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UBE2J2

Gene
UBE2J2
Protein
Ubiquitin-conjugating enzyme E2 J2
Organism
Bos taurus
Length
259 amino acids
Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).
Similarity
Belongs to the ubiquitin-conjugating enzyme family.
Mass
28.848 kDa
Sequence
MSSNSVKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEWHYVVRGPEMTPYEGGYYHGKLIFPREFPFKPPSIYMITPNGRFKCNTRLCLSITDFHPDTWNPAWSVSTILTGLLSFMVEKGPTLGSIETSDFTKRQLAAQSLVFNLKDKVFCELFPEVVEEIKQKQKAQDELSSRPQALPLPDVVPDGETHHGQHGLPLLNGHAPGAGPHLAGLQQANRHHGLLGGALANLFVIVGFAAFAYTVKYVLRSIAQE

Gene
UBE2J2
Protein
Ubiquitin-conjugating enzyme E2 J2
Organism
Homo sapiens
Length
259 amino acids
Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).
Similarity
Belongs to the ubiquitin-conjugating enzyme family.
Mass
28.898 kDa
Sequence
MSSTSSKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEWHYVVRGPEMTPYEGGYYHGKLIFPREFPFKPPSIYMITPNGRFKCNTRLCLSITDFHPDTWNPAWSVSTILTGLLSFMVEKGPTLGSIETSDFTKRQLAVQSLAFNLKDKVFCELFPEVVEEIKQKQKAQDELSSRPQTLPLPDVVPDGETHLVQNGIQLLNGHAPGAVPNLAGLQQANRHHGLLGGALANLFVIVGFAAFAYTVKYVLRSIAQE

Gene
Ube2j2
Protein
Ubiquitin-conjugating enzyme E2 J2
Organism
Mus musculus
Length
259 amino acids
Function
In case of infection by the murid herpesvirus 4, its association with the viral E3 ligase K3 mediates ubiquitination of host surface class I (MHC-I) H-2D(b)/H2-D1 and H-2K(b)/H2-K1 molecules before they exit the endoplasmic reticulum, leading to their degradation by the ERAD system, thus blocking the immune detection of virus-infected cells. The complex formed with the murid herpesvirus 4 protein K3 mediates ubiquitination of lysine, as well as serine and threonine residues present in the cytoplasmic tail of surface class I molecules and promotes ubiquitination of hydroxylated serine or threonine residues via ester bonds instead of the classical isopeptide linkage.
Similarity
Belongs to the ubiquitin-conjugating enzyme family.
Mass
28.954 kDa
Sequence
MSNNSNKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEWHYVVRGPEMTPYEGGYYHGKLIFPREFPFKPPSIYMITPNGRFKCNTRLCLSITDFHPDTWNPAWSVSTILTGLLSFMVEKGPTLGSIETSDFTKKQLAAQSLVFNLKDKVFCELFPEVVEEIKQKQKAQDELSNRPQNLPLPDVVPDGELHRGQHGIQLLNGHAPAAGPNLAGLPQANRHHGLLGGALANLFVIVGFAAFAYTVKYVLRSIAQE

Gene
ube2j2
Protein
Ubiquitin-conjugating enzyme E2 J2
Organism
Dictyostelium discoideum
Length
241 amino acids
Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum.
Similarity
Belongs to the ubiquitin-conjugating enzyme family.
Mass
27.154 kDa
Sequence
MSTQVCVTRLKKELLALSKNEDIKDIFIAKPSISNILEWHYVIYGPPDTPYHGGYYHGQIIFPVEYPYKPPSILMTTPSGRFVCNSRICTSMSDFHPDTWSPFWSNCTIILGLISFMTEDENGFGSIVKSKETRKQLASQSMAFNLKNPVFVKLFPELISDYKKKGTFYSSSSTPSSTPPPSSTPSSSSSSSNISKRNVPIPTTKTTPQDTNKKKEQKNNNIPYIILFIALIIILLYLFLK