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SPDL1

Gene
spdl1
Protein
Protein Spindly
Organism
Xenopus tropicalis
Length
611 amino acids
Function
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. May act as an adapter protein linking the dynein motor complex to various cargos (By similarity).
Similarity
Belongs to the Spindly family.
Mass
70.708 kDa
Sequence
MEESETVLKLRLQLKEAEEERIKAAQYGLELLESQSDLQNQLEEQRNEMTSTIENLEQEKYSLQREVELKNRMLESLTSECENIRQQQKLCLEQLQEQLERNHHRELSEIKDKLEKLKAELDEARLSEKQLKHKLEYQSEVLANKSEELRMMSERVHETMSSEMLTLQLEKTELESAKANLEQEVNELQYREQQLLLTNGTQSRQLERLQDEKEDREKEAVGYFKALEKAREANQDLQAQLDIALQQAQDPNSKGNSLFAEVEDRRAEMERQLISMKVQFQSLQKQHAFSRQQMHRMKVQIATLLQLKGSQSDPEQLERLQAMVAQKNSEFETLVMKVRQLEKSQQICENGPVANSSDGLGQGDETYYVDLLKMKLVNSSKEIEKIKDELSLQRMKALAESQRVLDLERKLFANDRHLKLSQGENMKLRVNLDEMKMKYEPDEIAKIRTQKRRKEQLPLDCAIDNTSATVTSGSQAHGLSDAIPEDMCPAESTVHRNLLKEDSSLSTKEQDLSSVAVKPIEPANGQPPKERKRVRIVENENDNQDINKRNTNNCSVTSTSPRSASEESTSESKRFDEEQEKRKQERKSRLRAPPVLHVPSKPAATTQCPQQ

Gene
Spdl1
Protein
Protein Spindly
Organism
Mus musculus
Length
608 amino acids
Function
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity).
Similarity
Belongs to the Spindly family.
Mass
70.237 kDa
Sequence
MEADITNLRNKLKECEDERLKAAHYGLQLLERQTELQSQLDKCHEEMMITAEKYNQEKHALQREVELKSRMLDSLSCECEALKQQQKAQLEQLEVQLHRSHRQEVSDLKNKLENLKVELDEARLGEKQLKQKLDLQGELLAHKSEELRLLSEQRVLSSMSSELLALETELTAAEGVKNALKEEVNELQYKQEQLECLNTSLLHQVDRLKEEKEEREREAVSYYNALEKARVENQDLQVQLGHALQQAADPNSKGNSLFAEVEDRRVAMERQLNLMKDKYQSLKKQNAFTRDQMNKMKLQISTLLRMRGSQTEFEQQERLFAMIEQKNGEIKHLLGEINKLEKFKNLYESMESRPSTSDTACVLEDSTYYSDLLQLKLDKLNKENESTKDELSIQRMKALFESQRALDIERKLFTNERHLQLSESENMKLRAKLDELKLKYEPEERIEVPVLKRRREVLPLNITTPEETEETAAASATEDGVSRLPPHREEESCLNSLKDNTVQWKQPASSCVQPASLSPHKNLHLDTQPKKEKKCVKLVDSPANIEVLHEQSGNTPNSPRLTAESKLPTEVKERIETTSKLGKGACKKSHNIIYVSSKSAPETQCSQQ

Gene
SPDL1
Protein
Protein Spindly
Organism
Homo sapiens
Length
605 amino acids
Function
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment (PubMed:17576797, PubMed:19468067). Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).
Similarity
Belongs to the Spindly family.
Mass
70.172 kDa
Sequence
MEADIITNLRCRLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKTKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYDSMESKPSVDSGTLEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTAKDACVNNSALGGEVYRLPPQKEETQSCPNSLEDNNLQLEKSVSIYTPVVSLSPHKNLPVDMQLKKEKKCVKLIGVPADAEALSERSGNTPNSPRLAAESKLQTEVKEGKETSSKLEKETCKKLHPILYVSSKSTPETQCPQQ

Gene
SPDL1
Protein
Protein Spindly
Organism
Macaca fascicularis
Length
605 amino acids
Function
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity).
Similarity
Belongs to the Spindly family.
Mass
70.138 kDa
Sequence
METDIVINLRCKLKEAEEERLKAAQYGLQLVESQNELQNQLDKCRNEMMTMTESYEQEKYTLQREVELKSRMLESLSCECEAIKQQQKMHLEKLEEQLSRSHGQEVNELKSKIEKLKVELDEARLSEKQLKHQVDHQKELLSCKSEELRVMSERVQESMSSEMLALQIELTEMESMKTTLKEEVNELQYRQEQLELLITNLMRQVDRLKEEKEEREKEAVSYYNALEKARVANQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNVFNREQMQRMKLQIATLLQMKGSQTEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKNLYESMESKPSVDSGALEDNTYYTDLLQMKLDNLNKEIESTKGELSIQRMKALFESQRALDIERKLFANERCLQLSESENMKLRAKLDELKLKYEPEETVEVPVLKKRREVLPVDITTSKDTCVNNSAVGGEVYRLPPQKEETQCCPNSLEDNNLQLEKSVSIHTPIVSLSPHKNLPVDMQLKKEKKCVKLVGVPADAEALSERSGNTLNSPRLAAESKLQTEVKEGKETASKLEKETCKKSHPILYVSSKSTPETQCPQQ

