Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Function
Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
Similarity
Belongs to the archease family.
Sequence
MDSDDNRTLSYEVVDHESDIGVIVYGKTYEELFSNAVYAMADLIVDVSRLKENRKMHEVITGKTPEDIMVNLLSRVLFYLDTYYILYYRITSKYSDGELDAYFYGSEIPEGIEYRNVIKAVTYSDLAVKPEEGYAKIIFDL