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TF22

Gene
TF22
Protein
Trichosetin biosynthesis cluster transcription factor TF22
Organism
Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)
Length
454 amino acids
Function
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of trichosetin, a trans-fused decalin-containing tetramic acid with antimicrobial activity (PubMed:28379186). Directly activates expression of only the three biosynthetic genes PKS-NRPS1, DA and ER, while TF23 and MFS-T are induced by the final product trichosetin and not by TF22 (PubMed:28379186).
Mass
49.562 kDa
Sequence
MSTRNSQSIRSSCDRCRSHKLKCTVSPEDSRSGPHKCTRCIRAQVTCVFGPRSQSKRTPNGKNKPEKPKPELEPPQKTSPPVCSSSLAGMDLGSPGAWTPWIDDLASQETEEPLPIDVNTAGDGSGPSDGDFWADLGMTQELNMLELAPTNTYQAQYLASFDYVAPPVAEVGHLMDISEPSEHTPPHAIVQLSTLVTKIHETSKALEESPWSNVPDAKQLQNYPIGRVLSLSQDFCSILGCIWGKVSISSDGQSSGSGSSPTPSADMLDYAEVLSSIKITQDPTASSSMAASVDMPTALLVLSCYTSLIKLYSLVFAHFENHLSHLPEIPSPYPSQAALASHRWGLQLGELPSADETCTKICTAVQVLLDAFQSVEDVFGLPRSFSAVRQRTCDMEGMDFSAELGRTSLWTDYMVHFVVRSNAIRADTEECEEMRELSTKVRSLKALIREKMNL