Smoktcr

Sperm motility kinase Tcr mutant form

484 amino acids

While the main function of Smoks is to control sperm motility, the role of Smok-Tcr, with reduced kinase activity, is to counterbalance a signaling impairment caused by the distorter/sterility loci, giving t-sperm an advantage in reaching the oocytes. Transmission ratio distortion also called segregation distortion is the name given to the phenomenon above-mentioned. Being associated with the T-complex, it allows males heterozygous for a complete t-haplotype to preferentially transmit the t-haplotype chromosome.

Belongs to the protein kinase superfamily. Tyr protein kinase family. Smok subfamily.

54.619 kDa

MEKFHAQYEMLETIGQGGCAQVKLARHRLTGTHVAVKVIVKRECWFNPVMSEAELLMMTDHPNIISLLQVIETKKKVYLIMELCEGKSLYQHIQNAGYLQEDEARPLFKQLLSAMNYCHNQGIVHRDLTPDNIMVEKDGKVKIIDFGLGTQEKPGQNHNLFCEIYPFSTPEVLFNRPYDMRKIDVWGLGVVLYFMVTGKILFDTASVEKLRKQIVAEKCSVPCRLSVELQDLIRLLMTDIPELRPTVAEVMVHPWVTEGSGVLPDPCEEHIPLKPDPAIAKAMGFIGFQAQDIEDSLCQRKFNETMASYCLLKKQILKECDRPIRAQPMNPSVTPLSSLVDAPTFHLGLRRTETEPTGLRLSDNKEVPVCGNSTSKKRERSFSGPGVLSRPINTTPTMDQTHTRTWSGPCIYSNVCTIHPNSINESTEGHISTSAEDKPVHSRGWPRGIKGWTRKIGNAMRKLCCCIPSKETSHLGQRRVCPKI