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SPPL2B

Gene
SPPL2B
Protein
Signal peptide peptidase-like 2B
Organism
Gallus gallus
Length
596 amino acids
Function
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.
Similarity
Belongs to the peptidase A22B family.
Mass
66.397 kDa
Sequence
MAARWAQFLLFSLLSLPQVYCEYGMVHVLSEKGSSKGKDYCILFNSQWAHLPHDLGKASLLQLQDQTASVLCSPSDVPDGGFNNRIPMVMRGNCTFYEKVRLAQINGARGLLIVSRERLVPPGGNRSQYEEIDIPVALLSYSDMLDIVKSFGRSVKGAMYAPNEPVLDYNMVIIFVMAVGTVAIGGYWAGSRDVKERYMKHKRDDGAEKHEDETVDVTPIMICVFVVMCCSMLVLLYFFYDHLVYVIIGIFCLAASIGLYSCLSPFVRRFPLGKCRIPDNNLPYFHKRPQVRILLLAVFCISVSVVWGVFRNEDQWAWVLQDALGIAFCLYMLKTIRLPTFKGCTLLLLVLFVYDVFFVFITPFLTKTGESIMVEVAAGPSDSATHEKLPMVLKVPRLNSSPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGIGLLVTFVALALMQMGQPALLYLVPCTLITSFSVALWRKELAMFWTGSGFAKDLPQPPLVIASVNCPQLPKDSNVPASQQETEEMANPTLHVKELHSPTLAAEEPADNDTKTEQSEVSIAQSEEAAGHNKDDLESKSLNLEQKQLE

Gene
SPPL2B
Protein
Signal peptide peptidase-like 2B
Organism
Homo sapiens
Length
592 amino acids
Function
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).
Similarity
Belongs to the peptidase A22B family.
Mass
64.644 kDa
Sequence
MAAAVAAALARLLAAFLLLAAQVACEYGMVHVVSQAGGPEGKDYCILYNPQWAHLPHDLSKASFLQLRNWTASLLCSAADLPARGFSNQIPLVARGNCTFYEKVRLAQGSGARGLLIVSRERLVPPGGNKTQYDEIGIPVALLSYKDMLDIFTRFGRTVRAALYAPKEPVLDYNMVIIFIMAVGTVAIGGYWAGSRDVKKRYMKHKRDDGPEKQEDEAVDVTPVMTCVFVVMCCSMLVLLYYFYDLLVYVVIGIFCLASATGLYSCLAPCVRRLPFGKCRIPNNSLPYFHKRPQARMLLLALFCVAVSVVWGVFRNEDQWAWVLQDALGIAFCLYMLKTIRLPTFKACTLLLLVLFLYDIFFVFITPFLTKSGSSIMVEVATGPSDSATREKLPMVLKVPRLNSSPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGVGLLVTFVALALMQRGQPALLYLVPCTLVTSCAVALWRRELGVFWTGSGFAKVLPPSPWAPAPADGPQPPKDSATPLSPQPPSEEPATSPWPAEQSPKSRTSEEMGAGAPMREPGSPAESEGRDQAQPSPVTQPGASA

Gene
Sppl2b
Protein
Signal peptide peptidase-like 2B
Organism
Mus musculus
Length
578 amino acids
Function
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity.
Similarity
Belongs to the peptidase A22B family.
Mass
63.824 kDa
Sequence
MAAARLAAALLLLAAQVACEFGVLRVVSQTSRTRSRDYCILYNPQWAHLPHDLSKVSLLKLRDLSTTQLCSYLDVPAEDFTNQIALVARGNCTFYEKVRLAQGSGAHGLLIVSKEKLVPPGGNKTQYEEISIPVALLSHRDLQDIFRRFGREVMVALYAPSEPVMDYNMVIIFVMAVGTVAIGGYWAGSHDVKKYMKHKRDDGPEKQEDEAVDVTPVMICVFVVMCCFMLVLLYYFYDRLVYVIIGIFCLASSTGLYSCLAPFVRKLPFCTCRVPDNNLPYFHKRPQARMLLLALFCVTVSVVWGIFRNEDQWAWVLQDTLGIAFCLYMLKTIRLPTFKACTLLLLVLFIYDIFFVFITPFLTKSGNSIMVEVATGPSNSSTHEKLPMVLKVPRLNTSPLSLCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRIYFVACTIAYGLGLLVTFVALVLMQRGQPALLYLVPCTLLTSCTVALWRRELGAFWTGSGFAKDAPQTPWAATQGPVPPKAVGSSLSEQPPSEELAKSPLSTEEAGAADPAKDPDNPVASPLSPSNGDEAQPIPVVKPETSA

Gene
Sppl2b
Protein
Signal peptide peptidase-like 2B
Organism
Rattus norvegicus
Length
577 amino acids
Function
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity.
Similarity
Belongs to the peptidase A22B family.
Mass
63.737 kDa
Sequence
MAAARLAASLLLLAAQVACEFGVLRVVPQSGGTRGRDYCILYNPQWAHLPHDLNKVSLLKLRDLSTTQLCSHLDVPVEDFTNQIALVARGNCTFYEKVRLAQGSGAHGLLIVSKERLVPPRGNKTQYEEISIPVALLSHRDLQDIFRRFGHEVMVALYAPSEPVMDYNMVIIFIMAVGTVALGGYWAGSHDVKKYMKHKRDDVPEKQEDEAVDVTPVMICVFVVMCCFMLVLLYYFYDRLVYVIIGIFCLASSTGLYSCLAPCVRKLPFCTCRVPDNNLPYFHKRPQARMLLLALFCVTVSVVWGVFRNEDQWAWVLQDTLGIAFCLYMLRTIRLPTFKACTLLLLVLFVYDIFFVFITPYLTKSGNSIMVEVATGPSNSSTHEKLPMVLKVPRLNTSPLSLCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRIYFVACTIAYGLGLLVTFVALVLMRHGQPALLYLVPCTLLTSCTVALWRREMGAFWTGSGFADAPQTPWAAPQGPVPPKDVDASLSEQPRGEELAQSPLATEEAGATDPAKDPDSPVAGPLSPSNGDQVQPIPVVTPGTSA