Function
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to the consensus sequence CAC/GCTGT/C present, in the chymotrypsin, insulin, AP-4, and several other gene enhancer motifs (PubMed:2200736).
Sequence
MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKGRPASLAGTQFAGSGLEDRPSSESWGNSEQNSSSFDPSRAYSEGAHFSDSHSSLPPSTFLGAGLGGKGSERNAYATFGRDTSVGTLSQAGFLPGELGLSSPGPLSPSGVKSSSQYYTSFPSNPRRRAADGGLDTQPKKVRKVPPGLPSSVYPSSSGDNYSRDATAYPSAKTPSSAYPSPFYVADGSLHPSAELWSPPGQVGFGPMLGDGSAPLPLAPGSSSVSSGAFGGLQQQDRMGYQLHGSEVNGTLPAVSSFSAAPGTYSGTSGHTPPVSGADSLLGTRGTTASSSGDALGKALASIYSPDHSSNNFSPSPSTPVGSPQGLPGTSQWPRAGAPSALSPNYDAGLHGLSKMEDRLDEAIHVLRSHAVGTASELHGLLPGHSTLTTSFAGPMSLGGRHAGLVSGSHPEDGLTSGASLLHNHASLPSQPSSLPDLSQRPPDSFSGLGRAGVTAGASEIKREEKEDEEVTSVADAEEDKKDLKVPRTRTSPDEDEDDLLPPEQKAEREKERRVANNARERLRVRDINEAFKELGRMCQLHLSTEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQLALSAAHPGLGEAHNPAGHL