STP2

Transcriptional regulator STP2

584 amino acids

Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes. Required for efficient alkalinization through the release of ammonia from the cells produced during the breakdown of amino acids, and subsequent switch to the hyphal form.

67.011 kDa

MSVAITSNNNKQPQPQPQPHLKVVNNNSTFNLYTWLRSVFQYCISLIISYTSNWLLVNNDNNNNNININYKSNNNDNNNASTSLQPKISNVKAESMKIFPDLQKSNFTTYYTTEKPLHQDVLKPVICSTGITSRILPYTNEKGELEWKFTEVQGKELDEFKMHPQQQQQQQEVKQELSPAESNESNESLAKDSSTTPASISDSPSHSETESTVSSTIIANSNQIFKCPSCDAEFRVRGYLTRHMKKHSTKKAYTCPFHDKSIYVDENNITHKCHSSGGFSRRDTYKTHLKSRHFNYAKPIKSAERSKVPGQCAMCGEHFNSAEIWCEIHVEGGECKFLPMGFKGKSRIKNRLKKQIQKNKMIDPELVPFASKVLEEVEQERQKKKNYRTTGTGSESSIQSQESESSINSTPLSMQISAPVPMPVSIQQQHQHQHQHHHHVQNQHQQHVNQQQSIATPASIYSSSASSTSSYESTHSPYTPQSSRSPLSHMYNPQQPPYFNQIAQAHQQDGQKNQVKDDYDDEYCLDVDQLNTTFVNETVANYLQIHDFHSMNQYQPGQQQQQQQQQQQQQQQRQHQQQQPSMYF

STP2

Transcription factor STP2

541 amino acids

Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases BAP2 and BAP3. Binding to promoters is facilitated by DAL81 (By similarity). Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response. Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes.

60.792 kDa

MPILSLSSTRNSVLTRIYDYLKALVQQVIVPNVEDDKSSKSTPFEKLEPAKQNHPQKDCCATEKDDLVDVSELFPKQNNKQLSLTSKSSVVPCALNLDNLETPFSIKIDNNGAVTTQLNLDEPILRGPSRGEPAKLQNDLISSPPLEESYINNDQYKALFPSNFLPITPVSSVITPASKKSIDESPLSDEVQGIADESSETLPYICHYCDARFRIRGYLTRHIKKHAKRKAYHCPFFDNSISQELRCHTSGGFSRRDTYKTHLKSRHFTYPEGVKPQDRNKSPGVCTQCGEHFSTSESWVENHIEAGSCKGLPEGYSEGIREKKKTSKMKMIKTSDGQTRFISSDESVSEPALQNKNCIEATVMQSKERPNDKIIPTKTEKNDFGIGTQWFERKQISRPTQTTQSRGPTEVQNLKEWSIISPPILSPQNASSVPQEYQSSRYTLHMDSPALSSASSALSPLSGDPITTTETNKSYPLDSEQSLLEPDKTEEDAINQSKESNMISINEMLQKQMDFELLGENHLKETQDYLALYKKAYGIEF

STP2

Sugar transport protein 2

498 amino acids

Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, 3-O-methylglucose, xylose, mannose, fructose and galactose.

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

55.023 kDa

MAVGSMNVEEGTKAFPAKLTGQVFLCCVIAAVGGLMFGYDIGISGGVTSMDTFLLDFFPHVYEKKHRVHENNYCKFDDQLLQLFTSSLYLAGIFASFISSYVSRAFGRKPTIMLASIFFLVGAILNLSAQELGMLIGGRILLGFGIGFGNQTVPLFISEIAPARYRGGLNVMFQFLITIGILAASYVNYLTSTLKNGWRYSLGGAAVPALILLIGSFFIHETPASLIERGKDEKGKQVLRKIRGIEDIELEFNEIKYATEVATKVKSPFKELFTKSENRPPLVCGTLLQFFQQFTGINVVMFYAPVLFQTMGSGDNASLISTVVTNGVNAIATVISLLVVDFAGRRCLLMEGALQMTATQMTIGGILLAHLKLVGPITGHAVPLIVLILICVYVSGFAWSWGPLGWLVPSEIYPLEVRNAGYFCAVAMNMVCTFIIGQFFLSALCRFRSLLFFFFGIMNIIMGLFVVFFLPETKGVPIEEMAEKRWKTHPRWKKYFKD