tbx6

T-box transcription factor TBX6

874 amino acids

T-box transcription factor involved in the development of paraxial mesoderm.

94.964 kDa

MLGVEMYPGLALGPQRLSDCYYRDRDVPLYPSTCEMAARALPPALLKPHANTDSPATPQDSVRMELENAGLWKQFSTVGTEMIVTKKGRRMFPQLRVKLSGLNPSLRYILLLDIVPVDSSRYRFQDNSWQVVGGAEARLPDRVFIHPDSPATGEHWQNRTISFHRAKLTNNTLDAQGYIILHSLHRYQPRVHVIEARDVLMWGRTQHSFTFPETQFITVTAYQNNKITELKINSNPFAKGFRENGMNCKKQREARLKRKITSSQEECLDIESCDPCDSTELLPQSVDLPSSALTIMNTALPITDSGFHTEVSSHPDQTDSDQTLVLEQAFLTSEMPSSMESQQQTTSETNVNNALMDETGQMMDLSGYTSSFPTPQLSSHTSVPQSSSMYSVVSSTQSSDLELPQASSISSPHSMPAYSSIPSAEYPGVNSSTAMPASTTSLSDSYPSISHSTSSHLLQSSSYHSLLPTDQSQDNLSPHTPTNPPFQSIPACQGTRLTIDSGQNQVDDGGLSSANATTPAVPNPTQTAFPFPPVQPNNDPDPTSPSCQSLPQSALPYQQVSQCNQIPTPSDPNTTPTAFPFPPSEQSTPNSIMVSSNPNTTAFPFPPVQQQLNLSTSGPSSFPVSQSSGLNAIPNPVHPTTGSFSFPSTSAIHQGPMQSVPNTLHPSTAYTFPSSLPKHTGPLPNPAPTSYPFPTPIPPGPHPLQSLTLPSSCSIPNTSQIQSTFPQSYHNPSFSHIPPQMANHSQITSQSFPPLQTSSAPQLLSQSSTHPQCPPPSNAYPAVAPTEIGTFPQLNSAAPYLPDVVLHPSILPSLDPSLSSSAPPSLYNPFPSYSLRLCQDPRSSLHLPLRHIYRQPQHAHGQGSYFDLGGRTVF

tbx6

T-box transcription factor TBX6

517 amino acids

Transcriptional activator. Plays a role in ventral mesoderm specification and acts together with nog during muscle differentiation. Mediates posterior pattern formation of the embryo, including specification of posterior mesoderm, via activation of the Wnt and Fgf signaling pathways (By similarity).

57.579 kDa

MYHSELFQQYGTSYGMRPPHALAPTYPTAGGHHEAYRYPELDVPGQRFDGLFPALDPSQRILGAPPLTPLSLPPGPALGFGQLQPPCETPQLPGNVKMNLENKELWKQFHSIGTEMIITKSGRRMFPQCKVSVTGLEPDGKYLLLADIVPIDNSRYKWQEDRWEPSGRAEPRLPERVYIHPDSPAPGSHWMKQPISFHKIKLTNNTLDQMGHIILHSMHKYQPRFHIVRAQDVFSRRWGGCSSFTFPETLFLTVTAYQNEKITQLKIQTNPFAKGFREDGMKSKRDRSTRVKRKVIEPEEEEEEFQPEGECKRPLYTGPCDSTLSEELDIGRGLGIPLPSPDCSFHPITPPSRTPPSTQTPNPSLTANQEQGAALEMSSQTPETFLQAAGQSYPEQPPVRGGSLYPCPTDGHGAQNQRHPLSVQRLPQAFQGLQESLGNSPGEYKIYGGDVGCGGDFAPPSCAVAPSVRPSEERLPRGYSMNSELRFPHFLPNGGSKIGLQFSGAQLQRLYNGGGWM

tbx6

T-box transcription factor TBX6

506 amino acids

Transcriptional activator. Plays a role in ventral mesoderm specification and acts together with nog during muscle differentiation. Mediates posterior pattern formation of the embryo, including specification of posterior mesoderm, via activation of the Wnt and Fgf signaling pathways.

