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Slc46a1

Gene
slc46a1
Protein
Proton-coupled folate transporter
Organism
Danio rerio
Length
481 amino acids
Function
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. Shows a higher affinity for folate than heme (By similarity).
Similarity
Belongs to the major facilitator superfamily. SLC46A family.
Mass
52.188 kDa
Sequence
MEDSDTSAILAEDSESVDSRTVCRCFRVTENKAPPPCSCPLSVTVEPVMFLSTFSIVLQAPLCTQYLWDRLSEDVGYNGTKTGGCNASTVHDPLQTEVETLTAHWSLYINLGGFLVGLFMVILLGSWSDRAGRRLVLIIPSLGLAVQAAVYLTVMYLKLPVFWFLIGRICSGLSGDFNAILAGCFAYVADTSERGSRTFRVAILEACLGLAGMFASIIGGQWRRAQGYINPFWLVLATNLTAALYAYLFVPETVTPDPQARLFSTRHHQAVCRLYSSDAPPGRRSKLWLYILCFFLVVTVHLGCSDLYVLYELSAPLCWGPELIGYGSAAKHLAYLTSLTGLRAMQCCLEDSWVALVGLTSNMVGLVVISVADTTALMFTGYGLCFLFMASTPVLRSKLSKLVDPAEQGALFASVACVEGLCSLVSSGVFNALYPATLHFMKGFPFVFGAAILLIPAGIIGGLGCQEKRESRENREGFGIS

Gene
slc46a1
Protein
Proton-coupled folate transporter
Organism
Xenopus laevis
Length
463 amino acids
Function
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. Shows a higher affinity for folate than heme (By similarity).
Similarity
Belongs to the major facilitator superfamily. SLC46A family.
Mass
51.2 kDa
Sequence
MVSPDDSPEIRDRPRPRRCLLPASVTVEPVIFLSMFALALQGPLATQYLWDRLSADIGFNGTRTVGCAMNGSKSAGPEQQEVETLTAHWSLYINLGGFLVGLFSVMLLGPWSDKVGRRPVLMLPCIGLALQAAVYLLVMYQELHVGYFLIGRFISGISGDFNMILAGCFAYIADVSDRQSRTFRVAVLEACLGIAGMVASIIGGHWRKAQGYINPFWLVFAVNLFTALYVYFCVEESVKDKKPARLFTHRHYQSFFRLFTVQGENNRRRKLFLYSLALLVVVTVHMGAKNLFVLYELSYPLCWDSDLIGYGSAAEHLTYLSSLAGLRLFQLCLADSWVAEMGFISNISGLVVISLASTTPIMFTGYGLRFFAMATTPVIRSKLSKMVEEGEQGALFSSVACVEGLSFLLATGLFNSLYPATLHFMKGFPFLLGALLLLIPAGIIGLIEVCEQKPMYSQFSEIS

Gene
Slc46a1
Protein
Proton-coupled folate transporter
Organism
Rattus norvegicus
Length
459 amino acids
Function
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme (By similarity).
Similarity
Belongs to the major facilitator superfamily. SLC46A family.
Mass
50.095 kDa
Sequence
MEGRVSPVGSSHRLLTAAVLFRGPVEPLVFLANFALVLQGPLTTQYIWHRISTELGYNGTRHRENCGNQSADPVLKEVETLTSHWTLYMNVGGFLVGLFWSTLLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLQLHIGFFVLGRALCALLGDFNGLLAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLGGHWLRAQGYANPFWLALAVLIVMTLYAAFCFGETVKEPKSTRLFTLRHHRSIVQLYVVPAPEKSRMHLALYSLAIFVVVTVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLGLRLLQFCLADTWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALFSAVACVNSLAMLMASGIFNSLYPATLNFMKGFPFLLGAGLLFIPAILIGVLEKVNPHPEFQQFPQNS

Gene
SLC46A1
Protein
Proton-coupled folate transporter
Organism
Bos taurus
Length
459 amino acids
Function
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.
Similarity
Belongs to the major facilitator superfamily. SLC46A family.
Mass
50.428 kDa
Sequence
MEGRANSPGEPRAWPTRSVLCRGCVEPLVFLANFALVLQGPVTTQYLWHRFSADLGYNGTRHRDSCSNHSVDPIAQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDCVGRRPLLVLASLGLLLQTVLSIFVVQLHLHIGYLVLGRILCALLGDFSGLLAASFASVADVSSSRTRTIRMALLEACIGVAGMLASFIGGFLLQEQVYVNPFWLALAVLTVMTLYAAFCFGETVKERTPTRLFTLRHHRSVIQLYVTQAPEKSRKHLALYSLAIFVMITVHLGAQDILTLYELSAPLCWDSRLISYGSAAQQLPYLTSLLGLRLLQYCLADTWVAEIGLVFNILGMMVFAFATITPLMFTGYGLLFLSLVVTPIIRAKLSRLVRQSEQGALFSALACVNGLAMLMASGIFNSLYPATLNLMKGFPFLLAAGLLFIPAILMGILERDNHCPEFQEFSQSP

Gene
SLC46A1
Protein
Proton-coupled folate transporter
Organism
Homo sapiens
Length
459 amino acids
Function
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.
Similarity
Belongs to the major facilitator superfamily. SLC46A family.
Mass
49.771 kDa
Sequence
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP

Gene
Slc46a1
Protein
Proton-coupled folate transporter
Organism
Mus musculus
Length
459 amino acids
Function
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.
Similarity
Belongs to the major facilitator superfamily. SLC46A family.
Mass
50.089 kDa
Sequence
MEGRVSSVGSPHSFLNAPVLFRGPVEPLVFLANFALVLQGPLTTQYLWHRFSTELGYNGTRHRENCGNQSADPLMKEVETLTSHWTLYMNVGGFLVGLFWSTLLGAWSDRVGRRPLLVLASLGLLLQAVVSIFVVQLELHVGFFVLGRALCALLGDFNGLLAASFASVADVSSNHSRTFRMALLEACIGVAGTLASLLGGHWLRAQGYANPFWLALALLIVMALYAAFCFGETVKEPKSTRLFTLRHHRSIARLYVVPAPEKSRMHLALYSLAIFVVVTVHFGAQDILTLYELSAPLCWDSKLIGYGSAAQHLPYLTSLLGLRLLQFCLADTWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVTTPVIRAKLSKLVSESEQGALFSAVACVNSLAMLMASGIFNSIYPATLNFMKGFPFLLGAGLLFIPAILIGVLEKVNPHPEFQQFPQSP