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TSHR

Gene
tshr
Protein
Thyrotropin receptor
Organism
Ictalurus punctatus
Length
778 amino acids
Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:19523396). Also acts as a receptor for the heterodimeric glycoprotein hormone thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism (By similarity).
Similarity
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Mass
87.36 kDa
Sequence
MRLFALVLIFFFSTRTCTEDVKSCPNGCECTDWKGYYVSCTDIATLPIFPGNTETLRLYETRLSSVPQDAFVNMVNISLIYLSVDVTLRSLEKHSFFNLKKITHVEIRNTRSLMSIDPEAFKDLPELKYLGLFNTGLTIFPALTRIHSHESNFMLEITDNLYITEIPANAFQGITKDALTVMLYSNGFTKIQHHAFNGTKLDAIYLHRNKELTELSEDMFAETISGPVLLDVSDSGVTSLPATGLESLRELSARNVWALKKLPSVKTFRHLIGADMTYPSHCCAFKNLKKKKGYLDYIICNLTAMRGQHYERSVGRITVPAVMDGTDKGIDISDPLLGNTYDHHDFLRSLHYHEFLGGHADYDMGFGDTLKNPQIATSQDFDSHYDYVVCEDGEAVTCAPAPDDFNPCEDIMGFSFLRVSVWFVSLLAVLGNMVVLFVLLTSHYKLSVSRFLMCHLAIADLCMGIYLLLIASVDLYTQSEYYNHAIDWQTGPWCTLAGFISIFATELSVYTLTTITLERWHAINFAMQLDRKLRLSHASAVMLGGWLLCLLLALMPVLGVSSYQKVSICLPMSTQNLLDQVYILFILVINIVAFVAICACYIKIYCAVHNPNYTSSRKDSSIAKRMAVLIFTNFLCIAPISFYAISAALDHPLITISNSKILLVLFYPLNSCANPFLYAIFTKAFQGDVFILLSKIGLCEQQAKLFRGQTISTRASSGDTNRRGIKTKILTRWNVQATATCHQSSVNKDNNTSRGRKCEPTANKSKHIQGMNSTMVFY
Protein
Thyrotropin receptor: tshr

Gene
TSHR
Protein
Thyrotropin receptor
Organism
Canis lupus familiaris
Length
764 amino acids
Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Similarity
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Mass
86.483 kDa
Sequence
MRPPPLLHLALLLALPRSLGGKGCPSPPCECHQEDDFRVTCKDIHRIPTLPPSTQTLKFIETQLKTIPSRAFSNLPNISRIYLSIDATLQRLESHSFYNLSKMTHIEIRNTRSLTSIDPDALKELPLLKFLGIFNTGLGVFPDVTKVYSTDVFFILEITDNPYMASIPANAFQGLCNETLTLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLSAIDKDAFGGVYSGPTLLDVSYTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSIRSLRQRKSVNTLNGPFDQEYEEYLGDSHAGYKDNSQFQDTDSNSHYYVFFEEQEDEILGFGQELKNPQEETLQAFDSHYDYTVCGGNEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLIVLLTSHYKLTVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIVAFIIVCSCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVSPKNSAGIQIQKVTRDMRQSLPNMQDEYELLENSHLTPNKQGQISKEYNQTVL
Protein
Thyrotropin receptor: TSHR

Gene
TSHR
Protein
Thyrotropin receptor
Organism
Homo sapiens
Length
764 amino acids
Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity).
Similarity
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Mass
86.83 kDa
Sequence
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHDMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
Protein
Thyrotropin receptor: TSHR

