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Sir2A

Gene
sir2A
Protein
NAD-dependent deacetylase sir2A
Organism
Dictyostelium discoideum
Length
512 amino acids
Function
NAD-dependent deacetylase, which plays an important role in the regulation of transcriptional repression.
Similarity
Belongs to the sirtuin family.
Mass
57.413 kDa
Sequence
MYAVNPIECIHLKDEYDTCINKSIFDKDLKITKCHACNDESENWICMTCGVVSCSRHVNGHAGEHFENTKHPISASFSDHSFWCYTCDTYVHNTPLFDICEILENIKSSNKKDKIVPKKDQKEEEEEDQVVPSASITTSSTTTSISKQTTVNNTTTTSSSSTTTTTTTTSTTINNNEEEEESESETDESSSEGEESLSLIQRMREMIFGVGRGPKIVAPSEQEESEEDESCVLKKPTIEEIAKYINSAKCKNIIVMTGAGISVAAGIPDFRSPKTGLYEKLDKYDLPYREAIFDIEYFKKNPKPFYVLSKELFPGSFNPTTVHYFIKLLSDKGLLLRNFTQNIDTLERIAGIPANKLVEAHGSFATSHCVSCKKEYSTEYVKERIFKDELPECTETSGCKGIVKPDIVFFGESLPSRFNDCAREDFTKCDLLLVIGTSLKVHPFASLINFAKGCPRVLINFEEVGTNPYGGFKFNQPSNKLDVKCIGDCQTLVLDLIKLLGWENEFNQIVKN

Gene
Sir2A
Protein
NAD-dependent protein deacylase Sir2A
Organism
Plasmodium falciparum (isolate 3D7)
Length
273 amino acids
Function
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of medium and long chain fatty acyl groups from lysine residues. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2B to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance. Can ADP-ribosylate both histones and itself. May also have a role in telomeric end protection.
Similarity
Belongs to the sirtuin family. Class III subfamily.
Mass
30.344 kDa
Sequence
MGNLMISFLKKDTQSITLEELAKIIKKCKHVVALTGSGTSAESNIPSFRGSSNSIWSKYDPRIYGTIWGFWKYPEKIWEVIRDISSDYEIEINNGHVALSTLESLGYLKSVVTQNVDGLHEASGNTKVISLHGNVFEAVCCTCNKIVKLNKIMLQKTSHFMHQLPPECPCGGIFKPNIILFGEVVSSDLLKEAEEEIAKCDLLLVIGTSSTVSTATNLCHFACKKKKKIVEINISKTYITNKMSDYHVCAKFSELTKVANILKGSSEKNKKIM