Protein
Testis-specific Y-encoded-like protein 5
Function
Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7 (By similarity).
Similarity
Belongs to the nucleosome assembly protein (NAP) family.
Sequence
MSGRSRGRKSSRAKGRGKGRARARVRAAAEDAWHDEKPPQSPRLGEDSAAAQVQAGAAQGGAEPAELREEAACRLPLDCGLALRARAADERGLAAPDPDLERARSLAERLTSDTSFVGTVGALAKLRRGSRIGNRRVPGRKAPDTRSATGRGPQATVSGKPKMASAGLCAAAPVGEEKKMTEKHAGAGSPATVGSMDTLETVQLKLETMNAQADRAYLRLSRKFGQLRLHHLERRNLLIQSIPGFWGQAFQNHPQLSAFLNTKDKEVLSYLNRLEVEELGLARLGYKIKFYFGRNPYFQNKVLIKEYGCGPSGQVVSRSAPIQWLPGHDLQSLSKENPENNGSFFGWFSNHSSIESDKIVEIINEDLWPNPLQYYLISEEARGEKGKEERPGPAKLSPAPAVRQPN