Function
Required for underreplication of DNA, which is found in many late replicating euchromatic regions of salivary gland polytene chromosomes (PubMed:11901119, PubMed:12456726, PubMed:30277458). Functions by promoting the localization and retention of Rif1 to active DNA replication forks where Rif1 inhibits replication fork progression (PubMed:30277458). Controls chromatin organization in polytene chromosomes (PubMed:12456726).
Sequence
MYHFVSEQTPEVRLTDEALVTSHVTQYLKSFQLDAVRFVYDRLAKREFCILNDESGLGKVATVAALLSALPPAKKTLVVLQNDEQLLTGWRFHLDTLTDLQVYIIQGVQDTTDSPHSVYLAKWSQLRSIGDLSRLKFDYIMVDNRGHSLNNSFCTSMLLKQFEGRVNVLISSVDVTSDVRLLYNVLRLGGRLEHQYKSFASFDRKFHLPDPKEVFSKRIDLEEYYKQRGFLSEYIKDFRLRRFRHQFDKSLPLVAPEQYKHNLNLWLASKNSQSTISGSDVCSTIASIDNNPAQQNKTGLFEETDRLSEHSVDDVAMSPLIFEYSESDDEPLTVEPDADQNPVLVVSSDDCEIVTPPSTPQNRTPSLNESPRTKSKKKFSKKTSPRKKADLTDSEEDDEATDNMPPRKRTRAATVHLTPKTRRLNVRILRVSLDTLSTPPPSRTTTAIVTPKTEPTARRKNLKKRTVSPVDVGRPATRGMQRLTRSAETKINSKYLKHRSLDDVKRSFPRRVKLEGNQTPRSSKQIVKQEPKSKVGQEKKQKTVDVPAQGTAKRKPGRPRKCQTKTEDLGKTKTKPNSKHLPPTPQVLSGSSLSSEYMQCAQRIPDNLDAIESPAFRVPFTPQQTPMLLTLPSTHNLLNDSEVVSIPLYKDPVETVVINSSHDECSPQDPSQSRRTKALKRKRKPVTSVNSSFGGGLGLPPAKRSANKSPDLFSISSEHSQIPLAQPRPSSPFEGFKIFGSEVKQFQQQLAKVNISVPKKKRDRSCLDILEQMFEPRQQQSAKTSPKVLPTLPLTQKDDAESTITQRRRTLLEDDFFEITNNGQFGSRMRLNSSGEVSPVQPDQQSVRPSQANKITNYLIGSGITQERTQPSNGNRNSILASLRKSPKSPKQGAKSTQATKLTRWFGSVFGGGASQTSSVESVSAPSTPVNSSTSAAACQTRSARSGGASGPTKRKRLELFK