Protein
SAGA-associated factor 11 homolog 2
Organism
Drosophila willistoni
Function
Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Binds independently on SAGA to promoters in an RNA-dependent manner. Binds to mRNA and is essential for total mRNA export from the nucleus. Required to counteract heterochromatin silencing. Controls the development of neuronal connectivity in visual system by being required for accurate axon targeting in the optic lobe. Required for expression of ecdysone-induced genes such as br/broad.
Similarity
Belongs to the SGF11 family.
Sequence
MSTTAAATTTTPSTMSNNQGQGQTTIPGTGTGTGAAKTTNRIINNFRALLKDPNNLDEAVNYLYRTLIDDATAGIFIETHHLRKTGNLAALDGLAEESAYRICEMPNLDIFGISTAKKPMDCTCPNCDRLVAAARFAPHLEKCMGMGRISSRIASRRLATKEGTSASSSSSSTYMHSGGDRGGGGGHHAGAGGTDDEDDVDWSSDKRKKKSTQSSRNNGSKKNNGKTF