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TEN1

Gene
Ten1
Protein
CST complex subunit TEN1
Organism
Mus musculus
Length
161 amino acids
Function
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (By similarity).
Similarity
Belongs to the TEN1 family.
Mass
18.066 kDa
Sequence
MLPKPGVYYFPWEVSDGHVPEGSTLRTFGRLYLYDMARSLMTLAAPQKPDQCQLLVCTNLVEPFEAHVNFLYMVLGDLERMEGGAFVVRARLLTCVEGMDLSLLEKAILEQRRHLQKRQQPIGDASTLQTPTPAPQSIPSDSLSLEPENRGQQVPLPQTLD

Gene
TEN1
Protein
Telomere length regulation protein TEN1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
160 amino acids
Function
Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13.
Mass
18.605 kDa
Sequence
MSQLVLDLKCLKDKIATNYDIHNNVYGGNGMEPNIIHPSKRFRIVVRLVDFLFCKSDEEFIKGFFCQMIVRNLHCLNSTNGAEEMRLYMSERLFSAHKDDLRLINGQVLDVRIGVWYGIHQSPPIFEIIDFKILSRNDVRDFCEFVKSPLGEKFLNISNS

Gene
TEN1
Protein
CST complex subunit TEN1
Organism
Arabidopsis thaliana
Length
127 amino acids
Function
Required for the maintenance of meristems and stem cells through the reduction of DNA damage (PubMed:21781195). Promotes telomere integrity by maintaining telomere length and proper architecture of the chromosome terminus (PubMed:23572541). Negatively regulates telomerase repeat addition processivity (PubMed:23572541). Hampers contacts between enzymatically active telomerase and CST complex (PubMed:25329641).
Similarity
Belongs to the TEN1 family.
Mass
14.378 kDa
Sequence
MAKSQIEPGVPITLQELYPSSLFYKEGVSLRVTAMLRGYSVETAIGVIEDGGRSLKINTQNIRDVSFRVGSIYQFIGELHIEQPNNEAILQARTGRNVDGIDMNLYRKTIELLRQFLKEEDNSNMVE

Gene
TEN1
Protein
CST complex subunit TEN1
Organism
Homo sapiens
Length
123 amino acids
Function
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha (PubMed:22763445). The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins (PubMed:25483097).
Similarity
Belongs to the TEN1 family.
Mass
13.856 kDa
Sequence
MMLPKPGTYYLPWEVSAGQVPDGSTLRTFGRLCLYDMIQSRVTLMAQHGSDQHQVLVCTKLVEPFHAQVGSLYIVLGELQHQQDRGSVVKARVLTCVEGMNLPLLEQAIREQRLYKQERGGSQ

Gene
ten1
Protein
Protein ten1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
102 amino acids
Function
Required for telomere maintenance.
Mass
11.533 kDa
Sequence
MDSAKLIFINQINDCKDGQKLRFLGCVQSYKNGILRLIDGSSSVTCDVTVVLPDVSIQKHEWLNIVGRKRQDGIVDVLLIRSAVGINLPRYRQMVSERQKCD