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Sap30

Gene
SAP30
Protein
Histone deacetylase complex subunit SAP30
Organism
Homo sapiens
Length
220 amino acids
Function
Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.
Similarity
Belongs to the SAP30 family.
Mass
23.306 kDa
Sequence
MNGFTPDEMSRGGDAAAAVAAVVAAAAAAASAGNGTGAGTGAEVPGAGAVSAAGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFRSIPVNEKDTLTYFIYSVKNDKNKSDLKVDSGVH

Gene
Sap30
Protein
Histone deacetylase complex subunit SAP30
Organism
Mus musculus
Length
220 amino acids
Function
Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.
Similarity
Belongs to the SAP30 family.
Mass
23.231 kDa
Sequence
MNGFTPEEMSRGGDAAAAVAAVVAAAAAAASAGNGNAAGGGAEVPGAGAVSASGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFKSIPVNEKDTLTCFIYSVRNDKNKSDLKADSGVH

Gene
SAP30
Protein
Transcriptional regulatory protein SAP30
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
201 amino acids
Function
Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Similarity
Belongs to the SAP30 family.
Mass
23.026 kDa
Sequence
MARPVNTNAETESRGRPTQGGGYASNNNGSCNNNNGSNNNNNNNNNNNNNSNNSNNNNGPTSSGRTNGKQRLTAAQQQYIKNLIETHITDNHPDLRPKSHPMDFEEYTDAFLRRYKDHFQLDVPDNLTLQGYLLGSKLGAKTYSYKRNTQGQHDKRIHKRDLANVVRRHFDEHSIKETDCIPQFIYKVKNQKKKFKMEFRG

Gene
Sap30
Protein
Histone deacetylase complex subunit SAP30 homolog
Organism
Drosophila melanogaster
Length
173 amino acids
Function
Component of the class 1 Sin3A-histone deacetylase (Rpd3) complex (HDAC). Appears to be a non-essential subunit of this complex which is not required for cell cycle regulation of progression through the G2 phase of the cell cycle.
Similarity
Belongs to the SAP30 family.
Mass
20.192 kDa
Sequence
MNNGFSTGEEDSRGHTDQTCCLIDDMERCRNQAGYASYSKRIQKTVAQKRLKLSSDPAAQHIYICDHHKERIQSVRTKRRRKDSEDDSNETDTDLHEFPDLYQLGVSTLRRYKRHFKVQTRQGMKRAQLADTIMKHFKTIPIKEKEIITFFVYMVKMGSNKLDQKNGLGNDTT

Gene
Sap30
Protein
Histone deacetylase complex subunit SAP30 homolog
Organism
Drosophila pseudoobscura pseudoobscura
Length
173 amino acids
Function
Component of the class 1 Sin3A-histone deacetylase (Rpd3) complex (HDAC). Appears to be a non-essential subunit of this complex which is not required for cell cycle regulation of progression through the G2 phase of the cell cycle (By similarity).
Similarity
Belongs to the SAP30 family.
Mass
20.25 kDa
Sequence
MNNGFSTGEEDSRGHADQTCCLIDDMERCRNQAGYASYSKRIQKTVAQKRLRLSSDPSAQHIYICDHHKERIQSVRTKRRRKDSEDDSNETDTDLHEFPDLYQLSVSTLRRYKRHFKVQTRQGMKRAQLADTIMKHFKTIPIKEKEIITFFVYMVKMGTNKLDQKNGIGNDTT