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TFB4

Gene
TFB4
Protein
General transcription and DNA repair factor IIH subunit TFB4
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
387 amino acids
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Similarity
Belongs to the TFB4 family.
Mass
41.795 kDa
Sequence
MDAIADSVFTDIGSSDSPSDDPSLLTVVLDVTPQSWYKIRNQITIQEVAKSLLVFLNAHLSLNNSNQVAFIASTPQGSKFLYPNPEKNYDEVSSKKNGEGSNLNKADSTSSLVGDGMYRQFRIVDEAVLEKLNEIFADISQNVDKSRSNSTLSGALSLALTYTNRMLNLDSSISTTTASAINTTTNANSNKTSSSGTTSNSMSTGGTNTTSLTSMRSRILIVSSNDDNDIKYIPIMNTTFAAQKMKVPIDVAKLGERDSSYLQQASDATNGVYLHIANPEGLIQTLSTAFFIEPSIRSLIILPTNSNVNYRASCFITGKSVNLGFVCSVCLCIMSIIPKEGKCPTCGSKFDEKILAQLRRGVVIPVKKKRKLDSNGNGQSDNVTPEI

Gene
TFB4
Protein
General transcription and DNA repair factor IIH subunit TFB4
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
341 amino acids
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Similarity
Belongs to the TFB4 family.
Mass
37.863 kDa
Sequence
MDAIADSTFQINKSKVQLVEETPSLLTLVIDTNPKLWAEFDREVGKKGQLMQVLKSTIVFLNAHLSFNNSNQVSVIAACSRGIKYLYPQADDKEGSTKKKKSEDRSIINRNMYRGFRNVDEAVVEELYRVFQQESKQLEDGVPQPFRSTLSGAMSAGLTYINRITHETEGVSLKSRLLVITCGSSASKDEVFQYIPIMNCIFSATKMKCPIDVVKVGGVKESTFLQQATDATNGNYLHVANTDGLIQYLSTAMFIDPSLRQWVVKPNQSSVDFRTSCYLTGKVVAIGFVCSVCLCVLSIIPPGNKCPACDSEFDEKVVAKLSRKPVITGTLRKKKKKKVTK

Gene
TFB4
Protein
General transcription and DNA repair factor IIH subunit TFB4
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
340 amino acids
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Similarity
Belongs to the TFB4 family.
Mass
37.795 kDa
Sequence
MNAIDGTSRQLKDTEDQTLDDTPSLLSIIIDAHVPSWEEIKSQISISEAVASILVFINAHLALHNSNSVNVIGYNASGARILYPPKSGVESTRSKEREERSESVSDGEQAPSKKDHSMYRQFKTVDEVVQTELWNMLNHTNYVEEEKQHNSAISGALSLALGFINKHVFVDESRMRARILLLTVGHKNETIQYIPTMNCIFAAQKLKIPVDVCKLGPGSDQVFLQQACDSTHGIYMDISEKNSKTPKGLVQYLLSGFISDPSLRPHIVLPTQSNVDFRAACFLTKQVVDIGYVCSVCLCIMSQIPSNRRCPTCDTTYSEKTLAGLGRKPLKKKKKKVVKP

Gene
TFB4
Protein
General transcription and DNA repair factor IIH subunit TFB4
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
338 amino acids
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Similarity
Belongs to the TFB4 family.
Mass
37.457 kDa
Sequence
MDAISDPTFKHARSRKQVTEESPSLLTVIIEIAPKLWTTFDEEGNEKGSIIKVLEALIVFLNAHLAFNSANKVAVIAAYSQGIKYLYPESTSALKASESENKTRSDLKIINSDMYRRFRNVDETLVEEIYKLFELEKKQIEQNSQRSTLAGAMSAGLTYVNRISKESVTTSLKSRLLVLTCGSGSSKDEIFQYIPIMNCIFSATKMKCPIDVVKIGGSKESTFLQQTTDATNGVYLHVESTEGLIQYLATAMFIDPSLRPIIVKPNHGSVDFRTSCYLTGRVVAVGFICSVCLCVLSIIPPGNKCPACDSQFDEHVIAKLKRKPVVPRLKAKKKVTKP

