Protein
TATA box-binding protein-associated factor RNA polymerase I subunit A
Organism
Rattus norvegicus
Function
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits (By similarity).
Sequence
MMSDFSEELTKLAGAEDNPETSEFSKTRMHFPWLQKHIEAVVTGGKKRKDFAQTTSACLSFLQEALLKHQWCRAAEYMHSYLQTLEDSDTYRKQAAPEIIWKLGSEILFYHPKSNVETFSSFADRMKNIGVLNYLKISLQHALYLLHHGMLEDANRNLSEAETWRYGEKSASQEVLIKLVQAYKGLLQHYSWSKKKMELSELDEDDYAYTAKSRNMLSQSSKTSTNICTLIKTPGVWDPFVKSYVEMLEFYGDQDGARELLTNYAYDEKFPSNPNAHVYLYEFLKREKAPRAKLISVLKILHEIVPSHSLMLEFHTLLRKSETEEHRKLGLAVLFEVLDFSGCTKNITAWKYLAKYLKQTLMESHREWVEEEWKSRRNWWPAFHFSFFWAKSDWKADAELACEKAFVAGILLGKGCRYFRYILKQDHETLKKKIKRMKKSVKKYTIVNPGVHT