Function
Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction (PubMed:19398037, PubMed:17846166 and PubMed:7721813). Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats (By similarity).
Sequence
MTEITAEGNASTTTTVIDSKNGSVPKSPGKVLKRTVTEDLVTTFSSPAAWLLVIALIITWSAVAVVMFDLVDYKNFSASSIAKMGSDPLKLVHDAVEETTDWIYGFFSLLSDIISSDGDEEDDEGDEDTAKGEIEEPPLKRKDIHKEKIEKQEKPERKIPTKVVHKEKEKEKEKVKEKEKPEKKATHKEKLEKKEKPETKTVTKEEKKARTKEKIEEKTKKEVKGVKQEKVKQTVAKAKEVQKTPKPKEKESKETAAVSKQEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPSPTEQASRPTPALPTPEEKEGEKKKAEKKVTTETKKKAEKEDAKKKSEKETDIDMKKKEPGKSPDTKPGTVKVTTQAATKKDEKKEDSKKAKKPAEEQPKGKKQEKKEKHEEPAKSTKKEHAAPSEKQAKAKIERKEEVSAASTKKAVPAKKEEKTTKTVEQETRKEKPGKISSVLKDKELTKEKEVKVPASLKEKGSETKKDEKTSKPEPQIKKEEKPGKEVKPKPPQPQIKKEEKPEQDIMKPEKTALHGKPEEKVLKQVKAVTTEKHVKPKPAKKAEHQEKEPPSIKTDKPKSTSKGMPEVTESGKKKIEKSEKEIKVPARRESHQLQNVTKAEKPARGSKEGFEDVPASKKAKEEAEEVSSTKKQKSPISFFQCVYLDGYNGYGFQFPVTPAQYPGESSGKPNSPGPKQ