Protein
Vitamin B12-dependent ribonucleoside-diphosphate reductase
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Similarity
Belongs to the ribonucleoside diphosphate reductase class-2 family.
Sequence
MIKEVVKRDGTVVPFEKNKITMAIYKAMLSVKNGTMKDAEQLADKVVARLKDKERPSVEEIQDVVEDVLMTSKIDGKTFTDVAKSYILYREKRRAIREEKELMGVKDDLKLTLNAVKVLEARYLLKDEDGKIIETPRQMFRRVASHIGIVEALYDYIKYKKTGKVPENAEIIGKVSPTQEEVLRRAFGYMKEDGIIEGTFEEFMDFIQTKGTSAGHYINRFEEVMSSLDFVPNSPTLMNAGTKLGQLSACFVLPVGDSIEDIFETLKNTALIHKSGGGTGFSFSRLRPKDDIVGSTKGVASGPVSFMKIFDVTTDVIKQGGKRRGANMGILNYNHPDIMEFILSKDSENKVLSNFNISVGVTDDFFDKLDNDDYVDLVNPRTKKIMKRIKAREIWDAIIDQAWKTADPGLIFLDEINRKNPVKNVGDIESTNPCGEQPLLPYESCNLGSINLSKYVVDGKKIDFDRLRETVWTATRFLDDVIDANKFPVEQIKKVTRMTRKIGLGVMGFADMLIKLEIPYNSWEALEIGEKVMSFINDESHKASQALAEERGVFPAWYGSEWEKEGIKMRNSTTTTIAPTGTISIIAGCSSSIEPIFALAFVRHVLNGQELLEVNPLFEEKTRELGIYSEELMRQVAETGNLENVKINEEVKKIFVTAHEIDPQWHVLMQATFQRYCDSGVSKTINMRSDATREDIARAYRMAKDLHCKGITVYRDKSKTVQVLTAGTAETKKPEEKEVIELVTKMPDKYLKIDSTFDPACPTGKCDK