQSATFQFTINIPSTYPYDPPKVHCDTLVYHPNIDLEGHVCLNILRQDWMPVLNIGTVIFGLMTLFLEPNPDDPLNKDAAQLMIDNKKTFEANVRQSLRGGYISNRQFPKLL

Gene
UBE2M
Protein
NEDD8-conjugating enzyme Ubc12
Organism
Bos taurus
Length
183 amino acids
Function
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation (By similarity).
Similarity
Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
Mass
20.9 kDa
Sequence
MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNFKLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFERCLK

Gene
UBE2M
Protein
NEDD8-conjugating enzyme Ubc12
Organism
Homo sapiens
Length
183 amino acids
Function
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
Similarity
Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
Mass
20.9 kDa
Sequence
MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNFKLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFERCLK

Gene
Ube2m
Protein
NEDD8-conjugating enzyme Ubc12
Organism
Mus musculus
Length
183 amino acids
Function
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation (By similarity).
Similarity
Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
Mass
20.9 kDa
Sequence
MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNFKLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFERCLK

Gene
ube2m
Protein
NEDD8-conjugating enzyme Ubc12
Organism
Xenopus laevis
Length
183 amino acids
Function
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx1, but not rbx2, suggests that the rbx1-ube2m complex neddylates specific target proteins, such as cul1, cul2, cul3 and cul4. Involved in cell proliferation (By similarity).
Similarity
Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
Mass
20.953 kDa
Sequence
MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDITELNLPKTCEIEFSDHDDLLNFKLVICPDEGFYKGGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFERCLK

Gene
ube2m
Protein
NEDD8-conjugating enzyme Ubc12
Organism
Xenopus tropicalis
Length
183 amino acids
Function
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx1, but not rbx2, suggests that the rbx1-ube2m complex neddylates specific target proteins, such as cul1, cul2, cul3 and cul4. Involved in cell proliferation (By similarity).
Similarity
Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
Mass
20.966 kDa
Sequence
MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCEIEFSDHDDLLNFKLVICPDEGFYKGGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFERCLK