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SSL10

Gene
SSL10
Protein
Protein STRICTOSIDINE SYNTHASE-LIKE 10
Organism
Arabidopsis thaliana
Length
374 amino acids
Similarity
Belongs to the strictosidine synthase family.
Mass
41.001 kDa
Sequence
MTMMIITVFLTVIAAVLAILVKNSQTGSGIFAPPEISGSRDVFPSAKVVNLTGASGPESIAFDPAGEGPYVGVSDGRILKWRGEPLGWSDFAHTSSNRQECARPFAPELEHVCGRPLGLRFDKKTGDLYIADAYFGLLVVGPAGGLAKPLVTEAEGQPFRFTNDLDIDEQEDVIYFTDTSARFQRRQFLAAVLNVDKTGRFIKYDRSSKKATVLLQGLAFANGVALSKDRSFVLVVETTTCKILRLWLSGPNAGTHQVFAELPGFPDNIRRNSNGEFWVALHSKKGLFAKLSLTQTWFRDLVLRLPISPQRLHSLFTGGIPHATAIKLSESGKVLEVLEDKEGKTLRFISEVEEKDGKLWIGSVLVPFLGVYDL

Gene
ssl10
Protein
Staphylococcal superantigen-like 10
Organism
Staphylococcus aureus (strain NCTC 8325)
Length
227 amino acids
Function
Plays a role in the inhibition of host complement activation via the classical pathway by interacting with the Fc region of human IgG and thereby interfering with the IgG/C1q interaction (PubMed:19913916). Inhibits also the penultimate step of plasma clotting by interacting with prothrombin/F2 and coagulation factor X/F12. Does not affect the protease activity of thrombin but interferes with the conversion of prothrombin to thrombin (PubMed:23754290, PubMed:28193526). Interacts with human receptor CXCR4 and specifically inhibits CXCL12-induced calcium mobilization and cell migration (PubMed:19308288).
Similarity
Belongs to the staphylococcal/streptococcal toxin family.
Mass
26.111 kDa
Sequence
MKFTALAKATLALGILTTGTLTTEVHSGHAKQNQKSVNKHDKEALYRYYTGKTMEMKNISALKHGKNNLRFKFRGIKIQVLLPGNDKSKFQQRSYEGLDVFFVQEKRDKHDIFYTVGGVIQNNKTSGVVSAPILNISKEKGEDAFVKGYPYYIKKEKITLKELDYKLRKHLIEKYGLYKTISKDGRVKISLKDGSFYNLDLRSKLKFKYMGEVIESKQIKDIEVNLK

Gene
ssl10
Protein
Staphylococcal superantigen-like 10
Organism
Staphylococcus aureus (strain Newman)
Length
227 amino acids
Function
Plays a role in the inhibition of host complement activation via the classical pathway by interacting with the Fc region of human IgG and thereby interfering with the IgG/C1q interaction. Inhibits also the penultimate step of plasma clotting by interacting with prothrombin/F2 and coagulation factor X/F12. Does not affect the protease activity of thrombin but interferes with the conversion of prothrombin to thrombin. Interacts with human receptor CXCR4 and specifically inhibits CXCL12-induced calcium mobilization and cell migration.
Similarity
Belongs to the staphylococcal/streptococcal toxin family.
Mass
26.111 kDa
Sequence
MKFTALAKATLALGILTTGTLTTEVHSGHAKQNQKSVNKHDKEALYRYYTGKTMEMKNISALKHGKNNLRFKFRGIKIQVLLPGNDKSKFQQRSYEGLDVFFVQEKRDKHDIFYTVGGVIQNNKTSGVVSAPILNISKEKGEDAFVKGYPYYIKKEKITLKELDYKLRKHLIEKYGLYKTISKDGRVKISLKDGSFYNLDLRSKLKFKYMGEVIESKQIKDIEVNLK