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SRB6

Gene
SRB6
Protein
Mediator of RNA polymerase II transcription subunit 22
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
121 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 22 family.
Mass
13.249 kDa
Sequence
MSNQVLLDKLDRTTESLSQALAQLVKLSSIDRASADSDGDNDGTTDSITSVATNGVMMVHAHTTQLIRGVQDLLVITRAIRETWVLGQIPKKNGDEDAIDYEKCERLLEKAMDDFFGPVAL

Gene
SRB6
Protein
Mediator of RNA polymerase II transcription subunit 22
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
121 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 22 family.
Mass
13.65 kDa
Sequence
MSNQVLLDKLDRTTETLSNTLIHLAKLSDIEFGGKDTEQPRSSSGLATVSSSGVQMSNNYTMQLIKGIQDLLVITRSIREKWVLSQLPENEELSMFESEETLENCRKLVQESMETLLNDMP

Gene
SRB6
Protein
Mediator of RNA polymerase II transcription subunit 22
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
121 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Similarity
Belongs to the Mediator complex subunit 22 family.
Mass
13.863 kDa
Sequence
MSNQALYEKLEQTRTILSVKLAELINMTTIADRNDDDEGSFAQENSELAVATTSVMMVNNQTMQLIKNVQDLLILTRSIKEKWLLNQIPVTEHSKVTRFDEKQIEELLDNCIETFVAEKTT

Gene
SRB6
Protein
Mediator of RNA polymerase II transcription subunit 22
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
121 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 22 family.
Mass
13.249 kDa
Sequence
MSNQVLLDKLDRTTESLSQALAQLVKLSSIDRASADSDGDNDGTTDSITSVATNGVMMVHAHTTQLIRGVQDLLVITRAIRETWVLGQIPKKNGDEDAIDYEKCERLLEKAMDDFFGPVAL

Gene
SRB6
Protein
Mediator of RNA polymerase II transcription subunit 22
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
121 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 22 family.
Mass
13.65 kDa
Sequence
MSNQVLLDKLDRTTETLSNTLIHLAKLSDIEFGGKDTEQPRSSSGLATVSSSGVQMSNNYTMQLIKGIQDLLVITRSIREKWVLSQLPENEELSMFESEETLENCRKLVQESMETLLNDMP

Gene
SRB6
Protein
Mediator of RNA polymerase II transcription subunit 22
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
121 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
Similarity
Belongs to the Mediator complex subunit 22 family.
Mass
13.863 kDa
Sequence
MSNQALYEKLEQTRTILSVKLAELINMTTIADRNDDDEGSFAQENSELAVATTSVMMVNNQTMQLIKNVQDLLILTRSIKEKWLLNQIPVTEHSKVTRFDEKQIEELLDNCIETFVAEKTT

Gene
SRB6
Protein
Mediator of RNA polymerase II transcription subunit 22
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
115 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 22 family.
Mass
13.546 kDa
Sequence
MQPKSISLLQKIDSIIETIIVKFTNIFENLQDANKTTEILSMESLAMENNCIQIIRLCQDLISISRNLKEIWVLNSIKVTQEKFEWKQEEIDIMFTQFNLLTDKIAEFETDMNKE

Gene
SRB6
Protein
Mediator of RNA polymerase II transcription subunit 22
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
115 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 22 family.
Mass
13.546 kDa
Sequence
MQPKSISLLQKIDSIIETIIVKFTNIFENLQDANKTTEILSMESLAMENNCIQIIRLCQDLISISRNLKEIWVLNSIKVTQEKFEWKQEEIDIMFTQFNLLTDKIAEFETDMNKE

Gene
SRB6
Protein
Mediator of RNA polymerase II transcription subunit 22
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
113 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 22 family.
Mass
12.753 kDa
Sequence
MSNQALLETLNQTTELLSVKLAELAKLASMETNEDTEDCQLSVVTNGLMMVNNQTLQLVRGVQDLILLTRNIREKWLLTQIPEQLTPKEQDSINHEELTELLESCVSEIISDV

Gene
SRB6
Protein
Mediator of RNA polymerase II transcription subunit 22
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
113 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 22 family.
Mass
12.753 kDa
Sequence
MSNQALLETLNQTTELLSVKLAELAKLASMETNEDTEDCQLSVVTNGLMMVNNQTLQLVRGVQDLILLTRNIREKWLLTQIPEQLTPKEQDSINHEELTELLESCVSEIISDV

Gene
SRB6
Protein
Mediator of RNA polymerase II transcription subunit 22
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
112 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 22 family.
Mass
12.347 kDa
Sequence
MSNRSITLLQRVDNATEQLNSKFTDIVNSAKVSSKDKSALAMETYLVEESTSAMVRSLEDLLFVTRSLKEAWILGQIRPVVNKPEDGGEGQLADELLDKIEDTSDGVDKETA

Gene
SRB6
Protein
Mediator of RNA polymerase II transcription subunit 22
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
112 amino acids
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Similarity
Belongs to the Mediator complex subunit 22 family.
Mass
12.347 kDa
Sequence
MSNRSITLLQRVDNATEQLNSKFTDIVNSAKVSSKDKSALAMETYLVEESTSAMVRSLEDLLFVTRSLKEAWILGQIRPVVNKPEDGGEGQLADELLDKIEDTSDGVDKETA