Function
Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system (By similarity).
Sequence
MAEPRTLLLLCVLVLCLSDSSFIRGQTVRSKRCDIHTKFVTHTPCTACAAIRRQLCPWGWSRNFPEKILLDCRYELQLRGAAISLSGCSQECWKDVVQKACCPGYWGSQCFECPGGPATPCSGHGTCLDGIEGNGTCVCQGNFSGSVCQECRDPNRFGPDCQSVCNCVHGVCSHGPRGDGSCRCFAGYTGPHCDQELPVCQSLKCPQNSQCSAEAPTCKCLPGYTQQDNVCLAPDPCQPSACSPLARCSVTPQGQAQCQCPENYHGDGKVCLPRDPCLTNFGGCPSNSTFCLYRGPGKATCMCRPGMTSINNNASEGCHVSCKPHSCDRSATCQVTPDRKTSCVCKNDEVGDGHACYGHLLHEVRRANQNGLVFLRLRAAIAMLEQGCQEILTTSGPFTVLVPSMFSVSSVSSNMNATLAQQLCRQHVIAGEHMLENAGPPSTRRWWTLAGQEVTITFKNMRYAYKYEDQPQQFSIHKANYIAANGVFHTVTALRWQLPPPLPGDSKKTVGQILASTEVFTRFETILENCGLPSILDGPGPFTVFAPSNEAVDSLRDGRLIYLFTAGLSKLQELVRYHIYNHGQLTVEKLISKGRVLTMANQVLTVNISEGGRILLGPGGIPVRRVDVPAANGVIHMLEGILLPPTILPILPKHCDEEQHQTVLGSCVDCQALNTSVCPPNSVKMDIFPKECVYIHDPNGLNVLKKGCADYCNQTITKRGCCKGFFGPDCTQCPGGFSNPCYGKGNCSDGVRGNGACLCFPDYKGIACHICSDPKKHGEQCQEDCGCVHGLCDNRPGSGGVCQQGTCAPGFQGRFCNESMGNCGSTGLAQPCHSDAHCVIQEGVARCVCHDGFEGNGFSCKRSNPCSRPDRGGCSENAECVPGDLGTHHCICHKGWSGDGRICVAIDECGLDTRGGCHADALCSYVGPGQSRCTCKLGFAGNGYECSPIDPCRVGNGGCHGLATCKAVGGGQRVCTCPPHFGGDGFSCYGDIIQELEANAHFSAFSQWFKNSSITLPADSRVTALVPSESAIRRLSLEDQAFWLQPKMLPELARAHFLQGAFSEEELARLNGQQVATLSATTRWQIHNISGKVWVQNATVDVPDLLATNGILHIVSQVLLPPRGDMQTGPGLLQQLDSVPAFRLFGEQLKHHKLVAQIEAAKAYTIFVPTNHSLETQGNNSVLGIDTVRHHVILGEALSVEVLRKGGHRNSLLGPAHWLVFYNHSGQPEVNHMPLEGPLLEAPGSSLFGLSGILAVGSSRCLHSHAEALREKCINCTRKFRCTQGFQLQDTPRKSCVYRSGLSFSRGCSYTCAKKIQVPDCCPGFFGTLCEPCPGGLGGVCSGHGQCQDRFLGNGECRCQEGFHGTACEMCELGRYGPTCSGVCDCDHGLCQEGLRGNGSCVCHAGWQGLRCDQKITDHQCPKKCDPNANCIQDSAGIPACVCAAGYSGNGSYCSEVDPCASGHGGCSPYANCTKVAPGQRTCTCQDGYTGDGELCQEINSCLVHNGGCHVHAECIPTGPQQVSCSCREGYSGDGIQTCKLLDPCSQNNGGCSPYAVCKSTGDGQRTCSCDATHTVGDGITCHGRVGLELLRNKYASFFSLHLLEYKELKGDGPFTVFVPHADLISNMSQDELARIRAHRQLVFRYHVVGCRKLWSQEMLDQGYITTLSGHTLRVSEREGSIYLNDFARVVSSDLEVVNGVLHFIDHVLLPPDVLHWESGAIPIPQRNVTAAAESFGYKIFSRLLTVAGLLPMLQDASHRPFTMLWPTDSALQALPPDRKNWLFHEDHRDKLAAILRGHMIRNIEALASDLPNLGQLRTMHGNTISFSCGLTRPGELIVGEDEAHIVQRHLTFEGGLAYGIDQLLEPPDLGARCDRFEPQPLQMKTCSICGLEPPCPRGSREQGSPETCWRHYSKFWTTPLHSISMRGAYWIPSSFWNRNHMSRGCHRNCVTTVWKPSCCPGHYGINCHACPGGPRSPCSDHGVCLDGIRGSGQCNCHPGFAGTACELCAPGAFGPQCQACRCTQHGRCDEGLGGSGSCFCDEGWTGARCEVQLELQPVCTPPCAPQAVCRLGNSCECSLGYEGDGRVCTVADLCQKGHGGCSKHANCSQVGTVVTCTCLPDYEGDGWSCRARDPCLDGHRGGCSEHADCLNTGPNTRRCECHVGYVGDGLQCLEELEPPVDRCLGGSSPCHTDALCTDLHFQEKQAGVFHIQATSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNRVGVVSLGVRKNLSELWDAYCYRVQDVACQCRAGFVGDGISTCNGKLLDVLAATANFSTFYGMLLGYANATQRGLEFMDFLEDELTYKTLFVPVNKGFVDNMTLSGPDLELHASNATFLSINASRGTLLPAHSGLSLFISDTGPDNTSLVPLAPGAVVVSHVIVWDIMAFNGIIHALASPLLMPPQTRAVLGSEPPPVALSLGVVVTSGTLLGLVAGALYLRARGKPPGFSFSAFQAEDNADDDFSPWQEGTSPTLVSVPNPVFGSSDIFCEPFDDSVLEEDFPDTQRVLKVK