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SNX3

Gene
SNX3
Protein
Sorting nexin-3
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
394 amino acids
Function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
42.068 kDa
Sequence
MAFYSAGPLSPGYNSTSAWGGNDNAEEDPWAAPGSSSSAAPPTTSSGFAPSPPGGFASFSTQQQQQQQQQQQRQQAGYFGGAPAAGASLAQEADAYQDGLMETSFGVGSGAGQNRLGGAAATVNPQSPHNAHSSSSTYGSAISSTHSQPSTQSQQPQSHALPSSAAQAQAARAGAFPSGVSTSQYQPTSQGAQGASRFQSHTPSTLLPSEPAGFTSHTSSDYSATAPRQLAPGYPLPASNYTVPAYSPFARVDSLSTPRRETVEDMYGVPENFLEVEVRSPLTHGVGRKMYTDYEIVTRTNIPAFKLRYSSVRRRYSDFEYFRDILERESTRVNIPPLPGKVFTNRFTDEVIEARREGLERFLQVVAGHPLLQTGSKVMAAFLQDSGWSKDQWL

Gene
SNX3
Protein
Sorting nexin-3
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
164 amino acids
Function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
18.713 kDa
Sequence
MCPQRQFQSFTTTAESTLSHTTHKQLSGATIYDEPENFLEIEVCNPKTHFPSGDAKGMYTDYEIICRTNLPGFSKRSSSVRRRYSDFELFRKLLIKELQLSNHPKVSVQHLPGKILLSNRFSDAVIEERRQGLNKWLASVAGHPLLQTGSKVLVRFIQDPTFQG

Gene
SNX3
Protein
Sorting nexin-3
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
164 amino acids
Function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
19.339 kDa
Sequence
MSGKREFKSFGSTEETMFSQHHKIPSTSEMYAEPENFLEIEVRNPKTHVPNGVDQRGMYTDYEIICRTNLPNFHKRASRVRRRYSDFEFFRKCLLKEISMLNNPRVVVPHLPGKIYLSNRFSDEVIEERRQGLNRWMQIVAGHPLLQSGSKTLIRFIEDDKFVG

Gene
SNX3
Protein
Sorting nexin-3
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
163 amino acids
Function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
18.885 kDa
Sequence
MASDQDNSGLDAPGSQFHRPILQSMPDTRQQSFDEIYGPPENFLEIEVRNPRTHGMGRHMYTDYEILCRTNIPAFKLRQSSVRRRYSDFEYFRDILERESARVTIPPLPGKVFTNRFSDDVIEGRRAGLEKFLKIVVGHPLLQTGSKVLAAFVQDPNWDRNAW

Gene
SNX3
Protein
Sorting nexin-3
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
163 amino acids
Function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
18.85 kDa
Sequence
MRQFQSFSTTVERELAAAPTARPARTAAGYDEPENFLEVEVRDPRTHFPHGDSNRGMYTDYLVVCRTNLPSFPQRVSQVRRRYSDFEFFKRCLFKELSLSAHPRVVIPALPGKILWARRFHDEVIEERREGLAQWLSTVAGHPLLQSGSKVLVRFLQDEVFNG

Gene
SNX3
Protein
Sorting nexin-3
Organism
Homo sapiens
Length
162 amino acids
Function
Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551).
Similarity
Belongs to the sorting nexin family.
Mass
18.762 kDa
Sequence
MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

Gene
Snx3
Protein
Sorting nexin-3
Organism
Mus musculus
Length
162 amino acids
Function
Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (PubMed:19576982). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (By similarity). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (PubMed:18632802). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (By similarity). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (PubMed:23416069). Involved in regulation of neurite outgrowth in primary neurons (PubMed:19576982).
Similarity
Belongs to the sorting nexin family.
Mass
18.757 kDa
Sequence
MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRHVPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

Gene
SNX3
Protein
Sorting nexin-3
Organism
Pongo abelii
Length
162 amino acids
Function
Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. Involved in regulation of neurite outgrowth in primary neurons.
Similarity
Belongs to the sorting nexin family.
Mass
18.762 kDa
Sequence
MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

Gene
Snx3
Protein
Sorting nexin-3
Organism
Rattus norvegicus
Length
162 amino acids
Function
Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. Involved in regulation of neurite outgrowth in primary neurons.
Similarity
Belongs to the sorting nexin family.
Mass
18.762 kDa
Sequence
MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