Gene
TFB4
Protein
General transcription and DNA repair factor IIH subunit TFB4
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
337 amino acids
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Similarity
Belongs to the TFB4 family.
Mass
36.843 kDa
Sequence
MDAIADTVFQGTKSKTQEIEDTPSLLTVVVDTSIHSWVQLTKQQSGSGSEGSSGEKQLIEALKSIVVFLNAHLAFNSGNQVCLIAAHSEGMKYLYPSADSKPSMSMVSSDMYRGFRNVDEIVVEQWYRLFKEELEGQESKVSMKSSLSGAMSSALTYVNRILKENENTSLRSRLLVITCGTSQGKDEIFQYIPIMNCIFSATKMKCSIDVVKIGGGIESTFLQQATDATSGVYLHVENTRGLIQYLSTAMFIDPSLRNVIIKPNQGSVDFRTSCFLTGKVVAVGFVCSVCLCVLSVIPPGQKCPACDSPFDSKIIARLRRKPVLSNGVPKKKNVSNK

Gene
TFB4
Protein
General transcription and DNA repair factor IIH subunit TFB4
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
335 amino acids
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Similarity
Belongs to the TFB4 family.
Mass
37.342 kDa
Sequence
MDAIADPNFQQTKLRSTATEDIPSLLTVVLDISPRLWAEFDHRSGEKQSVTTVLKSLIVFLNSHLAFNSANQVAVIAAFSQGIQYLYPRSSDTSEQNAGNSKDLSIISSHMYRRFRNVDETLIEEFYKLYQREESLIDKPVQKSTLSGAMAAALTYTNRLTKEFESISLRSRLLVITCGSSREKDEIFQYIPIMNCIFSATKLKCPIDVIKIGGNKQSTFLQQTTDATNGVYIHLESTNGIIQYLSTAMSIDPSLRQIIVRPTQGSVDFRTSCYLTGKVVAIGYICSVCLCVLSIIPPGNKCPACDSQFDERVIAKLKKKPVVPKSTLKKVKKKV

Gene
TFB4
Protein
General transcription and DNA repair factor IIH subunit TFB4
Organism
Arabidopsis thaliana
Length
301 amino acids
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Similarity
Belongs to the TFB4 family.
Mass
33.068 kDa
Sequence
MPAIASKQYSDDVSLLVLLLDTNPLFWSTTSITFSQFLSHVLAFLNAVLGLNQLNQVVVIATGYSSCDYIYDSSLTSNHGNFESNGTGMPAIFGSLLKKLEEFVTKDEELSKEEVSEDRIPSCLLSGSLSMALCYIQRVFRSGHLHPQPRILCLQGSPDGPEQYVAVMNSIFSAQRLMVPIDSCYIGVQNSAFLQQASYITGGVHHTPKQLDGLFQYLTTIFATDLHSRGFVQLPKPIGVDFRASCFCHKKTIDMGYICSVCLSIFCEHHKKCSTCGSVFGQSKLDDASSASDKKRKAPST

Gene
tfb4
Protein
General transcription and DNA repair factor IIH subunit tfb4
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
297 amino acids
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
Similarity
Belongs to the TFB4 family.
Mass
33.277 kDa
Sequence
MDEFQTLKQNASWDISEDANDTPSLLVVILDANPASWYSLSKKVPVSKVLADITVFLNAHLAFHHDNRVAVLASHSDKVEYLYPSIAPEQKVAEVDPTKEANTYRKFREVDDLVLSGMKRLMSSTDKVSRKTMISGALSRALAYINQVQNKNTLRSRILIFSLTGDVALQYIPTMNCIFCAQKKNIPINVCNIEGGTLFLEQAADATGGIYLKVDNPKGLLQYLMMSLFPDQNLRKHLNTPNQANVDFRATCFCHKKVLDIGFVCSVCLSIFCEPRVHCSTCHTKFTVEPMSKKLHT