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Terf2ip

Gene
terf2ip
Protein
Telomeric repeat-binding factor 2-interacting protein 1
Organism
Danio rerio
Length
616 amino acids
Function
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similarity).
Similarity
Belongs to the RAP1 family.
Mass
68.075 kDa
Sequence
MSKKKEASKISPVLFLDPGGQSMRFYVRPGPTKMQLHPLITSGGGNLCRNQEPGAILLIDPTDATNVTQNTGQKYISTKYILDCVEQNQQLDPNDYAIIIGPSVQTRMALRNQGSGRLGYSSEEDAAILKFIEKRQQDAKGNLVWKEMEKRHVTEHSWQSMKDRFLKHLQQKLADKPTKKSPIKRKPLSFTQSPLRKKKVVEISEDESVQKGDCPEAPMATETGSINPPASPERASSPPEEPQAAGQPSQASSNDSQDETCVLVIETPESENPRLDEDAPDASNEHSSLKKKRRKTCKTSTTDSRSSRLEEDPVGQDIPDESNAQSSPKKKRQKACKTSTTDSRSSRLEENPDRRDIPDESTEQSSPNKSQMTSKISTSDSGNPIGDQGCDNPHGCNANSSPSKTRQTNSEASTPDSKKLGILAKAAKEFEDSDVMDDSEECENPCEVPIAEPSDAQESSATPATLVREPESQAEHHEETQPDSPMSEEERPGPSSAVVPPSLNSSTSCSHIRETPEETLSRDLLEVKEQVINLMRETKKDLVEVTKALLKASGDLKRAQVFLLNGYDHETHGPLWTRLDDETLLAADPYELEQLQSKFGEEEVTRRKSFLATDVK

Gene
terf2ip
Protein
Telomeric repeat-binding factor 2-interacting protein 1
Organism
Xenopus laevis
Length
513 amino acids
Function
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similarity).
Similarity
Belongs to the RAP1 family.
Mass
57.071 kDa
Sequence
MATLGGLTHSHTLFVEDDGTPVRFYIPPGPLKRQLYQLIIHGGGEMCRLQQPGALLLSTPGSAQGAQYVSTAYVMDCVRKGELLHVDDYRLDGSHGRKRQSKGMKQDEREGESSHGSDGKEQVKVGEGPEEEDELSDLGELVIEEGLEEDEQESDTVKIKKENKMDCSEAQKIGSLKSARIHQTGRNPFTEEEDVAILVYVRDNAPHRGTVTGIALWKEMEQRRVLKRTWQAIKDRYIKHLKGKQGYRLPLSAASRSHDPSEDESPQPITKKSRTNTSTPWTKRPGNIGRTSEKLGTALPMEKSSTKAPAEQSDAVESTSINFPLEKRGQHVTKGVVRRSEGEKKSSDMSKGAVSATSKEDQEDGGDLHIFEIANMEFEVDDTPEIELPKRSLSLREFVMGEDPPSSQSQTQVDEVSSSPEDSESEGLQEALLGMMSEFKLRLRDVTQALLKNNGELSATRHFLRTGSRPDGFPIWIRKDDLDLQKADAETQKRLIQKYGSDNVAKRVAFLAS

Gene
terf2ip
Protein
Telomeric repeat-binding factor 2-interacting protein 1
Organism
Xenopus tropicalis
Length
509 amino acids
Function
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similarity).
Similarity
Belongs to the RAP1 family.
Mass
56.249 kDa
Sequence
MAALGGLTHSRTLFVDDDGTPMSFYVPPGPLKRQLYPLITHGGGEMCRMQQPGALLLSAPGSAQGAQYVSTAYIMDCVRIDKLLDVDDYRLDGSHGRPRKSQGSKKEERAPQQKVGESSQESDQKQQAKVGGDLEEGDKLSDPGEPVNEESLGSVSSTRKKENKMDCSEAQKIGSLKSARIHQTRRNVFTEKEDVAIMLYVRENAPHRGTGVSLWKEMEQKQVVKRTWQAIKNRYFRYLKGKRNYVLPLTDDSSSQEPSDDEEECPQPITKKSRISDSTPCTEKPGVAEKTGEKLSTDTSVEGPSTEKSDAAKTSNVNLPVEERGQEVTEGAIKRSEGNKKSTEMNEEAVSASSKENQDDGADLHIFEIANLEFEVEDTPELEVPKRSFGLKEFVMGEDLPSSQSQTQVDEVSSSPDASESEGLQEALLSMMSEFKLSLCDVTQALLKNNGELAATRHFLQTGSRPDGYPIWVRKDDLDLQKDDAETLKRLIQKYGADNVAKRVAFLAS

Gene
TERF2IP
Protein
Telomeric repeat-binding factor 2-interacting protein 1
Organism
Macaca fascicularis
Length
400 amino acids
Function
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity).
Similarity
Belongs to the RAP1 family.
Mass
44.369 kDa
Sequence
MAEAMDLGKDPNGPTHSSTLFVREDGSSMSFYVRPSPAKRRLSTLILHGGGTVCRVQEPGAVLLAQPGEALAEASGDFISTQYILDCVERNERLELEAYRLGSASAADTGSEAKPGALAEGAAEPEPQRLAGRIAFTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGDAPVSPSSQKLKRKAEEDPEAADSGEPQNKRTPDLPEEEYVKEEIQENEEAVKKMLVEATREFEEVVVDESPPDFEIHITMCDDDPPTPEEDSETQPDEEEEEEEEEKVSQPEVGAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSAFLASGQRADGYPIWSRQDDIDLQKDDEDTREALVKKFGAQNVARRIEFRKK

