Protein
Bifunctional isopimaradiene synthase, chloroplastic
Function
Involved in defensive oleoresin formation in conifers in response to insect attack or other injury (By similarity). Involved in diterpene (C20) olefins biosynthesis. Bifunctional enzyme that catalyzes two sequential cyclizations of geranylgeranyl diphosphate (GGPP) to isopimara-7,15-diene.
Similarity
Belongs to the terpene synthase family. Tpsd subfamily.
Sequence
HHLTANTQSIPHFSTTLNAGSSARKRRSLYLRWGKGSNKIIACVGEGATSVPYQSAEKNDSLYSSTLVKREFPPGFWKDDLIDSLTSSHKVAASDEKRIETLISEIKNMFRCMGYGETNPSAYDTAWVARIPALDGSDNPHFPETVEWILQNQLKDGSWGEGFYFLAYDRILATLACIITLTLWRTGETQVHKGIEFFRTQAGKMEDEADSHRPSGFEIVFPAMLKEAKILGLDLPYDLPFLKQIIEKREAKLKRIPTDVLYALPTTLLYSLEGLQEIVDWQKIMKLQSKDGSFLSSPASTAAVFMRTGNKKCLDFLNFVLKKFGNHVPCHYPLDLFERLWAVDTVERLGIDRHFKEEIKDALDYVYSHWDERGIGWARENPVPDIDDTAMGLRILRLHGYNVSSDVLKTFRDENGEFFCFLGQTQRGVTDMLNVNRCSHVSFPGETIMEEAKLCTERYLRNALENVDAFDKWAFKKNIRGEVEYALKYTWHKSMPRLEARSYIENYGPNDAWLGKTVYRMPYISNEKYLELAKLDFNKLQSIHQTELQDLRRWWKSSGFSKLNFTRERVTEIYFSSASFMFEPEFSKCREVYTKASIFTLIFDDLYDAHGSLDDLKLFSEAVKRWDLSLLERMPQEMKICFLGFYNTFNEIAEEVHKRQGRDMLGHIQNVWEILLAAYTKEAEWSKTKYVPSFDEYIENASVSITLGTIVLISTLFIGEVLTDHVLSKINHGSRFLHLMGLTGRLVNDTKTYQAERGQGEEASAIQCYMKDHPEISEEEALNHVYNVMENALQELNKEFVNNKEVPPNCRRLVFNTARIMQLFYMQGDGLTLSHDMEIKDHVKTCLFIPIA