Gene
SNX3
Protein
Sorting nexin-3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
162 amino acids
Function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).
Similarity
Belongs to the sorting nexin family.
Mass
18.77 kDa
Sequence
MPREFKSFGSTEKSLLSKGHGEPSYSEIYAEPENFLEIEVHNPKTHIPNGMDSKGMFTDYEIICRTNLPSFHKRVSKVRRRYSDFEFFRKCLIKEISMLNHPKVMVPHLPGKILLSNRFSNEVIEERRQGLNTWMQSVAGHPLLQSGSKVLVRFIEAEKFVG

Gene
SNX3
Protein
Sorting nexin-3
Organism
Bos taurus
Length
162 amino acids
Function
Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. Involved in regulation of neurite outgrowth in primary neurons.
Similarity
Belongs to the sorting nexin family.
Mass
18.762 kDa
Sequence
MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

Gene
SNX3
Protein
Sorting nexin-3
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
157 amino acids
Function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
18.362 kDa
Sequence
MSKPFQPISDVINTSPKNKSQSFNEIYGEPENFLEIEVKNPLTHGYGSNLFTDYEIVCRTNIPAFKKRESRIRRRYSDFVAFRKILEQETTRVIIPPLPGKIFLNSNKFNDLNIEKRRQGLEKFLIVVSGHPLLQTGSKSLIEFIQNEKWDPKQIIY

Gene
SNX3
Protein
Sorting nexin-3
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
152 amino acids
Function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
17.706 kDa
Sequence
MEASPKKPEALQRPDIKQQSFAEIYGVPENFLEIEVRSPQTHGIARKMYTDYEIVCRTNIPVFKLKSSVVRRRYSDFECFREILERESTRVSIPSLPGKVFTNRFSDEVIEARREGLEKFLQTVAGHPLLQTGSKVLCAFIQDPQWDKNQWI

Gene
SNX3
Protein
Sorting nexin-3
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
144 amino acids
Function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
16.894 kDa
Sequence
MARMAGRPQTFDEMYSVPESFLEIEIRNPMTHGIGRKMYTDYEIVCMTNIPAFKLRHSAVRRRYSDFEAFRDILERESTRVNIPPLPGKVRVFTNRFSDEVIEQRREGLQRFLEIVAGHPLLQTGSKVLCAFLQDPAWDKSQWI

Gene
SNX3
Protein
Sorting nexin-3
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
144 amino acids
Function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
16.894 kDa
Sequence
MARMAGRPQTFDEMYSVPESFLEIEIRNPMTHGIGRKMYTDYEIVCMTNIPAFKLRHSAVRRRYSDFEAFRDILERESTRVNIPPLPGKVRVFTNRFSDEVIEQRREGLQRFLEIVAGHPLLQTGSKVLCAFLQDPAWDKSQWI

Gene
snx3
Protein
Sorting nexin-3
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
143 amino acids
Function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
16.961 kDa
Sequence
MDKLSRPEIRQQTTQQMYDVPENILEIDVINPQTHGIGRNMFTTYEIVCRTNMPYFRLHNSSVRRRYSEFEKFHDMLERESGRVSIPPLPGKIFTQRFRDDVIEERRQGLENFLRLVAGHPLIQTHSRVLSSFLQSPEFKPTP

Gene
snx3
Protein
Sorting nexin-3
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
142 amino acids
Function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
16.755 kDa
Sequence
MQAVPESRQQTFEEIYGPPENFLEIEVRNPQTHGTSRNMYTSYEIVCRTNIPAFKLKHSVVRRRYSDFEYFRDILERESTRVTIPPLPGKVFTNRFSDDVIEHRREGLQRFLQIVAGHPLLQTGSKVLASFIQDPNWDRNAW

Gene
snx3
Protein
Sorting nexin-3
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
142 amino acids
Function
Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
Similarity
Belongs to the sorting nexin family.
Mass
16.755 kDa
Sequence
MQAVPESRQQTFEEIYGPPENFLEIEVRNPQTHGTSRNMYTSYEIVCRTNIPAFKLKHSVVRRRYSDFEYFRDILERESTRVTIPPLPGKVFTNRFSDDVIEHRREGLQRFLQIVAGHPLLQTGSKVLASFIQDPNWDRNAW