Gene
TERF2IP
Protein
Telomeric repeat-binding factor 2-interacting protein 1
Organism
Bos taurus
Length
399 amino acids
Function
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity).
Similarity
Belongs to the RAP1 family.
Mass
44.221 kDa
Sequence
MAEAMELGKDPNGPTHSSTLFVREDGSSMSFYVRPSPAKRRLSTLILHGGGTLCRVQEPGAVLLAQPGEAAAEASGDFISTQYILDCVERNEKLELEAYRLGPAPAAYQAPETKPGVLAGGVAAAEPEPQSQAGRMVFTDADDVAIITYVKEHARSASSVTGNALWKAMEKSSLTQHSWQSMKDRYLKRLRGQEHKYLLGEAPVSPSSQKLKRKAEQDPEAADSGEPQNKRTPDLPEEEFEKEEIKENEAAVKKMLVEATREFEEIVVDESPDFEIHITMCDDDPCTPEEDSETQPDEEEEEEEKVSAPEVGAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSSFLESGQRADGYPIWSRQDDLDLQKDDEATRDALVKKFGAQNVARRIEFRKK

Gene
TERF2IP
Protein
Telomeric repeat-binding factor 2-interacting protein 1
Organism
Homo sapiens
Length
399 amino acids
Function
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
Similarity
Belongs to the RAP1 family.
Mass
44.26 kDa
Sequence
MAEAMDLGKDPNGPTHSSTLFVRDDGSSMSFYVRPSPAKRRLSTLILHGGGTVCRVQEPGAVLLAQPGEALAEASGDFISTQYILDCVERNERLELEAYRLGPASAADTGSEAKPGALAEGAAEPEPQRHAGRIAFTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGDAPVSPSSQKLKRKAEEDPEAADSGEPQNKRTPDLPEEEYVKEEIQENEEAVKKMLVEATREFEEVVVDESPPDFEIHITMCDDDPPTPEEDSETQPDEEEEEEEEKVSQPEVGAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSAFLASGQRADGYPIWSRQDDIDLQKDDEDTREALVKKFGAQNVARRIEFRKK

Gene
Terf2ip
Protein
Telomeric repeat-binding factor 2-interacting protein 1
Organism
Rattus norvegicus
Length
393 amino acids
Function
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity).
Similarity
Belongs to the RAP1 family.
Mass
43.418 kDa
Sequence
MAEVMDLGKDPNGPTHSSTLFVREDGSAMSFYVRPSSAKRRLSTLILHGGGILCRVQKPGAVLLAQPGEALAEASGDFISTQYILDCVERNEKLELEAYRLGLTEQASDPKPGASAEGSTEPEPQPLTGRIAYTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLQGQEHKYLLGNAPVSPSSQKLKRKAEQDPEAADSGEPQNKRTPDLPEEECVKGETKENGEADNKLFEEATPELGEAVVDESPDFEIHITMCDGDPPTPEEDSETQPDEEEEEPKVSTQEVGTAIKIIRQLMEKFNLDLSTVTQALLKNSGELEATSSFLESGRRPDGFPIWCRQDDLDLQKDDDDTRNALVKKYGAQNVARRIEFRKK

Gene
Terf2ip
Protein
Telomeric repeat-binding factor 2-interacting protein 1
Organism
Mus musculus
Length
393 amino acids
Function
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
Similarity
Belongs to the RAP1 family.
Mass
43.353 kDa
Sequence
MAEAMDLGKDPNGPTHSSTLFVREDGSAMSFYVRPSSAKRRLSTLILHGGGTVCRVQEPGAVLLAQPGEALAEASGDFISTQYILDCVDRNEKLDLEAYRLGLTEQASDPKPGASTEGSTEPEPQPLTGRIAYTDAEDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGNAPVSPSSQKLKRKAEQDPEAADSGEPQNKRAPDLPEEECVKGEIKENGEADNKLFEEAAPEFGEAVVDESPDFEIHITMCDGDPPTPEEDSETQPDEEEEEPKVSTQEVGTAIKVIRQLMEKFNLDLSTVTQALLKNSGELEATSSFLESGRRPDGYPIWCRQDDLDLQKDDDDTKNALVKKFGAQNVARRIEFRKK

Gene
TERF2IP
Protein
Telomeric repeat-binding factor 2-interacting protein 1
Organism
Gallus gallus
Length
329 amino acids
Function
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similarity).
Similarity
Belongs to the RAP1 family.
Mass
36.182 kDa
Sequence
MAAPPRKVFVWEDGTPMRFYIRPGMAKLRLAPLLLAGGAGLCRVQEPGAVHLVQPGEPAPDGAVSTDYVVACVESQRRLPLDLYRHSGPAPLAASPRGRLPFTEAEDAALLRAVRERSGAPRVSGTALWKELECTGLTRHSWQAMRDRYLRHLRPLHRESQQTEEAAAPMGIFEAANREFESSESGSDTSDTPDELPLQNGEGTFPLEAASGLQTGLDDCALPAAQGENKQTNTFSDSSKAEEAAQIIQHFMEEFHTDLLTVTQALLKNSGEVEATSYYLHAGQRLDGYPVWSREDDLELQKDDEDVRSKLIAKFGAENVARRVAFRKS