Protein
Transcription elongation factor SPT5
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Function
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
Similarity
Belongs to the SPT5 family.
Sequence
MSGTAEESDKAEAVSVPETVSGSVESQDKEHNSTSSSSDSTDVVGGKKRTIDEVDGSSENNSASVDQLKDAPTDSKPKTEATEDSPIRGNQGNNQENSQENKDDEDDEDDNDDDDNDDDDDEDEDVESYRKKQRRERNRFLDIEAEVSEDEDDEEDEEDSELVREGFITRGDEEDEEDRGGRVDDRLHRELDQNLQKTADEDMHKIAEDFKKRYGRDSSKDYRVQTQGGYVPQRFMLPSVDTAIIWSVRCRPGKEKELVRKLLNKKFNLDKSMGSKKLKILSIFQRDNYTGRIYIEAPKQSVIEKFVNGVPDVYSNQKLLIPVQELPLLLKPTKSDEVRLDVGSYVRIKRGIYKNDLAVIDQISQNNLEALLKIVPRLDYGKNDEIDPDTNQRKAKRATFASRPPPQLFNPTMALRLDQANLFKRDDRHFTYRKEDYVDGYLFKSFKIQYLDTKNIQPTVEELSRFGSKEGDVDLAAIAQTMKKAQASKAMFQPGDRVEVLTGEQRGSRGVVTRSSKDVISVKLSGFSDKSLEFPIASLRKIFELGDHVTVIAGEHEGNAGLVLLVQNGQVTFVSDQTRENLTISANNLSKSMDSTPTSSEYALHDIVELSAKNVACVIQAGHDIFKIIDDSGKVATVTKGSILAKINVARAKVAAVDGNGREIKIGDVVREKIGSRREGQVLYVQNQHIFIRSKTITENAGVFVVNPMNVEAVASKENLMSSALDLSKINPNIASKMGPPQTTQQTRLVGRDVALNKTVRIRSAGYKGQLGIVKDVNGDKATIELHSKNKHITIDKRKLTYFSHEGGEGITYDELVSRRGRTPHTRLGPSYVSAPRHMAAGGAVATNTPQQLPGGMTPGWNAFDGGKTPAVGQNGGTSSWGGASTWGGQGPGGASAWGGAAGNTSTWGGQGATSTWGGASTWGNKSSYGGASSWAASGESGAASAWGGGNKSSYGGTSTWGGNQGGVSAWGGSGNKSQRSKNTGGSSTWGNNQSQHNSGERSAWGNASQHNNSGNRSAWGNQDARGGGSTWGGNN