Protein
4-hydroxyproline 2-epimerase
Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Function
Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Displays no proline racemase activity.
Similarity
Belongs to the proline racemase family.
Sequence
MRTKRVFHAVDSHTEGMPTRVITGGVGVIPGSTMAERREHFLAEMDHVRTLLMYEPRGHSAMSGAILQPPTRPDADYGVLYIEVSGCLPMCGHGTIGVATVLVETGMVEVVEPVTTIRLDTPAGLVVAEVRVEDGAATAVTITNVPSFSAGLDRTVKVPGIGEVTYDLAYGGNFYAILPIESVGLPFDRAHKQQILDAGLAIMDAINEQDEPVHPLDAGIRGCHHVQFTAPGSDARHSRHAMAIHPGWFDRSPCGTGTSARMAQLHARGELPLDTDFVNESFIGTRFVGRLVEETEVTDLPAVVPTITGRAWVTGTAQYFLDPRDPFPEGFLL