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TNP2

Gene
TNP2
Protein
Nuclear transition protein 2
Organism
Macaca fascicularis
Length
141 amino acids
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Similarity
Belongs to the nuclear transition protein 2 family.
Mass
15.777 kDa
Sequence
MDTKTHSLPITHTQLHSNSRPQSRSQCTCTHHCQTFSQSCRQSQRGSRSRSSSQSPATHQNPTGAHSSSGCQSQSPNASPPPKRHKKTMNSHHSPTRPTILHSSCPKNRKNLEGKLNKKKMAKRIQQVYKTKKRSSGRKSN

Gene
TNP2
Protein
Nuclear transition protein 2
Organism
Pongo pygmaeus
Length
138 amino acids
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Similarity
Belongs to the nuclear transition protein 2 family.
Mass
15.585 kDa
Fragment
single
Sequence
MDTKTHSLPITHTQLHSNSQPQSRTCSPCTCTRHRQTFSQSCRQSQRGSWSQNSSQSPASHHNPTGAHSSSGHQSQSPNDSPPPKRHKKTMNSHHSPTRPTILHCSCPKNRKNFEGKLNKKKMAKRIQHVYKTKTRSS

Gene
TNP2
Protein
Nuclear transition protein 2
Organism
Homo sapiens
Length
138 amino acids
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Similarity
Belongs to the nuclear transition protein 2 family.
Mass
15.641 kDa
Sequence
MDTQTHSLPITHTQLHSNSQPQSRTCTRHCQTFSQSCRQSHRGSRSQSSSQSPASHRNPTGAHSSSGHQSQSPNTSPPPKRHKKTMNSHHSPMRPTILHCRCPKNRKNLEGKLKKKKMAKRIQQVYKTKTRSSGWKSN

Gene
TNP2
Protein
Nuclear transition protein 2
Organism
Sus scrofa
Length
137 amino acids
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Similarity
Belongs to the nuclear transition protein 2 family.
Mass
15.301 kDa
Sequence
MDTKTQSLPNAHTQPHSNSGPQSHACNQCSCSHHCQNCSQSCDRSQSCSRSRSSSQSPTGHRSLPGHQSQSLSPSPSPRHRKRAMHSHRCPSRPGTRSCSHSKKRKNVEGKANKRKGIKRSQQVYKTKRRSSGRKYN

Gene
TNP2
Protein
Nuclear transition protein 2
Organism
Macaca mulatta
Length
137 amino acids
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Similarity
Belongs to the nuclear transition protein 2 family.
Mass
15.414 kDa
Fragment
single
Sequence
MDTKTHSLPITHTQLHSNSRPQSRTCSQCTCTHHRQTFSQSCRQSQRGSRSRSSSQSPATHQNPTGAHSSSGLQSQSPNASPPPKRHKKTMNSHHSPTRPTILHSSCPKNRKNLEGKLNKKKMAKRIQQVYKTKKRS

Gene
TNP2
Protein
Nuclear transition protein 2
Organism
Pan troglodytes
Length
133 amino acids
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Similarity
Belongs to the nuclear transition protein 2 family.
Mass
14.947 kDa
Fragment
single
Sequence
MDTKTHSLPITHTQLHSNSQPQSCTCTRHRQTFSQSCRQSHCGSRSRSSSQSPASHRNPTGAHSSSGHQSQSPNTSPPPKRHKKTMNSHHSPMRPTILHCSCPKNRKNLEGKLKTKKMAKRIQQVYKTKTRSS

Gene
TNP2
Protein
Nuclear transition protein 2
Organism
Gorilla gorilla gorilla
Length
133 amino acids
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Similarity
Belongs to the nuclear transition protein 2 family.
Mass
15.052 kDa
Fragment
single
Sequence
MDTKTHSLPITHTQLHSNSQPQSRTCTRHCQTFSQSCRQSHRGSRSRSSSQSPASHRNPTGAHSSSGHQSQSPNTSPPPKRHKKTMNSHHSPRRPTILHCSCPKNRKNLEGKLKKKKMAKRIQQVYKTKTRSS

Gene
TNP2
Protein
Nuclear transition protein 2
Organism
Pan paniscus
Length
133 amino acids
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Similarity
Belongs to the nuclear transition protein 2 family.
Mass
14.925 kDa
Fragment
single
Sequence
MDTKTHSLPITHTQLHSNSQPQSCTCTHHRQTFSQSCRQSHRGSRSRSSSQSPASHRNPTGAHSSSGHQSQSPNTSPPPKRHKKTMNSHHSPMRPTLHCSCPKNRKNLEGKLKTKKMAKRIQQVYKTKTRSSG

Gene
TNP2
Protein
Nuclear transition protein 2
Organism
Bos taurus
Length
132 amino acids
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Similarity
Belongs to the nuclear transition protein 2 family.
Mass
15.241 kDa
Sequence
MDTKTQSLPNTHAQPHSNSRPQSHACHHCSCSQHCQSRSRSRSCRSRSSSRRPRSHRSPTGRQGQSPGPSPPLRRHRHTMHSHQCPSRPVTHSCSHSKNRKNLEGKVIKRKQVKRSKQVYKRKRQSSGRKYN

Gene
TNP2
Protein
Nuclear transition protein 2
Organism
Canis lupus familiaris
Length
129 amino acids
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Similarity
Belongs to the nuclear transition protein 2 family.
Mass
14.567 kDa
Sequence
MDTKTQSLPITHTQPHSNSRPQGHTCSQCTCSSHCQTCSQSCSQSRSSSQSPTGHHSSSGHQSQSPHPTLPPRHQKHTRHSHHCPPRPTTHSCSYPKNRKNFEGKVNKRKVVKRSQQVYKTKRRNSGRK

Gene
Tnp2
Protein
Nuclear transition protein 2
Organism
Mus musculus
Length
117 amino acids
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:15163613, PubMed:15189834, PubMed:15083521, PubMed:28366643). In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). The histone H2AFB1-HIST1H2BA/TH2B dimer is required for loading of TNP2 onto chromatin (PubMed:28366643).
Similarity
Belongs to the nuclear transition protein 2 family.
Mass
13.117 kDa
Sequence
MDTKMQSLPTTHPHPHSSSRPQSHTSNQCNQCTCSHHCRSCSQAGHAGSSSSPSPGPPMKHPKPSVHSRHSPARPSHRGSCPKNRKTFEGKVSKRKAVRRRKRTHRAKRRSSGRRYK

Gene
Tnp2
Protein
Nuclear transition protein 2
Organism
Rattus norvegicus
Length
114 amino acids
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:11772016). In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (By similarity).
Similarity
Belongs to the nuclear transition protein 2 family.
Mass
12.848 kDa
Sequence
MDTKMQSLPTTHPHPHSSSRPQSHTNNQCACSHHCRSCSQAGHPSSSSSPSPGPPTKHPKTPMHSRYSPSRPSHRGSCPKNRKTLEGKVSKRKAVRRRKRTHRAKRRSSGRRYK