Protein
4-hydroxyproline 2-epimerase
Organism
Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB 9113)
Function
Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). May be involved in a degradation pathway of t4LHyp, which would allow S.novella to grow on t4LHyp as a sole carbon source.
Similarity
Belongs to the proline racemase family.
Sequence
MARHSFFCIDGHTCGNPVRLVAGGGPNLQGANMIEKRAHFLAEYDWIRTGLMFEPRGHDMMSGSILYPPTRPDCDVAILFIETSGCLPMCGHGTIGTVTMAIEHGLVTPKIPGVLMLDTPAGVVKAEYRQEGQYVEEVRITNVPAFLYARGLTAECPGLGEVMVDVAYGGNFYAIVEPQEHFRDMADFTAGELIGMSGALRKALNAKYEFVHPEKPEIRGLSHILWTGAPKHAEAHARNAVFYGDKAIDRSPCGTGTSARIAHWAANGKLKVGDDFVHESIIGSLFKGRVEATARVGNVDAIIPSIGGWARMTGYNTIFIDDRDPFAHGFVVV