Protein
Serine/threonine-protein kinase 10
Organism
Rattus norvegicus
Function
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo (By similarity).
Similarity
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Sequence
MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNDVWEILGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYYDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCETMKDAPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSTEFRDFLKIALDKNPETRPSAAQLLQHPFVSTVTSNKALRELVAEAKAEVMEEIEDGKEDGSEKDAVSAVPPPVNHTQDSSANGTQPSLNSDKLLQDSSTPLPPSQPQEPVNGPCNQPSGDGSPQNTSPADEVSKNDNGLKVPVPLRKSRPLSVDARIQVTEEKQITDQAENPSSAASKPPKVNQSRPNSSALETLGVETLANGGLELPGSVTPNHSKRASDCSNLSTSESMDYGTSLSADLSLNKETGSLSLKGSKLHNKTLKRTRRFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSTKHELQLEQMHRRFEQEINAKKKFYDVELENLERQQKQQVEKMEQDHSVRRREEAKRIRLEQDRDYARFQEQLKQMKKEVKRSIEKALRKQRQESMRMGQDSHTQKKQRLDRDFVAKQKEDLELAMKKLTAENRREICDKERDCLNKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHDLLRKHEKEREQMQRYNQRMMEQLKVRQQQEKARLPKIQRSDGKTRMAMYKKSLHINGAGSASEQREKVKQFSQQEEKRQKAERLQQQQKHENQMRDMVAQCESNMNELQQLQNEKCHLLVEHETQKLKALDESHNQSLKEWRDKLRPRKKALEEDLNQKKREQEMFFRLSEEAETRPTTPNRASKFFPYSSGDAS