Protein
4-epi-cubebol synthase ((2E,6E)-farnesyl diphosphate cyclizing)
Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Function
Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpenol 4-epi-cubebol via a 1,10-cyclization, which requires the abstraction of the pyrophosphate from FPP to yield a (E,E)-germacradienyl cation (PubMed:27666571, PubMed:27829890). The only accepted substrate is (2E,6E)-farnesyl diphosphate (FPP) (PubMed:27829890).
Similarity
Belongs to the terpene synthase family.
Sequence
MGTTTTHKFDRPLRLPPLPCPFPSEVNPYVEQVDKETLEWLIDSEMLDDAETVERYRQAKYGWLSARTYPYAEHHTLRLVSDWCVWLFAFDDAFCESDRRAAEIARALPQLYAVLEDLDVGSEVDDVFAKSLLEIKGRIAAYGDDEQLDRWRNVTKDYLFAQVWEAANREDEVVPSLEDYIFMRRRTGAMLTVFALIDVASGRSLSADEWRHPGMRAITESANDVVVWDNDLISYAKESNSGNSRNNLVNVLAEHRHYSRQEAMEEIGEMRNQAIADMVAVRPSLEALGSDAVLAYVRGLEFWISGSVDYSLTSSRYTDAWRTARQPSIR