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SPOPL

Gene
SPOPL
Protein
Speckle-type POZ protein-like
Organism
Homo sapiens
Length
392 amino acids
Function
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.
Similarity
Belongs to the Tdpoz family.
Mass
44.647 kDa
Sequence
MSREPTPPLPGDMSTGPIAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSGPSDKMKWCLRVNPKGLDDESKDYLSLYLLLVSCPKSEVRAKFKFSLLNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGHTNTNTLKVPECRLAEDLGNLWENTRFTDCSFFVRGQEFKAHKSVLAARSPVFNAMFEHEMEESKKNRVEINDLDPEVFKEMMRFIYTGRAPNLDKMADNLLAAADKYALERLKVMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNSNQATDIMETSGWKSMIQSHPHLVAEAFRALASAQCPQFGIPRKRLKQS

Gene
Spopl
Protein
Speckle-type POZ protein-like
Organism
Mus musculus
Length
392 amino acids
Function
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP (By similarity).
Similarity
Belongs to the Tdpoz family.
Mass
44.699 kDa
Sequence
MSREPTPPLPGDMSTSPVAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSGPNDKMKWCLRVNPKGLDDESKDYLSLYLLLVSCPKSEVRAKFKFSLLNDKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNVSGHTSTNTLKVPECRLAEDLGNLWENTRFTDCCFFVRGKEFKAHKSVLAARSPVFNAMFEHEMEECTKNRVEINDLDPEVFKEMMRFVYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNNNQATDIMETSGWKSMIQSHPHLVAEAFRALASSQCPQFGIPRKRLKQS

Gene
spopl
Protein
Speckle-type POZ protein-like
Organism
Xenopus laevis
Length
392 amino acids
Function
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency.
Similarity
Belongs to the Tdpoz family.
Mass
44.643 kDa
Sequence
MHEVATTVSSAEMSSPPVAESWCYTQVKVVKFSYMWTINNFSFCREETGEVLKSSSFSSGPNDKLKWCLRVNPKGLDDESKDYLSLYLLLVSCPKNEVRAKFKFSLLNSKNEETKAMESQRAYRFVQGKDWGFKKYIRRDFLLDEANGLLPDDKLTLYCEVSVVQDSINISGQSSSNNLKVPECRLAEDMGYLWENRRFTDCSLFVEGKEFKAHKSILAARSPVFSAMFEHPMQESRKNRVYIRDVDPEVFKEMMRFIYTGGTPHVDKMADKLLAAADKYALERLKVMCEESLCNNLTVENVADVLILADLHSAEQLKAQAIDFINRCSVLGQLGCKDRKNCNSNQTMDIMETAGWKSMIKSHPHLVAEAFRALASAQCPPFGIPRKRLKQS