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TIM21

Gene
TIM21
Protein
Mitochondrial import inner membrane translocase subunit TIM21
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
277 amino acids
Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Similarity
Belongs to the TIM21 family.
Mass
31.037 kDa
Sequence
MKSISTLGICLRASQDLAKTRPISLLSTRSFANLTQGTSTYHSLSIRSIRHNRLEARYTNILNRNILPYKNYSTGTAPPPPPPPPPPHDKNAKGKFLFNRIGRAFTFSLSSVIVLGATCISVLVVYLILSELFLPSGDTRTFNKAVRMLESNELAHEALGFKKGQRVKAHGEQHADKWARNRPAQSVRTRGADGKDYLFMKFQVESPSGKYGTVTLEQVDRTFWSSEFLYIALDMPGNKRIYIKEPKFQSKKYVPKVGSLASNDGFLGLKWGPKKDD

Gene
TIM21
Protein
Mitochondrial import inner membrane translocase subunit TIM21
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
269 amino acids
Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Similarity
Belongs to the TIM21 family.
Mass
29.92 kDa
Sequence
MLTRPLLALSRPMALGALRPAVLVRTLTTAGPTTTVRSTPIITPSHLSTLSRSTPFVSNCTLSLLKRSFHVSSDARSAAKAEGKPKVSAYEKANMRLAKIGVFFQLSWYLGIILAALGLFGLVWYYLIMELVMPSGDVRIFNRAFKEIEKNEDVMRVLGGQLSSMGEGGGGRWGRNQPPVSKRGIDKYGREHIWMNFYVSGDINEGRAKLELVQNTDSKLSSERFVYRYFVVDIPGHKRIYIAGNAAEKMEKKKSTGWLGVNWGKSDDE

Gene
TIM21
Protein
Probable mitochondrial import inner membrane translocase subunit TIM21
Organism
Arabidopsis thaliana
Length
269 amino acids
Function
May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Similarity
Belongs to the TIM21 family.
Mass
30.047 kDa
Sequence
MMMMNLLRRSAIAIGRQSKSKLASFSSATQPCSGIPKSSKRVFSNSFLSKDSTGANGLLFRFRNPQASICTEARPKNINSSYFTRSFASRTSKEPGNQQNKAKKEVTTVEDPFDSPTYHIPEKPVTFTEGASYSLVILAGLGVAGAAGYGVFKELIFQPKEYKVFDKALKRIQDDGQVRVRIGSPIKGYGQETRNRAARQRIPNRVFTDEDGVEHVEVNFYIRGPQGAGKVYTEMFKDKAEKEWKYTYLIVEILTPSPAKLMLESYLPA

Gene
TIM21
Protein
Mitochondrial import inner membrane translocase subunit TIM21
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
268 amino acids
Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Similarity
Belongs to the TIM21 family.
Mass
30.085 kDa
Sequence
MHMIQRVSSIGLRTLRSSNIGSIRSLIVLPILSIKPTYIRQTQAQINLKPQALLLNLLLHHHHHHHHYYSTKTAPPPPPPPQPPQDKNAKGKKILNRINRAFTFSLSTLLVVGAAGISVLVVSLILSELFLPSGDTRTFNKAVKLIEKNEQAQKALNFQSGQRLKAYGIVSADKWVRNRPVQSVKTKRKDGKDHLIMKFQVESDNGKYGVVSLEQIDNSMWNTEFEYISLDVPGFKRIYIIEPPKNQLIPKIGGGSGFLGLNWGPKKD

Gene
tim21
Protein
Mitochondrial import inner membrane translocase subunit tim21
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
251 amino acids
Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Similarity
Belongs to the TIM21 family.
Mass
27.798 kDa
Sequence
MMKMLTGTSAGVRLLLSPAVVRQQATITTAASRALPPTAASVILVSSRRQYATTQESSKRRSVTPFNDDGHVPWTRLSTGEKAGRAVQQTFNFGLVILGVVLTGGIAYLLFTDVFSPESKTAYFNRAVDRIRADPRCVALLSPGDPKKIAAHGEETHNKWRRARPIAATVEKDNRGVEHLKMHFHVEGPRGSGVVGLHLTKQPGHWEHEYQTFYVDVRGHQRIYLENKEAEVAAAKKGGNKEFKFLGVKWN

Gene
TIM21
Protein
Mitochondrial import inner membrane translocase subunit TIM21
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
239 amino acids
Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix. In the complex, it acts as an antagonist of TIM50 by reducing preprotein accumulation at the TOM23 complex and promotes dissociation of the PAM complex from the TIM23 complex.
Similarity
Belongs to the TIM21 family.
Mass
27.206 kDa
Sequence
MSSSLPRSLLRLGHRKPLFPRYNTFVNSSVITHTSLLRTRLYSNGTGATSGKKDDKTRNKPKPLWPQVKSASTFTFSGILVIGAVGISAIVIYLILSELFSPSGDTQLFNRAVSMVEKNKDIRSLLQCDDGITGKERLKAYGELITNDKWTRNRPIVSTKKLDKEGRTHHYMRFHVESKKKIALVHLEAKESKQNYQPDFINMYVDVPGEKRYYLIKPKLHPVSNSKGFLGIRWGPRKD