56.559 kDa

MYHSELFQQYGTSYTMRPPHALAPTYPSAGGHHDSYRYSELDVPSQRFDGLFPALEPSQRILGAPPLTPLSLPPGPALGFGQVQPPCETPQLPGNVKMKLENKELWKQFHSIGTEMIITKSGRRMFPQCKVSVSGLEADGKYLLLADLLPVDNSRYKWQEDHWEASGRAEPRLPERVYIHPDSPAPGSHWMKQPISFHKIKLTNNTLDQMGHIILHSMHKYQPRFHIVRAQDVFSRRWGGCSSFTFPETLFLTVTAYQNEKITQLKIQTNPFAKGFREDGMKSKRDRSIRGKRKVISVEQEQEEEEQFQPEGECKRPPLYSGPCDSTLSEELDIGRSLGIPSPNCSFHPITPPTQTPPSTETPNPSLPANQEQGAPLQMSSQTPGTFLQTYPEPPRGASSLYSCSPTDAAQNQTLRPSAQRLPPGYQESPHISHSQGELKIYGTEMGPPGNFNPPSCAVTPSVRLSDEPMGRGFSMNFPHFLPNNKIGLQISGAQLQRMYNGGGWM

TBX6

T-box transcription factor TBX6

457 amino acids

T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to also play an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity).

49.686 kDa

MYHPRELYPSLGTGYRLGPPQPGADSSFPPALAEGYRYPDLDTPKLDCFLSGIEAAPRTLAAPPPLPPLPPALGTEPSPPSAPEGLHSLPGVSLSLENRELWKEFNSVGTEMIITKAGRRMFPACRVSVTGLDPEARYLFLLDVVPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGVASFRFPETTFISVTAYQNPRITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPAATAGYGSGDAPGGPCDSTLGGDVRESDPEQAPVPGLPLPQLLPAVAPVLRPTCCTLPLSTGPPVTFQPGIPASRRLQTLPSALLSRLPGAAARASRLRIPSSSTLSILCLALPPRGPLPTALPWAWGLPRCGLQTNVLSLCSLPPGLLPPHFHYPFPHTK

TBX6

T-box transcription factor TBX6

436 amino acids

T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity).

46.96 kDa

MYHPRELYPSLGAGYRLGPAQPGADSSFPPALAEGYRYPELDTPKLDCFLSGMEAAPRTLAAHPPLPLLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPACRVSVTGLDPEARYLFLLDVIPVDGARYRWQGRCWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPETTFISVTAYQNPRITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPAATEACGSGDTPGGPCDSTLGGDIRESDPEQAPAPGEATAAPAPLCGGPSAEAYLLHPAAFHGAPSHLPTRSPSFPEAPDSGRSAPYSAAFLELPHGSGGSGYPAAPPAVPFAPHFLQGGPFPLPYTAPGGYLDVGSKPMY

TBX6

T-box transcription factor TBX6

436 amino acids

T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity).

47.045 kDa

MYHPRELYPSLGAGYRLGPAQPGADSSFPPALAEGYRYPELDTPKLDCFLSGMEAAPRTLAAHPPLPLLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPACRVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPETTFISVTAYQNPQITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPAATEAYGSGDTPGGPCDSTLGGDIRESDPEQAPAPGEATAAPAPLCGGPSAEAYLLHPAAFHGAPSHLPTRSPSFPEAPDSGRSAPYSAAFLELPHGSGGSGYPAAPPAVPFAPHFLQGGPFPLPYTAPGGYLDVGSKPMY

Tbx6

T-box transcription factor TBX6

436 amino acids

T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia.

47.006 kDa

MYHPRELYPSLGTGYRLGHPQPGADSTFPPALTEGYRYPDLDTSKLDCFLSGIEAAPHTLAAAAPLPLLPSALGPETAPPPPEALHSLPGVSLSLENQELWKEFSAVGTEMIITKAGRRMFPACRVSVTGLDPEARYLFLLDVVPVDGARYRWQGQHWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRATQLCSQHWGGVASFRFPETTFISVTAYQNPRITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPVATEACGSGDTPGGPCDSTLGGDIRDSDPEQAPTPQEAASASAPPCGGPSAEAYLLHPAAFHGAPSHLPARTPSFAEAPDPGRPAPYSAAFLDLQPGPGGSAYQAAPSVPSFAPHFIQGGPFPLPYPGPGGYLDMGSKPMY

Tbx6

T-box transcription factor TBX6

436 amino acids

T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to also play an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity).

47.216 kDa

MYHPRELYPSLGTGYRLGHPQPGADSTFPPALTEGYRYPDLDTSKLDCFLSGIEAAPHTLAAPPPLPLLPSALGPETAPPPPEALHSLPGVSLSLENQELWKEFSAVGTEMIITKAGRRMFPACRVSVTGLDPEARYLFLLDVVPVDGARYRWQGQHWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRATQLCSQHWGGVASFRFPETTFISVTAYQNPRITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPVATEACGSGDTPGGPCDSTLGGDIRDSDPEPAPTPQEAASASAPPCGGPSAEAYLLHPAAFHGAPSHLPARTPSFPEAPDPGRPAPYSAAFLELQPGPGSSAYQTTPSVTPFAPHFIQGAPFPLPYPGPGGYLDMGSKQMY