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SPDYA

Gene
SPDYA
Protein
Speedy protein A
Organism
Homo sapiens
Length
313 amino acids
Function
Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995). Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962).
Similarity
Belongs to the Speedy/Ringo family.
Mass
36.463 kDa
Sequence
MRHNQMCCETPPTVTVYVKSGSNRSHQPKKPITLKRPICKDNWQAFEKNTHNNNKSKRPKGPCLVIQRQDMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEETKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVQLPRGPSATPVDCSLCGKKRRYVRLGLSSSSSLSSHTAGVTEKHSQDSYNSLSMDIIGDPSQAYTGSEVVNDHQSNKGKKTNFLKKDKSMEWFTGSEE

Gene
Spdya
Protein
Speedy protein A
Organism
Rattus norvegicus
Length
312 amino acids
Function
Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Interferes with CDKN1B-mediated inhibition of CDK2. Mediates cell survival during the DNA damage process through activation of CDK2.
Similarity
Belongs to the Speedy/Ringo family.
Mass
36.223 kDa
Sequence
MRHNQMCCETPPTVTVHVKSGSNRSHQTRKPVSLKRPILKDSWQASEKNAHNNKPKRPRGPCLIIQRQEMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEEAKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPSHYIWQRERSVHHSGAARNYNRDEVHLPRGPSATPVDCSLCGKKGRYVRLGLSSSSSSSSDIVELTGKRSQELHNSLSMDMIGDPSQANTYSQVANDHQSKKENETNFVKKTKSMGWFAESEE

Gene
Spdya
Protein
Speedy protein A
Organism
Mus musculus
Length
310 amino acids
Function
Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:15611625). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation. Interferes with CDKN1B-mediated inhibition of CDK2. Mediates cell survival during the DNA damage process through activation of CDK2 (By similarity).
Similarity
Belongs to the Speedy/Ringo family.
Mass
36.115 kDa
Sequence
MRHNQMYCETPPTVTIHVKSGSNRSHQTRKPISLKRPILKDSWEASENNAQNNKSKRPRGPCLIIQRQEMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTINEHTRINFFIALYLANTVEEDEEEAKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVHLPRGPSATPVDCSLCGKKGRYVRLGLSSSSSSSSDTGELMEKDSQELHSAFSVDTAGDPPHTYSQVANDHQSNKENETNFVKKNKSVEWFAESEE