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SelR

Gene
SelR
Protein
Methionine-R-sulfoxide reductase B1
Organism
Drosophila melanogaster
Length
208 amino acids
Function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by Mical on actin thereby promoting filament repolymerization.
Similarity
Belongs to the MsrB Met sulfoxide reductase family.
Mass
23.299 kDa
Sequence
MFALSARHALRRTRIFAIPRFFADSRQDSDNPDKRYSGPAATMDNKSEKVTVNKEELRKRLTPVQYQVTQEAGTERPFTGCYNKHYEKGVYQCIVCHQDLFSSETKYDSGCGWPAFNDVLDKGKVTLHRDASIPGGNILLLIAHPERIRTEVRCARCNAHMGHVFEDGPKPTRKRYCINSASIEFVNADPATSSPPVATPTAAPIAQQ