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SPO11

Gene
SPO11
Protein
Meiosis-specific protein SPO11
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
398 amino acids
Function
Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The action of SPO11 is important in setting off a regulatory chain of events encompassing 5' to 3' resection. When there are no SPO11-DSBs, resection of a site specific VDE-DSB takes place but it is faster than in wild-type meiosis and increases the risk of uncovering flanking homology.
Similarity
Belongs to the TOP6A family.
Mass
45.413 kDa
Sequence
MALEGLRKKYKTRQELVKALTPKRRSIHLNSNGHSNGTPCSNADVLAHIKHFLSLAANSLEQHQQPISIVFQNKKKKGDTSSPDIHTTLDFPLNGPHLCTHQFKLKRCAILLNLLKVVMEKLPLGKNTTVRDIFYSNVELFQRQANVVQWLDVIRFNFKLSPRKSLNIIPAQKGLVYSPFPIDIYDNILTCENEPKMQKQTIFPGKPCLIPFFQDDAVIKLGTTSMCNIVIVEKEAVFTKLVNNYHKLSTNTMLITGKGFPDFLTRLFLKKLEQYCSKLISDCSIFTDADPYGISIALNYTHSNERNAYICTMANYKGIRITQVLAQNNEVHNKSIQLLSLNQRDYSLAKNLIASLTANSWDIATSPLKNVIIECQREIFFQKKAEMNEIDARIFEYK

Gene
SPO11
Protein
Meiotic recombination protein SPO11
Organism
Homo sapiens
Length
396 amino acids
Function
Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.
Similarity
Belongs to the TOP6A family.
Mass
44.537 kDa
Sequence
MAFAPMGPEASFFDVLDRHRESLLAALRRGGREPPTGGSRLASSSEVLASIENIIQDIITSLARNEAPAFTIDNRSSWENIKFEDSVGLQMVSHCTTRKIKSDSPKSAQKFSLILKILSMIYKLVQSNTYATKRDIYYTDSQLFGNQTVVDNIINDISCMLKVSRRSLHILSTSKGLIAGNLRYIEEDGTKVNCTCGATAVAVPSNIQGIRNLVTDAKFVLIVEKDATFQRLLDDNFCNKLSPCIMITGKGVPDLNTRLLVKKLWDTFHVPVFTLVDADPHGIEIMCIYKYGSMSMSFEAHHLTVPAIRWLGLLPSDLKRLNVPKDSLIPLTKRDQMKLDSILRRPYVTCQPFWRKEMEIMADSKMKAEIQALTFLSSDYLSRVYLPNKLKFGGWI

Gene
Spo11
Protein
Meiotic recombination protein SPO11
Organism
Mus musculus
Length
396 amino acids
Function
Isoform 4: In contrast to isoform 1, does not mediate DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.
Similarity
Belongs to the TOP6A family.
Mass
44.57 kDa
Sequence
MAFAPMGPEASFFDALDRHRASLLAMVKRGAGETPAGATRVASSSEVLTAIENIIQDIIKSLARNEVPAFTIDNRSSWENIMFDDSVGLRMIPQCTTRKIRSDSPKSVKKFALILKVLSMIYKLIQSDTYATKRDIYYTDSQLFGNQAAVDSAIDDISCMLKVPRRSLHVLSTSKGLIAGNLRYMEEDGTRVQCTCSATATAVPTNIQGMQHLITDAKFLLIVEKDATFQRLLDDNFCSRMSPCIMVTGKGVPDLNTRLLVKKLWDTFHIPVFTLVDADPYGIEIMCIYKYGSMSMSFEAHNLTIPTIRWLGLLPSDIQRLNIPKDSLIPLTKHDQMKLDSILKRPYITYQPLWKKELEMMADSKMKAEIQALTLLSSDYLSRVYLPNKLRFGGWI

Gene
SPO11
Protein
Probable meiosis-specific protein SPO11 homolog
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
303 amino acids
Function
Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity).
Similarity
Belongs to the TOP6A family.
Mass
34.749 kDa
Sequence
MALAPTSSAISGSLRSSMLKLLMRLKSRTLATRLRLYEIIIEMQELGITRNEREIFYMDVNVFRTQSVVRRLVSSIASELQISKHDLGVRNTLKGIFIGRLGFVRHHGLGMVEMSSKGGCPQLIPDMSDIAEVLCDYKKTVVVEKDTVLQRIASEIEREKCLEEILFVCGKGYPCKNTVLLLKMIEHKTAVAGLFDLDPFGIHIFCIYKYGSKETPDIRVETIMRIGVCMEDVLEKNAYKDVFVKLNVHDLKMINRLVRFGELSADLLFLRKIDGKVEMEALFSKEPRRLRYFLFRMLERISS

Gene
SPO11
Protein
Probable meiosis-specific protein SPO11 homolog
Organism
Nosema ceranae (strain BRL01)
Length
271 amino acids
Function
Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity).
Similarity
Belongs to the TOP6A family.
Mass
32.095 kDa
Sequence
MKNNLKVKLEELVIYILKNIKRYPNIIQRLKFYEQIHLGLTLNKIKNKREIYYNSVSIFKKQSIVDMLIKDTCNKLKCTQSDLLISTTLKGVFYGNITFYKNNKLVHVNLKGTSLIPDMNQIDRIEYTQKKCLIIEKDTIFSKTVREYISNDILFICGKGYPCRNTLLLVNKLNIRKYGIFDFDPYGLEICTKYPSIKKIGIDIKDINLIDKQHFMILNKYDIRKINTLLKQKVYEIELFYMLKNNIKIEIEGLFSAKGFDINNYFYTKII