Gene
SPDL1
Protein
Protein Spindly
Organism
Bos taurus
Length
603 amino acids
Function
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity).
Similarity
Belongs to the Spindly family.
Mass
69.621 kDa
Sequence
MESDVIADLRCKLKETEEERRKAAQYGLQLVESQNELQNQLDKCRNEMMTLTESYEQEKYTLQREVELKSRMLESLSSECETIKQQQKMHLEQLEETLSRSHGQEVNELKKKLETLKAELDEARLSEKQLKHKVDHQEKLLSSKSKEMQMSERVHESVSSETLTLQIELTEMENVKTTLQEEVNELQYRQEQLELLNANLMRQVDRLKGEKEEREKEAVSYYDALEKARVVNQDLQVQLDQALQQALDPNSKGNSLFAEVEDRRAAMERQLISMKVKYQSLKKQNAFNREQMQRMKVQIATLLQMKGSQAEFEQQERLLAMLEQKNGEIKHLLGEIRNLEKFKSLYESMESKPSANSVALEDDTYYTDLLQIKLDNLNKESESIKGELSIQRMKALLESQRALDIERKLFLNERHLQLSQSENMKLRAKLDELKLKYEPEEKIEVPVLKKRREVLPVDISTPNGVCAPSAVGEEDYRLSPQKEEAQSCSDGSEDNNLQLEKTVSVSTSGVILSPYKSLTLDIQPRKEKKCVKLTGVPADLEALSERSRNTPNSPRLAAESRLQREVKQGKETASKLEKAACKKSYPTVYVSSKSTPETQCPQQ

Gene
Spdl1
Protein
Protein Spindly
Organism
Rattus norvegicus
Length
597 amino acids
Function
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity).
Similarity
Belongs to the Spindly family.
Mass
69.112 kDa
Sequence
MEADITNLRNKLKECEDERLKAAQYGLQLLERQTELQSQLDKCHEEMMTTAENYNQEKYALQREVELKSRMLESLSCECEALRQQQKAQLEQLEMQLHRSHRQEVHGLRNKLENLKVELDEARLSEKQLKQKLDHQGELLSHKSEELRLLSEQRALSSVSSELLSLQTELTEAEGVKNALREEVNELQCKQEQLECLNASLLHQVDRLKEEKEEREKEAVSYYNALEKARVENQDLQVQLGHALQQAADPNSKGNSLFAEVEDRRVAMERRLNLMKDKYQSLKKQNAFTRDQMNKMKLQISTLLRMRGSQTEFEQQERLFAMLEQKNGEIKHLLGEINKLEKFKNLYENMESKSSTSDSACALEDSTYYTDLLQLKLDKLNKENESTKGELSIQRMKALFESQRTLDIERKLFANERHLQLSESENLKLRAKLDELKLKYEPEERIEVPVLKRRREVLPLNINTPEETAAASATGEDVSRLPLERKEESCLDNLKDNTVQWKQPASLSPHKSLPLDTQPKKEKCVTLVASPASTEVLHEQSGNTPSSPRLTEESRLPTKVKERKEATSKLEKGASKKSHTIMYVSSKSTPEMQCPQQ

Gene
spdl1
Protein
Protein Spindly
Organism
Danio rerio
Length
590 amino acids
Function
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. May act as an adapter protein linking the dynein motor complex to various cargos (By similarity).
Similarity
Belongs to the Spindly family.
Mass
68.964 kDa
Sequence
MSDLEDEIKVLRRKVQDGEEALQRAGQYGLQLLDEKMELHNRLEEQRTEMSNVIEALEQDKYTLQREVELKIRMLESLRSEFDLVRTQQKHQMEQQQTLLERNHAVEISDLKNKVVKMKTDLEEAQLAEKQMRHKLDQQAEALNSKTEELRALTERAHETMSSEILELQVQKMELESAMATLEQELQEAQYKDEQLHLANTTLQRQLERLTEEKEEREKEAVSCYNALEKAREANQDLQIQLEQVLQQAQDPNSKGNSLFSEVEDKRAAMERQLNSMKRNYDSLQKQHVLTKQHMHHMKMQIATLMQLQGNRADPAQLERLQFMLSDKNKEIESLMMKVRELEKEKMAVKDHHPHPPSNEGELKDETYYTDLLKMQLANSKKDAEKLKEELSMARMKALSESQRVLELERKLYGTEQALKLRHSDNMKLQVKLEELKIKYTPNEVNKAQVQKRRREKFPVPEENSASVKDETTTQDTELSKNSNEKAEEKTPSHPVEKPVVIPLQSEHPTEPNPVLSRESKSVRICEDPPVCIPDAPRSPVNDSNSKNVDQTHQSSEEEENWRTEKKRKKYQQPTHVSSQKTMANECAQQ