tnfaip1

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

319 amino acids

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Belongs to the BACURD family.

36.488 kDa

MSGDTCLTAVCPASGAKPKTYSFKGGCLGNKYIRLNVGGCLYYTTVQVLTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGSILNYLRDDTIALPKSRHEIKELMAEAKYYLIQGLVDKCQTALQDTNDTYEAVCNIPIITSPKEEEKLIESSAKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRIRSQASHSEDDDGFELRDRVRRIHVKRYSTYDDRQLGHQSAYRD

tnfaip1

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

319 amino acids

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Belongs to the BACURD family.

36.48 kDa

MSGDTCLTAVCPASGAKPKTYSFKGGCLGNKYIRLNVGGCLYYTTVQVLTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGSILNYLRDDTITLPKSRHEVKELMAEAKYYLIQGLVDKCQAALQDKNDTYEAVCNIPIITSPKEEEKLIESSAKPVVKLLYNRSNNKYSYTSNSDDNLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRTRSQASHSEDDEGFELRDRVRRIHVKRYSTYDDRQLGHQSAYRD

TNFAIP1

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

316 amino acids

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

Belongs to the BACURD family.

36.204 kDa

MSGDTCLCPASGAKPKLSGFKGGGLGNKYVQLNVGGSLYYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQNRQEIKELMAEAKYYLIQGLVNMCQSALQDKKDSYQPVCNIPIITSLKEEERLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASPSEDEETFELRDRVRRIHVKRYSTYDDRQLGHQSTHRD

Tnfaip1

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

316 amino acids

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity (By similarity).

Belongs to the BACURD family.

36.134 kDa

MSGDTCLCPASGAKPKISGFKGGGLGNKYVQLNVGGSLYYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQSRQEIQELMAEAKYYLIQGLVSTCQTALQDKKDSYQPVCNIPIITSLREEDRLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASPSEDEDTFELRDRVRRIHVKRYSTYDDRQLGHQSTHRD

TNFAIP1

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

316 amino acids

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity (By similarity).

Belongs to the BACURD family.

36.151 kDa

MSGDTCLCPASGAKPKLSGFKGGGLGNKYVQLNVGGSLYYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQNRQEIKELMAEAKYYLIQGLVNMCQSALQDKKDSYQPVCNIPIITSLKEEERLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSCSQASPSEDEETFELRDRVRRIHVKRYSTYDDRQLGHQSTHRD

Tnfaip1

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

316 amino acids

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis (By similarity). May enhance the PCNA-dependent DNA polymerase delta activity.

Belongs to the BACURD family.

36.046 kDa

MSGDTCLCPASGAKPKISGFKGGGLGNKYVQLNVGGSLHYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVTLPQSRQEIQELMAEAKYYLIQGLVSLCQAALQDKKDSYQPVCNIPIITSLREEDRLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASPSEDEDTFELRDRVRRIHVKRYSTYDDRQLGHQSAHRD

TNFAIP1

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

314 amino acids

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity).

Belongs to the BACURD family.

36.032 kDa

MSGDTCLTTTLCPAVGPKPKTCSFKVGSLGNKYVRLNVGGSLYYTTVQVLTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTIALPKHRQEIKELMAEAKYYLIQGLVDMCQAALQDKKDLYEPVCNIPIITSPKEEERLIESSMKPVVKLLYNRSNNKYSYTSNSDDNLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASHSEDDDGFELRDRVRRIHVKRYSTYDDRQLGH