Gene
Tshr
Protein
Thyrotropin receptor
Organism
Mus musculus
Length
764 amino acids
Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Similarity
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Mass
86.583 kDa
Sequence
MRPGSLLLLVLLLALSRSLRGKECASPPCECHQEDDFRVTCKELHRIPSLPPSTQTLKLIETHLKTIPSLAFSSLPNISRIYLSIDATLQRLEPHSFYNLSKMTHIEIRNTRSLTYIDPDALTELPLLKFLGIFNTGLRIFPDLTKIYSTDIFFILEITDNPYMTSVPENAFQGLCNETLTLKLYNNGFTSVQGHAFNGTKLDAVYLNKNKYLTAIDNDAFGGVYSGPTLLDVSSTSVTALPSKGLEHLKELIAKDTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSIRNLRQRKSVNILRGPIYQEYEEDPGDNSVGYKQNSKFQESPSNSHYYVFFEEQEDEVVGFGQELKNPQEETLQAFESHYDYTVCGDNEDMVCTPKSDEFNPCEDIMGYRFLRIVVWFVSLLALLGNIFVLLILLTSHYKLTVPRFLMCNLAFADFCMGVYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYTIMAGGWVSCFLLALLPMVGISSYAKVSICLPMDTDTPLALAYIVLVLLLNVVAFVVVCSCYVKIYITVRNPQYNPRDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYQGQRVCPNNSTGIQIQKIPQDTRQSLPNMQDTYELLGNSQLAPKLQGQISEEYKQTAL
Protein
Thyrotropin receptor: Tshr

Gene
TSHR
Protein
Thyrotropin receptor
Organism
Sus scrofa
Length
764 amino acids
Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Similarity
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Mass
86.644 kDa
Sequence
MSLTPLLQLALLLALPRSLRGKGCPSPPCECHQEDDFRVTCKDIHSIPPLPPNTQTLKFIETHLKTIPSRAFSNLPNISRIYLSIDATLQQLESQSFYNLSKMTHIEIRNTRSLTYINPGALKDLPLLKFLGIFNTGLRIFPDLTKVYSTDVFFILEITDNPYMTSIPANAFQGLCNETLTLKLYNNGFTSVQGHAFNGTKLDAVYLNKNKYLTVIDKDAFGGVFSGPTLLDVSYTSVTALPPKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSIRSLRQRKSVNAVNGPFYQEYEEDLGDSSVGNKENSKFQDTHSNSHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTVCGGSEDMVCTPKSDEFNPCEDIMGYRFLRIVVWFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGMYLLLIASVDLYTQSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYAIMAGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIVAFTIVCSCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGFCKRQAQAYRGQRVSPKNSTGIQVQKVTQNMRQSLPNMQDDYELLENSHLTHKKHDQISKEYKQPVL
Protein
Thyrotropin receptor: TSHR

Gene
Tshr
Protein
Thyrotropin receptor
Organism
Rattus norvegicus
Length
764 amino acids
Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:1696008). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Plays a central role in controlling thyroid cell metabolism (PubMed:12045258).
Similarity
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Mass
86.475 kDa
Sequence
MRPGSLLQLTLLLALPRSLWGRGCTSPPCECHQEDDFRVTCKELHQIPSLPPSTQTLKLIETHLKTIPSLAFSSLPNISRIYLSIDATLQRLEPHSFYNLSKMTHIEIRNTRSLTYIDPDALTELPLLKFLGIFNTGLRIFPDLTKIYSTDVFFILEITDNPYMTSVPENAFQGLCNETLTLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTAIDKDAFGGVYSGPTLLDVSSTSVTALPSKGLEHLKELIAKNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSIRNLRQRKSVNVMRGPVYQEYEEGLGDNHVGYKQNSKFQEGPSNSHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTVCGDNEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSPMALLGNVFVLFVLLTSHYKLTVPRFLMCNLAFADFCMGVYLLLIASVDLYTHTEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYTIMAGGWVSCFLLALLPMVGISSYAKVSICLPMDTDTPLALAYIALVLLLNVVAFVIVCSCYVKIYITVRNPQYNPRDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSGVLLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGLCKHQAQAYQAQRVCPNNNTGIQIQKIPQDTRQSLPNVQDTYEPLGSSHLTPKLQGRISEEYTQTAL
Protein
Thyrotropin receptor: Tshr

