Protein
Outer capsid protein VP2
Organism
Bluetongue virus 1 (isolate South Africa vaccine)
Function
The VP2 protein is one of the two proteins (with VP5) which constitute the virus particle outer capsid. It is the major target of the host immunogenic response. Responsible for viral attachment to target host cell, probably by binding to sialic acid. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity).
Similarity
Belongs to the orbivirus VP2 family.
Sequence
MDELGIPVYKRGFPEHLLRGYEFTIDVGTKIESVGGRHDVTKIPEMNAYDIKQESIRTALWYNPIRNDGIVLPRVLDITLRGYDERRAVVESTRHKSFHTNDQWVQWMMKDSMDAQPLKVGLDDQSRNVAHSLHNCVVKIDSKKADTMSYHVEPIEDASKGCLHTRTMMWNHLVRIETFHTAQEVHILFKPTYDIVVHAERRDRSQPFRPGDQTLINFGRGQKVHMNHNSYDKMVEGLTHLVMRGKMPEVIRDDIASLDEICNRWIQSRHDPGEVKAYELCKILSTIGRKVLDREKEPEDEANLSIRFQEAIDNKFRQHDPERLKIFEHGNQRRDEDRFYILLMIAASDTFNTRVWWSNPYPCLRGTLIASETKLGDVYSMMRSWYDWSVRPTYTPYEKTREQEEYIYGRVNLFDFVAEPGIKIVHWEYRLNHSTREITYAQGNPCDLYPEDDDVIVTKFDDVAYGQMINEMINGGWNQEQFKMHKILKTEGNVLTIDFEKDAKLTTNEGVTMPEYFNKWIIAPMFNANVRIKHEEIAQRQSDDPMVKRTLSPITADPIELQRLTLARFYDIRPALRGQALSRQQAQSTYDEEISKKAGYAEVLKRRGIVQIPKKPCPTVTAQYTLERYALFIINYLQQHVARDCDEEAIYEHPKADHELEIFGESIVDISQVIVLVFDLIFERRRRVRDVYESRYIIARIREMRGKEKLNVIAEFFPTYGSLLNGLSGATVVQDIMYLNFLPLYFLVGDNMIYSHRQWSIPLLLYTHEVMVIPLEVGSYNDRCGLIAYLEYMVFFPSKAIRLSKLNEAHAKIAREMLKYYANTTVYDGGDNSNVVTTKQLLYETYLASLCGGFLDGIVWYLPITHPNKCIVAIEVSDERVPASVRAGRIRLRFPLSARHLKGVVIIQVDLGGRFTVYSEGIVSHRVCKKNLLKYMCDIILLKFSGHVFGNDEMLTKLLNV