Gene
tim21
Protein
Mitochondrial import inner membrane translocase subunit tim21
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
237 amino acids
Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Similarity
Belongs to the TIM21 family.
Mass
26.788 kDa
Sequence
MMSPHLLPSTSIPKASAALLLRPAFPRMTTLTRFYATQSDLGGGSGSKATPRRRNVTVLSDDGRYEWGELSGREKVARATQQSLNFLVIVAGAVLTGGVFYLLYTEVFSPNSRTWQFEKAVQRIKDDPRCTDLLGDRREIKAYGESTGSRWERNRPIATSMFKDRQGREHMKMHFHVEGPLNSGIVIVHMMKPLDKDEWEYLLLALDVKGHSRVILEQAQEKPGVAKALKIFGIQWR

Gene
TIM21
Protein
Mitochondrial import inner membrane translocase subunit TIM21
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
234 amino acids
Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Similarity
Belongs to the TIM21 family.
Mass
26.566 kDa
Sequence
MFCQFISRPAQSLSGKFSSKTLCLPLIASPVRIKHTVQGYSTFNAQQNAGNKQQKKKIPLWPRIRAFTTFTFSGILVIGATGLAGVVIYLIGAELFSPSGDTQIFNRAVSKVENDEVARRLLKCNDTETSTERLKAYGEILTDDRWTRNRPISSTRRIDKEGKEHYLMRFHVESKQKMGIVHVEAKESDVNYQPDFVSMYLDIPGEKRHYLIKPKLSIVKPKGFLGVNWGPKRD

Gene
TIM21
Protein
Mitochondrial import inner membrane translocase subunit TIM21
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
234 amino acids
Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Similarity
Belongs to the TIM21 family.
Mass
25.929 kDa
Sequence
MLAFGSICGRLRAPAGAGLRVNVGKMPGRAWQVANGQPYSTFYAPPEQAGNRQKERRVTAWKKVRAAATFSASGMLVLGAAGVAGIVLYLILSELFSPSGDTQIFNRAVSTVEGDAVARSLLQCEDGVHRSERLKAYGDSVGDDRWTRNRPISSTRRLDASGREHYYMRFHVETGRRRGVVSLEAQQSDDSYQPEFVRMYLDVPGEKRHYLIRPEPSVAKPKGFLGLNWGPRKD

Gene
TIM21
Protein
Mitochondrial import inner membrane translocase subunit TIM21
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
229 amino acids
Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Similarity
Belongs to the TIM21 family.
Mass
26.006 kDa
Sequence
MNPTTNLLVTRSTAFRGVPTTLRPFLASRYYATQQGLGATPRGPKRRAVTPFNDNGHVPWKQLSVAEKAARATQQSFNFGMILVGLMLTGGVGYFLWTDVFSPDSKISNFNRAVDKIRSDPRIIDVMGDSKKIAAHGDETFNKWRRARPVASSETTDARGDQHIMMHFYVEGPKNNGVARLHMIKYRGHSDFEYKYLFVDVKDHERIYLEHEDSSSKNGKKFSLFGVKW

Gene
tim21
Protein
Mitochondrial import inner membrane translocase subunit tim21
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
223 amino acids
Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Similarity
Belongs to the TIM21 family.
Mass
25.568 kDa
Sequence
MIRTIQRQSATRFSSALVQRRLYSLASDSLNKQRKPQEEGRLARIFKDPSNKAWKDLTAPQKAYRTSANIGNFSIVIFGGGVFGLIIYALVTSIWKGEAHYGDEAFELLKANEECRYVFGDHMKALGEATHPLRRTHGILTSRVWDHHGVEHLVLQFHLIGNERKGHVFGRLVNVQGDYKWEYLFVDVANYGKIIIFDHTNSVRQQHKNFGLWGSLKNITWGN

Gene
TIM21
Protein
Mitochondrial import inner membrane translocase subunit TIM21
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
215 amino acids
Function
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
Similarity
Belongs to the TIM21 family.
Mass
24.671 kDa
Sequence
MVLRSRPLASIPRVQFYSSKGKSKGKTSGEKKPEHKKIPVWHKLKALTSFTASSLLVVGGVGVSGVVLYLILSELFSPSGDTMLFNRAVTLVEDNEEVRKLLQCNDSSFKKERLKAYGELVTNDRWTRNRPIVSTQKIDKYGKCHHFMRFHLESKKKLGLVHVEAVDSEQNYKPNFVSMYIDIPGEKRFYIIRPKLRQVVRPKSIFGFPWGSRKE