Gene
TSHR
Protein
Thyrotropin receptor
Organism
Ovis aries
Length
764 amino acids
Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Similarity
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Mass
86.674 kDa
Sequence
MRPTPLLRLALLLVLPSSLWGERCPSPPCECRQEDDFRVTCKDIQRIPSLPPSTQTLKFIETHLKTIPSRAFSNLPNISRIYLSIDATLQQLESHSFYNLSKVTHIEIRNTRSLTYIDSGALKELPLLKFLGIFNTGLRVFPDLTKIYSTDVFFILEITDNPYMTSVPANAFQGLSNETLTLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTVIDQDAFAGVYSGPTLLDISYTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKNIRGILQSLMCNESSIWGLRQRKSASALNGPFYQEYEEDLGDGSAGYKENSKFQDTHSNSHYYVFFEDQEDEIIGFGQELKNPQEETLQAFDNHYDYTVCGGSEEMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGLYLLLIASVDLYTQSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMHLDRKIRLWHAYVIMLGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIIAFIIVCACYVKIYITVRNPHYNPGDKDTRIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFMLLSKFGICKRQAQAYRGQRVSSKNSTGIRVQKVPPDVRQSLPNVQDDYELLGNSHLTPKQQDQTSKEYKQTVL
Protein
Thyrotropin receptor: TSHR

Gene
TSHR
Protein
Thyrotropin receptor
Organism
Bos taurus
Length
763 amino acids
Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Similarity
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Mass
86.431 kDa
Sequence
MRPTPLLRLALFLVLPSSLGGERCPSPPCECRQEDDFRVTCKDIQSIPSLPPSTQTLKFIETHLKTIPSRAFSNLPNISRIYLSIDATLQQLESHSFYNLSKVTHIEIRNTRSLTYIDSGALKELPLLKFLGIFNTGLRVFPDLTKIYSTDVFFILEITDNPYMTSIPANAFQGLCNETLTLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTVIGQDAFAGVYSGPTLLDISYTSVTALPSKGLEHLKELIARNTWTLRKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILQSLMCNESSIRGLRQRKSASALNGPFYQEYEDLGDGSAGYKENSKFQDTQSNSHYYVFFEEQEDEIIGFGQQLKNPQEETLQAFDSHYDYTVCGGSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGLYLLLIASVDLYTQSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWHAITFAMRLDRKIRLWHAYVIMLGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIIAFIIVCACYVKIYITVRNPHYNPGDKDTRIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFMLLSKFGICKRQAQAYRGQRVSPKNSTGIRVQKVPPDVRQSLPNVQDDYELLENSHLTPKQQDQTSKEYKRTVL
Protein
Thyrotropin receptor: TSHR

Gene
TSHR
Protein
Thyrotropin receptor
Organism
Felis catus
Length
763 amino acids
Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Similarity
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Mass
86.588 kDa
Sequence
MRQTPLLQLALLLSLPRSLGGKGCPSPPCECHQEDDFRVTCKDIHRIPSLPPSTQTLKFIETHLKTIPSRAFSNLPNISRIYLSIDATLQRLESHSFYNLSKMTHIEIRNTRSLTYIDPGALKELPLLKFLGIFNTGLGVFPDLTKVYSTDVFFILEITDNPYMTSIPANAFQGLCNETLTLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTAIDQDAFGGVYSGPTLLDVSYTSVTALPSKGLEHLKELIARNTWTLKKLPLTLSFLHLTRADLSYPSHCCAFKNQKKIRGILESFMCNDSSIRSLRQRKSVNALNGPFDQEYEEYLGDSHAGYKDNSKFQDTRSNSHYYVFFEEQDEILGFGQELKNPQEETLQAFDSHYDYTVCGGNEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLIILLTSHYKLTVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNAAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKMRLRHAYAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIVAFIIVCSCYVKIYITVRNPQYNTGDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKTFQRDVFILLSKFGICKRQAQAYRGQRVSPKNSTGIQVQKVTRNMRQSLPNMQDDYELLENSHLTPNKQSHISKEYNQTVL
Protein
Thyrotropin receptor: TSHR